Table of Contents Author Guidelines Submit a Manuscript
International Journal of Alzheimer’s Disease
Volume 2010 (2010), Article ID 723782, 6 pages
Review Article

Neuron Loss in Transgenic Mouse Models of Alzheimer's Disease

Division of Molecular Psychiatry and Alzheimer Ph.D. Graduate School, Department of Psychiatry, University of Goettingen, von-Siebold-Str. 5, 37075 Goettingen, Germany

Received 3 May 2010; Revised 5 July 2010; Accepted 9 July 2010

Academic Editor: Gemma Casadesus

Copyright © 2010 Oliver Wirths and Thomas A. Bayer. This is an open access article distributed under the Creative Commons Attribution Licensee, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


Since their initial generation in the mid 1990s, transgenic mouse models of Alzheimers's disease (AD) have been proven to be valuable model systems which are indispensable for modern AD research. Whereas most of these models are characterized by extensive amyloid plaque pathology, inflammatory changes and often behavioral deficits, modeling of neuron loss was much less successful. The present paper discusses the current achievements of modeling neuron loss in transgenic mouse models based on APP/A and Tau overexpression and provides an overview of currently available AD mouse models showing these pathological alterations.