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International Journal of Alzheimer’s Disease
Volume 2010, Article ID 576357, 5 pages
Research Article

Grape-Seed Polyphenolic Extract Improves the Eye Phenotype in a Drosophila Model of Tauopathy

1Department of Oncological Sciences, Mount Sinai School of Medicine, One Gustave L. Levy Place, NY 10029, USA
2Department of Neurology, The Mount Sinai School of Medicine, One Gustave L. Levy Place, NY 10029, USA
3James J. Peters Veteran Affairs Medical Center, 130 West Kingsbridge Road, Bronx, NY 10468, USA

Received 8 April 2010; Revised 24 June 2010; Accepted 9 July 2010

Academic Editor: Gemma Casadesus

Copyright © 2010 Cathie M. Pfleger et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


Drosophila models of tauopathies have been developed by transgenically overexpressing the disease-associated forms of tau. In this paper we report for the first time that a recently developed Grape-Seed Polyphenolic Extract (GSPE) improves the eye phenotype of a Drosophila eye model of R406W tau. GSPE-mediated improvements in this distinct in vivo neurodegeneration model for protein misfolding/aggregation suggest that GSPE may have therapeutic value in disorders involving aberrant protein aggregation.