Neuroendocrine Neoplasms of the Gallbladder: A Clinicopathological Analysis of 13 Patients and a Review of the Literature

Table 6

The Cox regression and univariate and multivariate analyses of GB-MiNENs.

Parameter	Univariate analysis		Multivariate analysis
	HR (95% CI)	value	HR (95% CI)	value
Age	0.983 (0.945-1.023)	0.394
Sex (male vs. female)	0.576 (0.202-1.641)	0.301
Tumor diameter	1.295 (0.904-1.855)	0.159	1.525 (0.969-2.402)	0.068
Grade of the neuroendocrine component (NET vs. NEC)	1.531 (0.199-11.754)	0.682
Lymph node metastasis (negative vs. positive)	1.754 (0.547-5.628)	0.345
Liver metastasis (negative vs. positive)	4.364 (1.503-12.673)		4.262 (1.066-17.044)
Tumor stage (stages I + II vs. stages III + IV)	3.028 (0.961-9.545)	0.059	1.341 (0.322-5.582)	0.686
Adjuvant chemotherapy	1.020 (0.355-2.933)	0.971

Variables with in the univariate analysis were included in the multivariate analysis. .