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Gastroenterology Research and Practice
Volume 2012 (2012), Article ID 640168, 5 pages
http://dx.doi.org/10.1155/2012/640168
Clinical Study

miR-21 Is a Promising Novel Biomarker for Lymph Node Metastasis in Patients with Gastric Cancer

1Department of Oncology, The Second Hospital of Nanjing, South East University, Nanjing 210003, China
2Department of Oncology, Putuo Hospital, Shanghai University of Traditional Chinese Medicine, Shanghai 200062, China
3Department of Oncology, Shanghai Sixth People’s Hospital, Shanghai Jiao Tong University, Shanghai 200233, China

Received 26 February 2012; Accepted 30 April 2012

Academic Editor: Richard Ricachenevski Gurski

Copyright © 2012 Yuejuan Xu et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Citations to this Article [34 citations]

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  • Purificación Muñoz, Maria S. Iliou, and Manel Esteller, “Epigenetic alterations involved in cancer stem cell reprogramming,” Molecular Oncology, vol. 6, no. 6, pp. 620–636, 2012. View at Publisher · View at Google Scholar
  • Ying Yin, Jun Li, Shujie Chen, Tianhua Zhou, and Jianmin Si, “MicroRNAs as diagnostic biomarkers in gastric cancer,” International Journal of Molecular Sciences, vol. 13, no. 10, pp. 12544–12555, 2012. View at Publisher · View at Google Scholar
  • Ji-Lin Wang, Ye Hu, Xuan Kong, Zhen-Hua Wang, Hao-Yan Chen, Jie Xu, and Jing-Yuan Fang, “Candidate microRNA Biomarkers in Human Gastric Cancer: A Systematic Review and Validation Study,” Plos One, vol. 8, no. 9, 2013. View at Publisher · View at Google Scholar
  • Zishu Wang, Jin Wang, Yan Yang, Bo Hao, Rui Wang, Yumei Li, and Qiong Wu, “Loss of has-miR-337-3p expression is associated with lymph node metastasis of human gastric cancer,” Journal of Experimental & Clinical Cancer Research, vol. 32, 2013. View at Publisher · View at Google Scholar
  • Yong Huang, Xiang Chao Cheng, You Bing Yang, Xiao Hui Zhang, Xue Li Yu, and Zhan Bin Wang, “MicroRNA-21 gene and cancer,” Medical Oncology, vol. 30, no. 1, 2013. View at Publisher · View at Google Scholar
  • Chang In Choi, Dong Heon Kim, Gwang Ha Kim, Dong Yup Ryu, Shine Young Kim, Dae Hwan Kim, Hyung Hoi Kim, Tae Yong Jeon, and Bong Eun Lee, “Validation of Circulating miRNA Biomarkers for Predicting Lymph Node Metastasis in Gastric Cancer,” Journal Of Molecular Diagnostics, vol. 15, no. 5, pp. 661–669, 2013. View at Publisher · View at Google Scholar
  • Xingwen Li, Xiaoning Zhao, and Huqin Yuan, “microRNAs in gastric cancer invasion and metastasis,” Frontiers In Bioscience-Landmark, vol. 18, pp. 803–810, 2013. View at Publisher · View at Google Scholar
  • Xiaohui Xu, Xiaodong Yang, Jianping Cao, and Shuyu Zhang, “miRNA: The nemesis of gastric cancer,” Oncology Letters, vol. 6, no. 3, pp. 631–641, 2013. View at Publisher · View at Google Scholar
  • Han-Shao Liu, and Hua-Sheng Xiao, “MicroRNAs as potential biomarkers for gastric cancer,” World Journal of Gastroenterology, vol. 20, no. 34, pp. 12007–12017, 2014. View at Publisher · View at Google Scholar
  • Tianhe Zeng, and Guiling Li, “MicroRNA-10a enhances the metastatic potential of cervical cancer cells by targeting phosphatase and tensin homologue,” Molecular Medicine Reports, vol. 10, no. 3, pp. 1377–1382, 2014. View at Publisher · View at Google Scholar
  • Xin Zhou, Xiaping Wang, Zebo Huang, Jian Wang, Wei Zhu, Yongqian Shu, and Ping Liu, “Prognostic Value of miR-21 in Various Cancers: An Updating Meta-Analysis,” Plos One, vol. 9, no. 7, 2014. View at Publisher · View at Google Scholar
  • Juliette M. C. Bouyssou, Salomon Manier, D Daisy Huynh, Samar Issa, and Aldo M. Roccaro, “Regulation of microRNAs in cancer metastasis,” Biochimica et Biophysica Acta-Reviews on Cancer, vol. 1845, no. 2, pp. 255–265, 2014. View at Publisher · View at Google Scholar
  • Jn Song Jianning, Zg Bai Zhigang, and Zt Zhang Zhongtao, “MicroRNAs are implicated in the initiation and progression of gastric cancer,” Chinese Medical Journal, vol. 127, no. 3, pp. 554–559, 2014. View at Publisher · View at Google Scholar
  • Hua-Hsi Wu, Wen-chang Lin, and Kuo-Wang Tsai, “Advances in molecular biomarkers for gastric cancer: miRNAs as emerging novel cancer markers,” Expert Reviews in Molecular Medicine, vol. 16, 2014. View at Publisher · View at Google Scholar
  • Chen Li, “Prognostic Role of MicroRNA-21 in Gastric Cancer: a Meta-Analysis,” Medical Science Monitor, vol. 20, pp. 1668–1674, 2014. View at Publisher · View at Google Scholar
  • Salomon Manier, Juliette M.C. Bouyssou, Daisy Huynh, Aldo M. Roccaro, Irene M. Ghobrial, and Samar Issa, “Regulation of microRNAs in cancer metastasis,” Biochimica et Biophysica Acta - Reviews on Cancer, vol. 1845, no. 2, pp. 255–265, 2014. View at Publisher · View at Google Scholar
  • Zhaoqi Shi, Qingxia Wei, and Junjun She, “MicroRNAs in gastric cancer metastasis,” Critical Reviews in Eukaryotic Gene Expression, vol. 24, no. 1, pp. 39–53, 2014. View at Publisher · View at Google Scholar
  • Inés Omrane, Nadia Kourda, Nejla Stambouli, Maud Privat, Imen Medimegh, Amira Arfaoui, Nancy Uhrhammer, Karim Bougatef, Olfa Baroudi, Hassen Bouzaienne, Raja Marrakchi, Yves-Jean Bignon, and Amel Benammar-Elgaaied, “MicroRNAs 146a and 147b Biomarkers for Colorectal Tumor’s Localization,” BioMed Research International, vol. 2014, pp. 1–9, 2014. View at Publisher · View at Google Scholar
  • Xiaoyun Ding, Xiangxiang Wan, Haizhong Jiang, Haojun Song, Ying Fang, Shengcan Chen, Peifei Li, and Junming Guo, “The clinical value of ncRNAs in gastric cancer: a systematic review and meta-analyses,” Tumor Biology, vol. 36, no. 6, pp. 4017–4025, 2015. View at Publisher · View at Google Scholar
  • C Jiang, X Chen, M Alattar, J Wei, and H Liu, “MicroRNAs in tumorigenesis, metastasis, diagnosis and prognosis of gastric cancer,” Cancer Gene Therapy, 2015. View at Publisher · View at Google Scholar
  • Inés Omrane, and Amel Benammar-Elgaaied, “Immune microenvironment of colorectal tumor: Involvement of immunity genes and microRNA belonging to TH17 pathway,” Biochimica et Biophysica Acta (BBA) - Reviews on Cancer, 2015. View at Publisher · View at Google Scholar
  • Jia Li, Yin Jin, Shuang Pan, Yina Chen, Kaijing Wang, Chunjing Lin, Shuqing Jin, and Jiansheng Wu, “TCEA3 attenuates gastric cancer growth by apoptosis induction,” Medical Science Monitor, vol. 21, pp. 3241–3246, 2015. View at Publisher · View at Google Scholar
  • Qing Yang, Ren-Wen Zhang, Peng-Cheng Sui, Hai-Tao He, and Lei Ding, “Dysregulation of non-coding RNAs in gastric cancer,” World Journal Of Gastroenterology, vol. 21, no. 39, pp. 10956–10981, 2015. View at Publisher · View at Google Scholar
  • Hosein Effatpanah, Reza Yadegarazari, Manoochehr Karami, Amir Majlesi, Nooshin Shabab, and Massoud Saidijam, “Expression analysis of miR-21 and miR-221 in cancerous tissues from Iranian patients with gastric cancer,” Iranian Biomedical Journal, vol. 19, no. 4, pp. 188–193, 2015. View at Publisher · View at Google Scholar
  • Sylvain Darnet, Samia Demachki, Monica Assumpção, Paulo Assumpção, Ândrea Ribeiro-Dos-Santos, Fabiano C. Moreira, Igor G.. Hamoy, Rommel Burbano, André Khayat, Aline Cruz, Leandro Magalhães, Artur Silva, and Sidney Santos, “High-throughput sequencing of miRNAs reveals a tissue signature in gastric cancer and suggests novel potential biomarkers,” Bioinformatics and Biology Insights, vol. 9, pp. 1–8, 2015. View at Publisher · View at Google Scholar
  • Xiaoling Wu, Xiaohui Tan, and Sidney W. Fu, “May Circulating microRNAs be Gastric Cancer Diagnostic Biomarkers?,” Journal Of Cancer, vol. 6, no. 12, pp. 1206–1213, 2015. View at Publisher · View at Google Scholar
  • Paulo Pimentel De Assumpção, Rommel Mário Rodriguez Burbano, Marília Cardoso Smith, Camila Inagaki Albuquerque, Carolina Oliveira Gigek, André Salim Khayat, Kelly Cristina Da Silva Oliveira, Danielle Queiroz Calcagno, Taíssa Maíra Thomaz Araújo, Gabriela Alcantara Barata, Mariana Ferreira Leal, Fernanda Wisnieski, and Fernando Augusto Rodrigues Mello, “Role of miRNAs and their potential to be useful as diagnostic and prognostic biomarkers in gastric cancer,” World Journal of Gastroenterology, vol. 22, no. 35, pp. 7951–7962, 2016. View at Publisher · View at Google Scholar
  • Xu-Hua Mao, Min Chen, Yan Wang, Pan-Gen Cui, Si-Bian Liu, and Zei-Yong Xu, “MicroRNA-21 regulates the ERK/NF-κB signaling pathway to affect the proliferation, migration, and apoptosis of human melanoma A375 cells by targeting SPRY1, PDCD4, and PTEN,” Molecular Carcinogenesis, 2016. View at Publisher · View at Google Scholar
  • Ming-Ming Tsai, Chia-Siu Wang, Chung-Ying Tsai, Hsiang-Wei Huang, Hsiang-Cheng Chi, Yang-Hsiang Lin, Pei-Hsuan Lu, and Kwang-Huei Lin, “Potential Diagnostic, Prognostic and Therapeutic Targets of MicroRNAs in Human Gastric Cancer,” International Journal of Molecular Sciences, vol. 17, no. 6, pp. 945, 2016. View at Publisher · View at Google Scholar
  • Durairaj Sekar, Ramalingam Krishnan, Krishnaraj Thirugnanasambantham, Baskaran Rajasekaran, Villianur Ibrahim Hairul Islam, and Punitha Sekar, “Significance of microRNA 21 in gastric cancer,” Clinics and Research in Hepatology and Gastroenterology, 2016. View at Publisher · View at Google Scholar
  • Geng-yuan Hu, Feng Tao, Wei Wang, and Ke-wei Ji, “Prognostic value of microRNA-21 in pancreatic ductal adenocarcinoma: a meta-analysis,” World Journal Of Surgical Oncology, vol. 14, 2016. View at Publisher · View at Google Scholar
  • Amanda L Treece, Daniel L Duncan, Weihua Tang, Sandra Elmore, Douglas R Morgan, Ricardo L Dominguez, Olga Speck, Michael O Meyers, and Margaret L Gulley, “Gastric adenocarcinoma microRNA profiles in fixed tissue and in plasma reveal cancer-associated and Epstein-Barr virus-related expression patterns,” Laboratory Investigation, 2016. View at Publisher · View at Google Scholar
  • Wenying Yan, Laijun Qian, Jiajia Chen, Weichang Chen, and Bairong Shen, “Comparison of Prognostic MicroRNA Biomarkers in Blood and Tissues for Gastric Cancer,” Journal Of Cancer, vol. 7, no. 1, pp. 95–106, 2016. View at Publisher · View at Google Scholar
  • Kelly Cristina Da Silva Oliveira, Danielle Queiroz Calcagno, Amanda Braga Bona, Fernanda Jardim Da Silva, Thayanne Macedo Pinheiro, Diego Di Felipe Avila Alcantara, Leticia Martins Lamarao, Caroline Aquino Moreira-Nunes, Paulo Pimentel Assumpcao, and Rommel Rodriguez Burbano, “Expression of hsa-miR-9 and MYC copy number variation in hereditary diffuse gastric cancer,” Anticancer Research, vol. 37, no. 5, pp. 2401–2406, 2017. View at Publisher · View at Google Scholar