Research Article
Determination of Methomyl Residue in Tobacco Samples by Heart-Cutting Two-Dimensional Liquid Chromatography with Tandem Mass Spectrometry
Table 4
Comparison of the proposed method with other developed methods for the determination of methomyl.
| | Method | Item | LC-MS/MS | LC-MS/MS | LC-MS/MS | 2D-LC-MS/MS |
| Samples | Tea | Citrus fruits | Blood and brain tissue | Tobacco | Sample pretreatment | Matrix solid phase dispersion and concentration | Liquid extraction and concentration | QuEChERS | Simplified QuEChERS | Linear range | 1–500 ng/L | 0.010–0.150 mg/kg | 0.5–500 ng/g | 2.5–500 ng/mL | LOD | 0.55 ng/g | 0.2 μg/kg | 0.1 ng/mL in blood and 0.2 ng/g in brain | 0.69 ng/mL | RSD | 1.3–3.4% | 1–11% | 4.0–22% for blood and 3.0–14% for brain | 5.1% | Recovery | 94.8–98.2% | 98–103% | 90–101% for blood and 84–121% for brain | 93.1–108.2% | Ref. | [9] | [11] | [18] | Proposed method |
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