A Rapid Screening Method for Sibutramine Hydrochloride in Natural Herbal Medicines and Dietary Supplements

Table 9

The determination of adjusted detection limit.

Sample	Content of sibutramin hydrochloride (mg per aliquot)	Precipitate formed
1	0	No
2	0.036	No
3	0.045	No
4	0.054	Not sure
5	0.112	Yes
6	0.224	Yes
7	0.447	Yes

According to the results listed in Table 9, the LOD is 0.112 mg of sibutramine hydrochloride per aliquot for this method. The method is simple and rational. Aliquot: a certain amount of sample may vary from 0.1 to 0.5 g.