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Gastroenterology Research and Practice
Volume 2015, Article ID 568981, 10 pages
Research Article

Molecular Mechanism of Local Drug Delivery with Paclitaxel-Eluting Membranes in Biliary and Pancreatic Cancer: New Application for an Old Drug

1Department of Internal Medicine, Gangnam Severance Hospital, Yonsei University College of Medicine, 712 Eonjuro, Gangnam-gu, Seoul 135-720, Republic of Korea
2Department of Internal Medicine, Kangnam Sacred Heart Hospital, Hallym University College of Medicine, Seoul, Republic of Korea
3Department of Bioevaluation Center, Korea Research Institute of Bioscience and Biotechnology, Cheongwon, Republic of Korea
4Department of Research and Development, Taewoong Medical Co., Gimpo, Republic of Korea
5Department of Biotechnology, The Catholic University, Bucheon, Republic of Korea
6Department of New Drug Development, School of Medicine, Inha University, Incheon, Republic of Korea
7Department of Internal Medicine, School of Medicine, Inha University, Incheon, Republic of Korea

Received 18 August 2014; Revised 6 October 2014; Accepted 7 October 2014

Academic Editor: Chunping Jiang

Copyright © 2015 Sookhee Bang et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Supplementary Material

The animal toxicity at each of these PEM was evaluated by weighing the mice. There were no deaths but some weight loss. Most of mice implanted with PEM experienced mild weight loss (<5%) during the 2 days after implantation. The mice began to regain weight 6 days after the PEM implantation. Therefore, based on observation of body weight no other host toxicities were observed.

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