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Gastroenterology Research and Practice
Volume 2010, Article ID 750904, 6 pages
http://dx.doi.org/10.1155/2010/750904
Review Article

Toll-Like Receptor 3 in Liver Diseases

Shi Yin1,2 and Bin Gao1

1Laboratory of Liver Diseases, National Institute on Alcohol Abuse and Alcoholism, National Institutes of Health, Bethesda, 5625 Fishers Lane, MD 20892, USA
2Department of Geriatrics, The Affiliated Provincial Hospital of Anhui Medical University, Hefei, Anhui 230001, China

Received 27 April 2010; Accepted 14 July 2010

Academic Editor: Ekihiro Seki

Copyright © 2010 Shi Yin and Bin Gao. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Toll-like receptor 3 (TLR3) is a member of the TLR family that can recognize double-stranded RNA (dsRNA), playing an important role in antiviral immunity. Recent studies have shown that TLR3 is also expressed on parenchymal and nonparenchymal cells in the liver as well as on several types of immune cells. In this review, we summarize the role of TLR3 in liver injury, inflammation, regeneration, and liver fibrosis, and discuss the implication of TLR3 in the pathogenesis of human liver diseases including viral hepatitis and autoimmune liver disease.