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Gastroenterology Research and Practice
Volume 2013, Article ID 175729, 5 pages
http://dx.doi.org/10.1155/2013/175729
Clinical Study

Eradication of Helicobacter pylori Is Associated with the Progression of Dementia: A Population-Based Study

1Department of Neurology, Kaohsiung Medical University Hospital, Kaohsiung 807, Taiwan
2Department of Information, Kaohsiung Municipal Ta-Tung Hospital, Kaohsiung 801, Taiwan
3School of Medicine, College of Medicine, I-Shou University and E-Da Hospital, Kaohsiung 824, Taiwan
4Graduate Institute of Public Health, Kaohsiung Medical University, Kaohsiung 807, Taiwan
5Division of Gastroenterology, Department of Internal Medicine, Kaohsiung Medical University Hospital, Kaohsiung 807, Taiwan
6Department of Medicine, Faculty of Medicine, College of Medicine, Kaohsiung Medical University, Kaohsiung 807, Taiwan
7Administration Center, Kaohsiung Medical University Hospital, Kaohsiung 807, Taiwan
8Department of Radiology, Faculty of Medicine, College of Medicine, Kaohsiung Medical University, Kaohsiung 807, Taiwan
9Cancer Center, Kaohsiung Medical University Hospital, Kaohsiung 807, Taiwan
10Department of Internal Medicine, Kaohsiung Municipal Hsiao-Kang Hospital, Kaohsiung 812, Taiwan

Received 1 August 2013; Accepted 10 October 2013

Academic Editor: Chao-Hung Kuo

Copyright © 2013 Yang-Pei Chang et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Objective. To evaluate the effect of eradication of Helicobacter pylori (H. pylori) on the progression of dementia in Alzheimer’s disease (AD) patients with peptic ulcer. Methods. Participants with the diagnosis of AD and peptic ulcer were recruited between 2001 and 2008. We examined the association between eradication of H. pylori and the progression of AD using the multiple regression models. Medication shift from Donepezil, Rivastgmine, and Galantamine to Mematine is defined as progression of dementia according to the insurance of National Health Insurance (NHI) under expert review. Results. Among the 30142 AD patients with peptic ulcers, the ratio of medication shift in AD patients with peptic ulcers is 79.95%. There were significant lower incidence comorbidities (diabetes mellitus, hypertension, cerebrovascular disease, coronary artery disease, congestive heart failure and hyperlipidemia) in patients with H. pylori eradication as compared with no H. pylori eradication. Eradication of H. pylori was associated with a decreased risk of AD progression (odds ratio [OR] 0.35 [0.23–0.52]) as compared with no H. pylori eradication, which was not modified by comorbidities. Conclusions. Eradication of H. pylori was associated with a decreased progression of dementia as compared to no eradication of H. pylori in AD patients with peptic ulcers.