Determination of Methomyl Residue in Tobacco Samples by Heart-Cutting Two-Dimensional Liquid Chromatography with Tandem Mass Spectrometry

Table 4

Comparison of the proposed method with other developed methods for the determination of methomyl.

	Method
Item	LC-MS/MS	LC-MS/MS	LC-MS/MS	2D-LC-MS/MS
Samples	Tea	Citrus fruits	Blood and brain tissue	Tobacco
Sample pretreatment	Matrix solid phase dispersion and concentration	Liquid extraction and concentration	QuEChERS	Simplified QuEChERS
Linear range	1–500 ng/L	0.010–0.150 mg/kg	0.5–500 ng/g	2.5–500 ng/mL
LOD	0.55 ng/g	0.2 μg/kg	0.1 ng/mL in blood and 0.2 ng/g in brain	0.69 ng/mL
RSD	1.3–3.4%	1–11%	4.0–22% for blood and 3.0–14% for brain	5.1%
Recovery	94.8–98.2%	98–103%	90–101% for blood and 84–121% for brain	93.1–108.2%
Ref.	[9]	[11]	[18]	Proposed method