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International Journal of Alzheimer’s Disease
Volume 2011, Article ID 231595, 6 pages
Research Article

Ceruloplasmin/Transferrin Ratio Changes in Alzheimer's Disease

1Department of Neuroscience, AFaR—Fatebenefratelli Hospital, 00186 Rome, Italy
2Department of Neurology, Campus Bio-Medico University, 00128 Rome, Italy
3Institute of Cognitive Sciences and Technologies (CNR), Fatebenefratelli Hospital, 00186 Rome, Italy
4Department of Radiology, Fatebenefratelli Hospital, 00186 Rome, Italy
5Department of Imaging, San Raffaele Cassino, Via G. Di Biasio 1, 03043 Cassino(FR), Italy

Received 24 September 2010; Accepted 22 November 2010

Academic Editor: Anthony R. White

Copyright © 2011 Rosanna Squitti et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


The link between iron and Alzheimer's disease (AD) has been mainly investigated with a focus on the local accumulation of this metal in specific areas of the brain that are critical for AD. In the present study, we have instead looked at systemic variations of markers of iron metabolism. We measured serum levels of iron, ceruloplasmin, and transferrin and calculated the transferrin saturation and the ceruloplasmin to transferrin ratio (Cp/Tf). Cp/Tf and transferrin saturation increased in AD patients. Cp/Tf ratios also correlated positively with peroxide levels and negatively with serum iron concentrations. Elevated values of ceruloplasmin, peroxides, and Cp/Tf inversely correlated with MMSE scores. Isolated medial temporal lobe atrophy positively correlated with Cp/Tf and negatively with serum iron. All these findings indicate that the local iron accumulation found in brain areas critical for AD should be viewed in the frame of iron systemic alterations.