New Modified UPLC/Tandem Mass Spectrometry Method for Determination of Risperidone and Its Active Metabolite 9-Hydroxyrisperidone in Plasma: Application to Dose-Dependent Pharmacokinetic Study in Sprague-Dawley Rats

Table 6

Mean pharmacokinetic parameters (mean ± SD) of RIS and 9-OH-RIS following administration of different doses of RIS to rats.

Dose (mg/kg)

(ng/ml)

(h)

(ng·h/ml)

(ng·h/ml)

(h)

MRT (h)

(h)

RIS

9-OH-RIS

RIS

9-OH-RIS

RIS

9-OH-RIS

RIS

9-OH-RIS

RIS

9-OH-RIS

RIS

9-OH-RIS

RIS

9-OH-RIS

0.3

11.96 ± 2.4

7.95 ± 1.6

0.5

1.0

32.52 ± 0.5

79.9 ± 1.6

38.15 ± 2.2

102.8 ± 43.7

1.21 ± 0.3

17.9 ± 17.04

2.63 ± 0.4

0.075 ± 0.03

0.59 ± 0.2

12.9 ± 10.6

1.0

27.37 ± 3.5

15.92 ± 4.05

0.5

0.5

101.81 ± 8.5

95.7 ± 28.1

126.01 ± 12.2

97.2 ± 28.1

9.53 ± 2.7

8.1 ± 1.8

13.09 ± 3.9

0.11 ± 0.04

0.08 ± 0.01

6.5 ± 1.8

6.0

125.09 ± 2.4

14.6 ± 0.46

1.0

1.0

1914.83 ± 49.6

120.34 ± 24.6

3094.49 ± 360.4

179.96 ± 9.2

43.62 ± 7.7

32.4 ± 3.09

51.88 ± 9.8

0.02 ± 0.002

0.02 ± 0.003

25.16 ± 2.3

Median for