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Research Article
Gastroenterology Research and Practice
Volume 2016, Article ID 7654280, 1 page
Letter to the Editor

Comment on “Characteristics and Risk Factors of Helicobacter pylori Associated Gastritis: A Prospective Cross-Sectional Study in Northeast Thailand”

Department of Bacteriology, Faculty of Medical Sciences, Tarbiat Modares University, P.O. Box 14115-111, Tehran, Iran

Received 30 March 2016; Accepted 15 June 2016

Academic Editor: Francesco Franceschi

Copyright © 2016 Amin Talebi Bezmin Abadi. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

We read with great interest the article by Tongtawee et al. concerning the analysis of 300 patients, who underwent esophagogastroduodenoscopy to investigate dyspeptic symptoms, who participated in this study from June 2014 to June 2015 [1]. However, some considerations we found can improve further research in current field. Infection with Helicobacter pylori (H. pylori) induces chronic inflammation in the human gastric microniche; moreover, H. pylori-related gastritis is highly linked with the development of gastric adenocarcinoma [2].(1)Genetic polymorphisms of Mdm2 SNIP309 are not valid enough to determine susceptibility of H. pylori infected individuals to the gastritis or even other gastroduodenal disorders. However, finding a significant association between a clinical disorder and a certain genotype requires a complex molecular investigation with considering various challenging elements.(2)Various types of gastritis described by Sydney standards should be mentioned; otherwise, data need to be recalculated. Thus, current question asked by authors requires more details to be answered.(3)The main limitation in this article is to analyze new biomarker in gastric cancer patients where this disease is not frequent. To examine and draw a better conclusion out of primary results by the authors, they need to investigate their results in a region with higher rate of gastric cancer.

Competing Interests

The author has declared that no competing interests exist.


  1. T. Tongtawee, S. Kaewpitoon, N. Kaewpitoon et al., “Characteristics and risk factors of Helicobacter pylori associated gastritis: a prospective cross-sectional study in Northeast Thailand,” Gastroenterology Research and Practice, vol. 2016, Article ID 9130602, 8 pages, 2016. View at Publisher · View at Google Scholar
  2. L. E. Wroblewski, R. M. Peek Jr., and K. T. Wilson, “Helicobacter pylori and gastric cancer: factors that modulate disease risk,” Clinical Microbiology Reviews, vol. 23, no. 4, pp. 713–739, 2010. View at Publisher · View at Google Scholar · View at Scopus