Research Article

Neuroendocrine Neoplasms of the Gallbladder: A Clinicopathological Analysis of 13 Patients and a Review of the Literature

Table 4

Characteristics of 41 previously reported patients with GB-MiNENs, including our current 9 patients.

Total number of patients41
SexMale: 12 (12/41, 29.2%)
Female: 29 (29/41, 70.7%)
Female-to-male ratio: 2.4 : 1
Median age60 years (age range: 34-85 years)
Primary tumor locationGallbladder
Tumor siteFundus: 16 (16/29, 55.2%)
Body: 5 (7/29, 24.1%)
Neck: 4 (4/29, 13.8%)
Fundus and body: 2 (2/29, 6.9%)
Metastatic siteLymph nodes: 15 (15/41, 36.6%)
Liver: 17 (17/41, 41.5%)
Duodenum: 1 (1/41, 2.4%)
Bone: 1 (1/41, 2.4%)
Presenting symptomsAbdominal pain: 22 (22/35, 62.9%)
Fever: 2 (2/35, 5.7%)
Back pain: 3 (3/35, 8.5%)
Asymptomatic: 7 (7/35, 20.0%)
Anorexia: 1 (1/35, 2.9%)
MorphologyProtruding: 27 (27/36, 75.0%)
Infiltrative: 9 (9/36, 25.0%)
Histopathology of the neuroendocrine componentSCC: 9 (9/41, 22.0%)
LCNEC: 19 (19/41, 46.3%)
SCC and LCNEC: 1 (1/41, 2.4%)
NEC: 6 (6/41, 14.6%)
NET: G2, 4 (4/41, 9.8%)
Amphicrine carcinoma: 2 (2/41, 4.9%)
OutcomeMedian survival: 11.5 months (range: 2-40 months)
Median disease-free survival: 12 months (range: 2-48 months)