(iii) Endothelial dysfunction induced by mechanical and systemic factors
(iv) Venous stasis
(v) Acquired risk factors (prolonged hospitalization, surgical interventions, central venous catheters, prolonged immobilization and bed rest, glucocorticoids, smoking, oral contraceptives, vitamin deficiencies, dehydration, hormone replacement therapy, and hyperhomocysteinemia)
(vi) Genetic risk factors (dysfibrinogenemias, prothrombin gene mutation, factor V Leiden thrombophilia, and deficiency of proteins C, S, and antithrombin)
Arterial thromboembolism
(i) Structural and functional vascular alterations induced by chronic systemic inflammation
(ii) Accelerated development of atherosclerosis and highly unstable atherosclerotic plaques
(iii) Endothelial dysfunction induced by microbial lipopolysaccharides
(iv) Altered gut microbiota
(v) Adipokines
(vi) Calprotectin
(vii) NOD2/CARD15 gene polymorphism
(viii) Dyslipidemia
Heart failure
(i) Myocardial fibrosis secondary to altered collagen metabolism, impaired nitric oxide-mediated vasodilation, and deficiencies of vitamins and essential trace elements