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Gastroenterology Research and Practice
Volume 2015, Article ID 568981, 10 pages
http://dx.doi.org/10.1155/2015/568981
Research Article

Molecular Mechanism of Local Drug Delivery with Paclitaxel-Eluting Membranes in Biliary and Pancreatic Cancer: New Application for an Old Drug

1Department of Internal Medicine, Gangnam Severance Hospital, Yonsei University College of Medicine, 712 Eonjuro, Gangnam-gu, Seoul 135-720, Republic of Korea
2Department of Internal Medicine, Kangnam Sacred Heart Hospital, Hallym University College of Medicine, Seoul, Republic of Korea
3Department of Bioevaluation Center, Korea Research Institute of Bioscience and Biotechnology, Cheongwon, Republic of Korea
4Department of Research and Development, Taewoong Medical Co., Gimpo, Republic of Korea
5Department of Biotechnology, The Catholic University, Bucheon, Republic of Korea
6Department of New Drug Development, School of Medicine, Inha University, Incheon, Republic of Korea
7Department of Internal Medicine, School of Medicine, Inha University, Incheon, Republic of Korea

Received 18 August 2014; Revised 6 October 2014; Accepted 7 October 2014

Academic Editor: Chunping Jiang

Copyright © 2015 Sookhee Bang et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Linked References

  1. H.-J. Wagner, K. Knyrim, N. Vakil, and K. J. Klose, “Plastic endoprostheses versus metal stents in the palliative treatment of malignant hilar biliary obstruction. A prospective and randomized trial,” Endoscopy, vol. 25, no. 3, pp. 213–218, 1993. View at Publisher · View at Google Scholar · View at Scopus
  2. A. C. Smith, J. F. Dowsett, R. C. G. Russell, A. R. W. Hatfield, and P. B. Cotton, “Randomised trial of endoscopic stenting versus surgical bypass in malignant low bileduct obstruction,” The Lancet, vol. 344, no. 8938, pp. 1655–1660, 1994. View at Publisher · View at Google Scholar · View at Scopus
  3. D. K. Lee, “Drug-eluting stent in malignant biliary obstruction,” Journal of Hepato-Biliary-Pancreatic Surgery, vol. 16, no. 5, pp. 628–632, 2009. View at Publisher · View at Google Scholar · View at Scopus
  4. D. K. Lee, H. S. Kim, K.-S. Kim et al., “The effect on porcine bile duct of a metallic stent covered with a paclitaxel-incorporated membrane,” Gastrointestinal Endoscopy, vol. 61, no. 2, pp. 296–301, 2005. View at Publisher · View at Google Scholar · View at Scopus
  5. K. T. Suk, J. W. Kim, H. S. Kim et al., “Human application of a metallic stent covered with a paclitaxel-incorporated membrane for malignant biliary obstruction: multicenter pilot study,” Gastrointestinal Endoscopy, vol. 66, no. 4, pp. 798–803, 2007. View at Publisher · View at Google Scholar · View at Scopus
  6. S. I. Jang, J. H. Kim, J. W. You et al., “Efficacy of a metallic stent covered with a paclitaxel-incorporated membrane versus a covered metal stent for malignant biliary obstruction: a prospective comparative study,” Digestive Diseases and Sciences, vol. 58, no. 3, pp. 865–871, 2013. View at Publisher · View at Google Scholar · View at Scopus
  7. M. Kalinowski, H. Alfke, B. Kleb, F. Dürfeld, and H. J. Wagner, “Paclitaxel inhibits proliferation of cell lines responsible for metal stent obstruction: possible topical application in malignant bile duct obstructions,” Investigative Radiology, vol. 37, no. 7, pp. 399–404, 2002. View at Publisher · View at Google Scholar · View at Scopus
  8. S. I. Jang, J.-H. Kim, M. Kim et al., “Porcine feasibility and safety study of a new paclitaxel-eluting biliary stent with a Pluronic-containing membrane,” Endoscopy, vol. 44, no. 9, pp. 825–831, 2012. View at Publisher · View at Google Scholar · View at Scopus
  9. M. A. Jordan, K. Wendell, S. Gardiner, W. B. Derry, H. Copp, and L. Wilson, “Mitotic block induced in HeLa cells by low concentrations of paclitaxel (taxol) results in abnormal mitotic exit and apoptotic cell death,” Cancer Research, vol. 56, no. 4, pp. 816–825, 1996. View at Google Scholar · View at Scopus
  10. P. B. Schiff and S. B. Horwitz, “Taxol stabilizes microtubules in mouse fibroblast cells,” Proceedings of the National Academy of Sciences of the United States of America, vol. 77, no. 3, pp. 1561–1565, 1980. View at Publisher · View at Google Scholar · View at Scopus
  11. D. Belotti, V. Vergani, T. Drudis et al., “The microtubule-affecting drug paclitaxel has antiangiogenic activity,” Clinical Cancer Research, vol. 2, no. 11, pp. 1843–1849, 1996. View at Google Scholar · View at Scopus
  12. D. H. Lau, L. Xue, L. J. Young, P. A. Burke, and A. T. Cheung, “Paclitaxel (Taxol): an inhibitor of angiogenesis in a highly vascularized transgenic breast cancer,” Cancer Biotherapy and Radiopharmaceuticals, vol. 14, no. 1, pp. 31–36, 1999. View at Publisher · View at Google Scholar · View at Scopus
  13. E. K. Rowinsky, “Paclitaxel pharmacology and other tumor types,” Seminars in Oncology, vol. 24, no. 6, supplement 19, pp. S19-1–S19-12, 1997. View at Google Scholar · View at Scopus
  14. M. Skwarczynski, Y. Hayashi, and Y. Kiso, “Paclitaxel prodrugs: toward smarter delivery of anticancer agents,” Journal of Medicinal Chemistry, vol. 49, no. 25, pp. 7253–7269, 2006. View at Publisher · View at Google Scholar · View at Scopus
  15. R. Liu, J. B. Wolinsky, P. J. Catalano et al., “Paclitaxel-eluting polymer film reduces locoregional recurrence and improves survival in a recurrent sarcoma model: a novel investigational therapy,” Annals of Surgical Oncology, vol. 19, no. 1, pp. 199–206, 2012. View at Publisher · View at Google Scholar · View at Scopus
  16. E. Gavathiotis, M. Suzuki, M. L. Davis et al., “BAX activation is initiated at a novel interaction site,” Nature, vol. 455, no. 7216, pp. 1076–1081, 2008. View at Publisher · View at Google Scholar · View at Scopus
  17. D. C. Huang and A. Strasser, “BH3-only proteins—essential initiators of apoptotic cell death,” Cell, vol. 103, no. 6, pp. 839–842, 2000. View at Publisher · View at Google Scholar · View at Scopus
  18. P.-C. Liao, S.-K. Tan, C.-H. Lieu, and H.-K. Jung, “Involvement of endoplasmic reticulum in paclitaxel-induced apoptosis,” Journal of Cellular Biochemistry, vol. 104, no. 4, pp. 1509–1523, 2008. View at Publisher · View at Google Scholar · View at Scopus
  19. H. Zinszner, M. Kuroda, X. Wang et al., “CHOP is implicated in programmed cell death in response to impaired function of the endoplasmic reticulum,” Genes and Development, vol. 12, no. 7, pp. 982–995, 1998. View at Publisher · View at Google Scholar · View at Scopus
  20. A. Fasolo and C. Sessa, “mTOR inhibitors in the treatment of cancer,” Expert Opinion on Investigational Drugs, vol. 17, no. 11, pp. 1717–1734, 2008. View at Publisher · View at Google Scholar · View at Scopus
  21. D. C. Fingar, C. J. Richardson, A. R. Tee, L. Cheatham, C. Tsou, and J. Blenis, “mTOR controls cell cycle progression through its cell growth effectors S6K1 and 4E-BP1/eukaryotic translation initiation factor 4E,” Molecular and Cellular Biology, vol. 24, no. 1, pp. 200–216, 2004. View at Publisher · View at Google Scholar · View at Scopus
  22. B. M. Wolpin, A. F. Hezel, T. Abrams et al., “Oral mTOR inhibitor everolimus in patients with gemcitabine-refractory metastatic pancreatic cancer,” Journal of Clinical Oncology, vol. 27, no. 2, pp. 193–198, 2009. View at Publisher · View at Google Scholar · View at Scopus
  23. S. C. Land and A. R. Tee, “Hypoxia-inducible factor 1α is regulated by the mammalian target of rapamycin (mTOR) via an mTOR signaling motif,” Journal of Biological Chemistry, vol. 282, no. 28, pp. 20534–20543, 2007. View at Publisher · View at Google Scholar · View at Scopus
  24. J. Yuan, R. Yan, A. Krämer et al., “Cyclin B1 depletion inhibits proliferation and induces apoptosis in human tumor cells,” Oncogene, vol. 23, no. 34, pp. 5843–5852, 2004. View at Publisher · View at Google Scholar · View at Scopus
  25. D. R. Senger, K. P. Claffey, J. E. Benes, C. A. Perruzzi, A. P. Sergiou, and M. Detmar, “Angiogenesis promoted by vascular endothelial growth factor: regulation through a1β1 and α2β1 integrins,” Proceedings of the National Academy of Sciences of the United States of America, vol. 94, no. 25, pp. 13612–13617, 1997. View at Publisher · View at Google Scholar · View at Scopus
  26. D. Hanahan and R. A. Weinberg, “Hallmarks of cancer: the next generation,” Cell, vol. 144, no. 5, pp. 646–674, 2011. View at Publisher · View at Google Scholar · View at Scopus
  27. V. Ellenrieder, B. Alber, U. Lacher et al., “Role of MT-MMPs and MMP-2 in pancreatic cancer progression,” International Journal of Cancer, vol. 85, no. 1, pp. 14–20, 2000. View at Google Scholar
  28. Y. He, G. D. Wu, T. Sadahiro et al., “Interaction of CD44 and hyaluronic acid enhances biliary epithelial proliferation in cholestatic livers,” The American Journal of Physiology—Gastrointestinal and Liver Physiology, vol. 295, no. 2, pp. G305–G312, 2008. View at Publisher · View at Google Scholar · View at Scopus
  29. C. Neuzillet, A. Tijeras-Raballand, J. Cros, S. Faivre, P. Hammel, and E. Raymond, “Stromal expression of SPARC in pancreatic adenocarcinoma,” Cancer and Metastasis Reviews, vol. 32, no. 3-4, pp. 585–602, 2013. View at Publisher · View at Google Scholar · View at Scopus
  30. Y. Sato, K. Harada, K. Itatsu et al., “Epithelial-mesenchymal transition induced by transforming growth factor-β1/snail activation aggravates invasive growth of cholangiocarcinoma,” The American Journal of Pathology, vol. 177, no. 1, pp. 141–152, 2010. View at Publisher · View at Google Scholar · View at Scopus
  31. D. Hanahan and R. A. Weinberg, “The hallmarks of cancer,” Cell, vol. 100, no. 1, pp. 57–70, 2000. View at Publisher · View at Google Scholar · View at Scopus
  32. A. Balsari, J. A. M. Maier, M. I. Colnaghi, and S. Ménard, “Correlation between tumor vascularity, vascular endothelial growth factor production by tumor cells, serum vascular endothelial growth factor levels, and serum angiogenic activity in patients with breast carcinoma,” Laboratory Investigation, vol. 79, no. 7, pp. 897–902, 1999. View at Google Scholar · View at Scopus
  33. G. Bergers and L. E. Benjamin, “Tumorigenesis and the angiogenic switch,” Nature Reviews Cancer, vol. 3, no. 6, pp. 401–410, 2003. View at Publisher · View at Google Scholar · View at Scopus
  34. J. Folkman and Y. Shing, “Angiogenesis,” Journal of Biological Chemistry, vol. 267, no. 16, pp. 10931–10934, 1992. View at Google Scholar · View at Scopus
  35. D. S. Grant, M. C. Kibbey, J. L. Kinsella, M. C. Cid, and H. K. Kleinman, “The role of basement membrane in angiogenesis and tumor growth,” Pathology Research and Practice, vol. 190, no. 9-10, pp. 854–863, 1994. View at Publisher · View at Google Scholar · View at Scopus
  36. K. Hara, Y. Maruki, X. Long et al., “Raptor, a binding partner of target of rapamycin (TOR), mediates TOR action,” Cell, vol. 110, no. 2, pp. 177–189, 2002. View at Publisher · View at Google Scholar · View at Scopus
  37. D. A. Guertin and D. M. Sabatini, “An expanding role for mTOR in cancer,” Trends in Molecular Medicine, vol. 11, no. 8, pp. 353–361, 2005. View at Publisher · View at Google Scholar · View at Scopus
  38. A. Efeyan and D. M. Sabatini, “MTOR and cancer: many loops in one pathway,” Current Opinion in Cell Biology, vol. 22, no. 2, pp. 169–176, 2010. View at Publisher · View at Google Scholar · View at Scopus
  39. J. J. Gibbons, R. T. Abraham, and K. Yu, “Mammalian target of rapamycin: discovery of rapamycin reveals a signaling pathway important for normal and cancer cell growth,” Seminars in Oncology, vol. 36, no. 3, pp. S3–S17, 2009. View at Publisher · View at Google Scholar · View at Scopus
  40. S.-Z. Lin, W.-T. Wei, H. Chen et al., “Antitumor activity of emodin against pancreatic cancer depends on its dual role: promotion of apoptosis and suppression of angiogenesis,” PLoS ONE, vol. 7, no. 8, Article ID e42146, 2012. View at Publisher · View at Google Scholar · View at Scopus
  41. G. Christofori, “New signals from the invasive front,” Nature, vol. 441, no. 7092, pp. 444–450, 2006. View at Publisher · View at Google Scholar · View at Scopus