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International Journal of Analytical Chemistry
Volume 2017 (2017), Article ID 1271383, 11 pages
https://doi.org/10.1155/2017/1271383
Research Article

New Modified UPLC/Tandem Mass Spectrometry Method for Determination of Risperidone and Its Active Metabolite 9-Hydroxyrisperidone in Plasma: Application to Dose-Dependent Pharmacokinetic Study in Sprague-Dawley Rats

1Pharmaceutical Chemistry Department and Drug Bioavailability Laboratory, College of Pharmacy, King Saud University, P.O. Box 2457, Riyadh 11451, Saudi Arabia
2Drug Bioavailability Center, National Organization for Drug Control and Research, P.O. Box 29, Cairo, Egypt

Correspondence should be addressed to Marwa Tammam; moc.liamg@awram.mammat

Received 4 January 2017; Revised 28 February 2017; Accepted 16 March 2017; Published 3 May 2017

Academic Editor: David M. Lubman

Copyright © 2017 Essam Ezzeldin et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

How to Cite this Article

Essam Ezzeldin, Marwa Tammam, and Nisreen F. Abo Talib, “New Modified UPLC/Tandem Mass Spectrometry Method for Determination of Risperidone and Its Active Metabolite 9-Hydroxyrisperidone in Plasma: Application to Dose-Dependent Pharmacokinetic Study in Sprague-Dawley Rats,” International Journal of Analytical Chemistry, vol. 2017, Article ID 1271383, 11 pages, 2017. doi:10.1155/2017/1271383