S100A8 and S100A9 Positive Cells in Colorectal Carcinoma: Clinicopathological Analysis

Table 2

Distribution of clinicopathologic parameters according to median values S100A8/A9 positive cells in both intratumoral and peritumoral areas. (Chi-square test, .)

Parameters	S100 A8 (intratumoral)			S100 A8 (peritumoral)			S100 A9 (intratumoral)			S100 A9 (peritumoral)
	<123 (%)	>123 (%)		<198 (%)	>198 (%)		<147 (%)	>147 (%)		<297 (%)	>297 (%)
Age (years)
<64	19 (55.9)	15 (44.1)	0.16	20 (58.8)	14 (41.2)	0.12	19 (55.9)	15 (44.1)	0.27	20 (58.8)	14 (41.2)	0.12
>64	20 (43.5)	26 (56.5)		19 (41.3)	27 (58.7)		20 (43.5)	20 (43.5)		19 (41.3)	27 (58.7)
Gender
Female	17 (41.5)	24 (58.5)	0.54	15 (36.6)	26 (63.4)	0.32	16 (39)	25 (61)	0.07	16 (39)	25 (61)	0.08
Male	22 (56.4)	17 (43.6)		24 (61.5)	15 (38.5)		23 (59)	16 (41)		23 (59)	16 (41)
Size (cm)*
<5.7	28 (63.6)	16 (36.4)	0.003	29 (65.9)	15 (34.1)	0.001	29 (65.9)	15 (34.1)	0.001	31 (70.5)	13 (29.5)	0.001
>5.7	11 (30.6)	25 (69.4)		10 (27.8)	26 (72.2)		10 (27.8)	26 (72.2)		8 (22.2 )	28 (77.8)
Grade*
Low	24 (68.6)	11 (31.4)	0.003	26 (74.3)	9 (25.7)	0.001	25 (71.4)	10 (28.6)	0.001	27 (77.1)	8 (22.9)	0.001
High	15 (33.3)	30 (66.7)		13 ( 28.9)	32 (71.1)		14 (31.1)	31 (68.9)		12 (28.9)	33 (73.3)
Depth of invasion
T1	17 (65.4)	9 (34.6)	0.8	16 (61.5)	10 (38.5)	0.23	17 (65.4)	9 (34.6)	0.8	14 (53.8)	12 (46.2)	0.65
T2	11 (55)	9 (45)		10 (50)	10 (50)		11 (55)	9 (45)		10 (50)	10 (50)
T3	6 (35.3)	11 (64.7)		8 (47.1)	9 (52.9)		6 (35.3)	11 (64.7)		9 (52.9)	8 (47.1)
T4	5 (29.4)	12 (70.6)		5 (29.4)	12 (70.6)		5 (29.4)	12 (70.6)		6 (35.3)	11 (64.7)
Lymph nodes*
N0	20 (60.6)	13 (39.4)	0.001	20 (60.6)	13 (39.4)	0.01	20 (60.6)	13 (39.4)	0.003	19 (54.5)	14 (45.5)	0.01
N1	16 (64)	9 (36)		14 (56)	11 (44)		15 (60)	10 (40)		14 (56)	11 (44)
N2	3 (13.6)	19 (86.4)		5 (22.7)	17 (77.3)		4 (18.2)	18 (81.8)		7 (31.8)	15 (68.2)
Distant metastasis*
Absent	16 (80)	4 (20)	0.001	12 (80)	8 (40)	0.001	15 (75)	5 (25)	0.007	14 (70)	6 (30)	0.007
Present	23 (38.3)	37 (61.7)		23 (38.3)	37 (61.7)		24 (40)	36 (60)		24 (40)	36 (60)