Gender-Specific Neuroimmunoendocrine Response to Treadmill Exercise in 3xTg-AD Mice

Figure 1

All the behavioral tests do consistently refer to presence of BPSD-like symptoms as a characteristic of early stages of the disease in 3xTg-AD mice, with an important gender component. The effects of exercise are gender dependent. (a) The neophobia in the corner test was increased in both male and female 3xTg-AD mice. (b and c) The anxious profile could be also observed in several variables measured by the open-field test and dark-light box. (d) In the Morris water maze, changes in the swim speed and motivation could be recorded and were mainly important in females (see complementary data in Tables 1(a) and 1(b)). Values are the mean ± SEM, 𝑛=8-10. Statistics: ^∗𝑃<.05, ^∗∗𝑃<.01, and ^∗∗∗𝑃<.001 compared to the corresponding non-Tg;^#𝑃<.05, ^##𝑃<.01 compared to the corresponding TgSED.

(a)

(b)

(c)

(d)