New Modified UPLC/Tandem Mass Spectrometry Method for Determination of Risperidone and Its Active Metabolite 9-Hydroxyrisperidone in Plasma: Application to Dose-Dependent Pharmacokinetic Study in Sprague-Dawley Rats

Table 3

Intra- and interday precision and accuracy of 9-OH-RIS in rat plasma.

Theoretical conc.; (ng/mL)	Intraday			Interday
	Measured conc. (ng/mL); (mean ± SD)	Precision (CV%)	Accuracy (%)	Measured conc. (ng/mL); (mean ± SD)	Precision (CV%)	Accuracy (%)
0.2	0.19 ± 0.01	9.11	95.00	0.22 ± 0.08	5.11	110.00
2	2.1 ± 0.02	3.77	105.00	1.95 ± 0.39	8.45	97.50
20	19.39 ± 1.51	5.88	96.95	20.1 ± 1.27	7.98	100.50
400	392 ± 2.35	7.57	98.00	395 ± 0.07	4.35	98.75