Research Article
Green Analytical Methods for the Separation of Seven Antihistamines: Application in Separation of Azelastine and Related Impurities in Nasal Solution
Table 3
Eco-scale scores for proposed methods for analysis of FEX, EB, LOR, DESL, AZE, KET, and OLO (adopted from [
18,
19]).
| | Factor | Penalty points |
| | Reagents (HCl) | 8 |
| | Acetonitrile | 4 |
| | Instruments (HPLC) | 1 |
| | Occupational hazards | 3 |
| | Waste | 8 |
| | Total penalty points | 24 |
| | Analytical Eco-Scale total score | 76 |
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