Recent Development of Bifunctional Small Molecules to Study Metal-Amyloid-β Species in Alzheimer's Disease
Figure 5
Chemical structures of small molecules (a) HBX/HBXI, HBT/HBTI, and BM/BMI, (b) 1, and (c) 2 that were constructed employing Approach II (Figure 3) (HBX = 2-(2-hydroxyphenyl)benzoxazole; HBT = 2-(2-hydroxyphenyl)benzothiazole; BM = 2-(2-aminophenyl)benzimidazole; 1 = 2-[4-(dimethylamino)phenyl]imidazo[1,2-a]pyridine-8-ol; 2 = N 1,N 1-dimethyl-N 4-(pyridin-2-ylmethylene)benzene-1,4-diamine).
