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International Journal of Analytical Chemistry
Volume 2017, Article ID 8215271, 16 pages
Review Article

Dispersive Solid Phase Extraction for the Analysis of Veterinary Drugs Applied to Food Samples: A Review

1Área Académica de Química, Universidad Autónoma del Estado de Hidalgo, Carretera Pachuca-Tulancingo Km 4.5, 42076 Pachuca, HGO, Mexico
2Área de Energías, Universidad Politécnica de Francisco I. Madero, Domicilio Conocido, 42640 Tepatepec, HGO, Mexico
3Departamento de Química Analítica, Nutrición y Bromatología, Facultad de Veterinaria, Universidade de Santiago de Compostela, Pabellón 4 Planta Baja, Campus Universitario, s/n, 27002 Lugo, Spain

Correspondence should be addressed to Israel S. Ibarra; moc.liamg@heau.oisi

Received 21 April 2017; Revised 16 August 2017; Accepted 29 August 2017; Published 18 October 2017

Academic Editor: Neil D. Danielson

Copyright © 2017 Gabriela Islas et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


To achieve analytical success, it is necessary to develop thorough clean-up procedures to extract analytes from the matrix. Dispersive solid phase extraction (DSPE) has been used as a pretreatment technique for the analysis of several compounds. This technique is based on the dispersion of a solid sorbent in liquid samples in the extraction isolation and clean-up of different analytes from complex matrices. DSPE has found a wide range of applications in several fields, and it is considered to be a selective, robust, and versatile technique. The applications of dispersive techniques in the analysis of veterinary drugs in different matrices involve magnetic sorbents, molecularly imprinted polymers, carbon-based nanomaterials, and the Quick, Easy, Cheap, Effective, Rugged, and Safe (QuEChERS) method. Techniques based on DSPE permit minimization of additional steps such as precipitation, centrifugation, and filtration, which decreases the manipulation of the sample. In this review, we describe the main procedures used for synthesis, characterization, and application of this pretreatment technique and how it has been applied to food analysis.