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Gastroenterology Research and Practice
Volume 2013, Article ID 785892, 10 pages
http://dx.doi.org/10.1155/2013/785892
Research Article

Helicobacter pylori Infection in Dialysis Patients: A Meta-Analysis

1Department of Gastroenterology, First Affiliated Hospital of Nanjing Medical University, Nanjing 210029, China
2First Clinical Medical College of Nanjing Medical University, Nanjing 210029, China

Received 10 July 2013; Revised 5 September 2013; Accepted 19 September 2013

Academic Editor: Khean Lee Goh

Copyright © 2013 Min Gu et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Background. Infection with Helicobacter pylori contributes to the etiopathogenesis of various extragastrointestinal conditions, yet its etiological association with either symptomatic or asymptomatic dialysis patients remains inconclusive. Methods. Two researchers working independently conducted a literature search of the online databases PubMed, EMBase, ScienceDirect, and Cochrane Central Register of Controlled Trials to identify relevant articles to the end of 2012. Case-control and cross-sectional studies that met the inclusion criteria were included. Results. Fifteen studies involving 1237 dialysis patients and 1568 controls with normal renal function were included. Compared with normal controls, dialysis patients overall were associated with a relatively lower risk of H. pylori infection though not statistically significant. A significant inverse association was found between H. pylori prevalence and duration of treatments in those who were dialyzed >4 years (odds ratio 0.28; 95% confidence interval 0.22–0.36, ). No relationship between H. pylori status and duration of dialysis was observed in CRF patients. There were no significant differences in endoscopic features between patients and controls. Conclusions. Our meta-analysis found no evidence of a significant association between infection with H. pylori and dialysis overall, whereas long-term treatments of more than four years had a significant protective effect.