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International Journal of Alzheimer’s Disease
Volume 2012, Article ID 687909, 5 pages
http://dx.doi.org/10.1155/2012/687909
Review Article

Effect of Transcranial Brain Stimulation for the Treatment of Alzheimer Disease: A Review

1Department of Neurology, Christian Doppler Clinic, Paracelsus Medical University, 5020 Salzburg, Austria
2Department of Neurology, Franz Tappeiner Hospital, Via Rossini 5, 39012 Meran/o, Italy
3Neuroscience Institute, Christian Doppler Clinic, 5020 Salzburg, Austria
4Department of Physiology, Medical University of Graz, 8010 Graz, Austria

Received 30 July 2011; Accepted 26 August 2011

Academic Editor: Anil Nair

Copyright © 2012 Raffaele Nardone et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Citations to this Article [63 citations]

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  • Sonia C. P. Sousa, Jorge Almeida, Pedro Cavaleiro Miranda, Ricardo Salvador, Joao Silvestre, Hugo Simoes, and Paulo Crespo, “Optimization of multiple coils immersed in a conducting liquid for half-hemisphere or whole-brain deep transcranial magnetic stimulation: A simulation study,” 2014 36th Annual International Conference of the IEEE Engineering in Medicine and Biology Society, pp. 538–541, . View at Publisher · View at Google Scholar
  • David E. Vance, Joan E. Dodson, Carrie Ann Gakumo, David Morris, Beth Kitchin, and Kerstin E. E. Schroder, “Successful cognitive aging in HIV: Potential strategies for treatment and research,” Physical and Occupational Therapy in Geriatrics, vol. 30, no. 3, pp. 229–244, 2012. View at Publisher · View at Google Scholar
  • Kristin M. Pearson-Fuhrhop, Erin Burke, and Steven C. Cramer, “The influence of genetic factors on brain plasticity and recovery after neural injury,” Current Opinion in Neurology, vol. 25, no. 6, pp. 682–688, 2012. View at Publisher · View at Google Scholar
  • Jose M. Rabey, Evgenia Dobronevsky, Sergio Aichenbaum, Ofer Gonen, Revital Gendelman Marton, and Michael Khaigrekht, “Repetitive transcranial magnetic stimulation combined with cognitive training is a safe and effective modality for the treatment of Alzheimer’s disease: a randomized, double-blind study,” Journal of Neural Transmission, vol. 120, no. 5, pp. 813–819, 2012. View at Publisher · View at Google Scholar
  • Gary W. Arendash, “Transcranial Electromagnetic Treatment Against Alzheimer's Disease: Why it has the Potential to Trump Alzheimer's Disease Drug Development,” Journal Of Alzheimers Disease, vol. 32, no. 2, pp. 243–266, 2012. View at Publisher · View at Google Scholar
  • Alessandro Trebbastoni, Ruggero Raccah, Carlo de Lena, Abraham Zangen, and Maurizio Inghilleri, “Repetitive Deep Transcranial Magnetic Stimulation Improves Verbal Fluency and Written Language in a Patient with Primary Progressive Aphasia-Logopenic Variant (LPPA),” Brain Stimulation, vol. 6, no. 4, pp. 545–553, 2013. View at Publisher · View at Google Scholar
  • Bruce Luber, and Sarah H. Lisanby, “Enhancement of human cognitive performance using transcranial magnetic stimulation (TMS),” NeuroImage, 2013. View at Publisher · View at Google Scholar
  • Surjo R. Soekadar, Matthias Witkowski, Eliana G. Cossio, Niels Birbaumer, Stephen E. Robinson, and Leonardo G. Cohen, “In vivo assessment of human brain oscillations during application of transcranial electric currents,” Nature Communications, vol. 4, 2013. View at Publisher · View at Google Scholar
  • Juliana Cardoso De Souza Custódio, Cleciane Waldetário Martins, Marcelo Di Marcello Valladão Lugon, Felipe Fregni, and Ester Miyuki Nakamura-Palacios, “Epidural direct current stimulation over the left medial prefrontal cortex facilitates spatial working memory performance in rats,” Brain Stimulation, vol. 6, no. 3, pp. 261–269, 2013. View at Publisher · View at Google Scholar
  • Christopher N David, Judith L Rapoport, and Nitin Gogtay, “Treatments in context: transcranial direct current brain stimulation as a potential treatment in pediatric psychosis,” Expert Review of Neurotherapeutics, vol. 13, no. 4, pp. 447–458, 2013. View at Publisher · View at Google Scholar
  • Andrew F. Leuchter, Ian A. Cook, Yi Jin, and Bill Phillips, “The relationship between brain oscillatory activity and therapeutic effectiveness of transcranial magnetic stimulation in the treatment of major depressive disorder,” Frontiers In Human Neuroscience, vol. 7, 2013. View at Publisher · View at Google Scholar
  • Sibylle C. Herholz, Regina S. Herholz, and Karl Herholz, “Non-pharmacological interventions and neuroplasticity in early stage Alzheimer's disease,” Expert Review of Neurotherapeutics, vol. 13, no. 11, pp. 1235–1245, 2013. View at Publisher · View at Google Scholar
  • Claudia Kimie Suemoto, Daniel Apolinario, Ester Miyuki Nakamura-Palacios, Leonardo Lopes, Renata Elaine Paraizo Leite, Manuela Castro Sales, Ricardo Nitrini, Sonia Maria Brucki, Lilian Shafirovitz Morillo, Regina Miksian Magaldi, and Felipe Fregni, “Effects of a non-focal plasticity protocol on apathy in moderate Alzheimer's disease: a randomized, double-blind, sham-controlled trial,” Brain Stimulation, 2013. View at Publisher · View at Google Scholar
  • Lindsay M. Oberman, Alexander Rotenberg, and Alvaro Pascual-Leone, “Use of Transcranial Magnetic Stimulation in Autism Spectrum Disorders,” Journal of Autism and Developmental Disorders, 2013. View at Publisher · View at Google Scholar
  • Luca Peruzzotti-Jametti, Marco Bacigaluppi, Stefano Sandrone, and Marco Cambiaghi, “Emerging Subspecialties in Neurology: Transcranial stimulation,” Neurology, vol. 80, no. 4, pp. e33–e35, 2013. View at Publisher · View at Google Scholar
  • Carsten Finke, Hannah Bruehl, Emrah Duezel, Hauke R. Heekeren, and Christoph J. Ploner, “Neural Correlates of Short-Term Memory Reorganization in Humans with Hippocampal Damage,” Journal Of Neuroscience, vol. 33, no. 27, pp. 11061–11069, 2013. View at Publisher · View at Google Scholar
  • M. R. Ljubisavljevic, F. Y. Ismail, and S. Filipovic, “Transcranial Magnetic Stimulation of Degenerating Brain: A Comparison of Normal Aging, Alzheimer's, Parkinson's and Huntington's Disease,” Current Alzheimer Research, vol. 10, no. 6, pp. 578–596, 2013. View at Publisher · View at Google Scholar
  • John V. Hindle, Elke Kalbe, Annette Petrelli, and Linda Clare, “Nonpharmacological enhancement of cognitive function in Parkinson's disease: A systematic review,” Movement Disorders, vol. 28, no. 8, pp. 1034–1049, 2013. View at Publisher · View at Google Scholar
  • Grant Rutherford, Rebecca Gole, and Zahra Moussavi, “rTMS as a Treatment of Alzheimer’s Disease with and without Comorbidity of Depression: A Review,” Neuroscience Journal, vol. 2013, pp. 1–5, 2013. View at Publisher · View at Google Scholar
  • Kyrana Tsapkini, Constantine Frangakis, Yessenia Gomez, Cameron Davis, and Argye E. Hillis, “Augmentation of spelling therapy with transcranial direct current stimulation in primary progressive aphasia: Preliminary results and challenges,” Aphasiology, vol. 28, no. 8-9, pp. 1112–1130, 2014. View at Publisher · View at Google Scholar
  • Zhiqiang Meng, Chang Liu, Chengyang Yu, and Yuanye Ma, “Transcranial direct current stimulation of the frontal-parietal-temporal area attenuates smoking behavior,” Journal of Psychiatric Research, vol. 54, pp. 19–25, 2014. View at Publisher · View at Google Scholar
  • Geoffrey Grammer, Vanessa Green, Rohul Amin, and Miguel Alampay, “The Role of rTMS in the Treatment of Psychiatric Disorders Other than Major Depression,” Psychiatric Annals, vol. 44, no. 6, pp. 293–298, 2014. View at Publisher · View at Google Scholar
  • Lubomira Anderkova, and Irena Rektorova, “Cognitive effects of repetitive transcranial magnetic stimulation in patients with neurodegenerative diseases - Clinician's perspective,” Journal of The Neurological Sciences, vol. 339, no. 1-2, pp. 15–25, 2014. View at Publisher · View at Google Scholar
  • Samantha Holden, “Treatment of Psychosis and Dementia in Parkinson's Disease,” Current Treatment Options in Neurology, vol. 16, no. 3, 2014. View at Publisher · View at Google Scholar
  • Alireza Shahbabaie, Mehrshad Golesorkhi, Behnam Zamanian, Mitra Ebrahimpoor, Fatemeh Keshvari, Vahid Nejati, Felipe Fregni, and Hamed Ekhtiari, “State dependent effect of transcranial direct current stimulation (tDCS) on methamphetamine craving,” International Journal of Neuropsychopharmacology, vol. 17, no. 10, pp. 1591–1598, 2014. View at Publisher · View at Google Scholar
  • Indra T. Mahayana, Dwi C. R. Sari, Chiao-Yun Chen, Chi-Hung Juan, and Neil G. Muggleton, “The potential of transcranial magnetic stimulation for population-based application: a region-based illustrated brief overview,” International Journal of Neuroscience, vol. 124, no. 10, pp. 717–723, 2014. View at Publisher · View at Google Scholar
  • David E. Vance, Graham J. McDougall, Natalie Wilson, Marcus Otavio Debiasi, and Shameka L. Cody, “Cognitive Consequences of Aging With HIV Implications for Neuroplasticity and Rehabilitation,” Topics in Geriatric Rehabilitation, vol. 30, no. 1, pp. 35–45, 2014. View at Publisher · View at Google Scholar
  • Rosaria Lupica, Antonio Lacquaniti, Valeria Cernaro, Silvia Lucisano, Michele Buemi, Valentina Donato, and Giovanni Grasso, “Proteinuric effect of transcranial magnetic stimulation in healthy subjects and diabetic patients with Stage 3-4 CKD,” Nephrology Dialysis Transplantation, vol. 29, no. 3, pp. 573–579, 2014. View at Publisher · View at Google Scholar
  • Nicholas S. Fitz, and Peter B. Reiner, “The Perils of Using Electrical Stimulation to Change Human Brains,” The Stimulated Brain, pp. 61–83, 2014. View at Publisher · View at Google Scholar
  • Maximo Zimerman, and Friedhelm C. Hummel, “Brain Stimulation and its Role in Neurological Diseases,” The Stimulated Brain, pp. 333–369, 2014. View at Publisher · View at Google Scholar
  • Francesca Mameli, Manuela Fumagalli, Roberta Ferrucci, and Alberto Priori, “Transcranial Direct Current Stimulation and Cognition in the Elderly,” The Stimulated Brain, pp. 371–395, 2014. View at Publisher · View at Google Scholar
  • Hong Yuan, Serik Tabarak, Jing Yu, and Xu Lei, “Transcranial direct current stimulation in patients with Alzheimer's disease: Challenges and responses,” ADMET and DMPK, vol. 3, no. 3, pp. 235–241, 2015. View at Publisher · View at Google Scholar
  • Naomi Nevler, and Elissa L. Ash, “TMS as a Tool for Examining Cognitive Processing,” Current Neurology And Neuroscience Reports, vol. 15, no. 8, 2015. View at Publisher · View at Google Scholar
  • Donna C. Tippett, Argye E. Hillis, and Kyrana Tsapkini, “Treatment of Primary Progressive Aphasia,” Current Treatment Options in Neurology, vol. 17, no. 8, 2015. View at Publisher · View at Google Scholar
  • Priyadharshini Sabesan, Sudheer Lankappa, Najat Khalifa, Vasudevan Krishnan, Rahul Gandhi, and Lena Palaniyappan, “Transcranial magnetic stimulation for geriatric depression: Promises and pitfalls.,” World journal of psychiatry, vol. 5, no. 2, pp. 170–81, 2015. View at Publisher · View at Google Scholar
  • Tommaso Piccoli, Giancarlo Valente, David E. J. Linden, Marta Re, Fabrizio Esposito, Alexander T. Sack, and Francesco Di Salle, “The Default Mode Network and the Working Memory Network Are Not Anti-Correlated during All Phases of a Working Memory Task,” Plos One, vol. 10, no. 4, 2015. View at Publisher · View at Google Scholar
  • Ying-hui Chou, Hui You, Han Wang, Yan-Ping Zhao, Bo Hou, Nan-Kuei Chen, and Feng Feng, “Effect of Repetitive Transcranial Magnetic Stimulation on fMRI Resting-State Connectivity in Multiple System Atrophy,” Brain Connectivity, pp. 150318064018004, 2015. View at Publisher · View at Google Scholar
  • Hua-Long Wang, Xiao-Hui Xian, Yan-Yong Wang, Yuan Geng, Bing Han, Ming-Wei Wang, and Wen-Bin Li, “Chronic high-frequency repetitive transcranial magnetic stimulation improves age-related cognitive impairment in parallel with alterations in neuronal,” Neurobiology Of Learning And Memory, vol. 118, pp. 1–7, 2015. View at Publisher · View at Google Scholar
  • C. Estrada, D. Lopez, A. Conesa, F. J. Fernandez-Gomez, A. Gonzalez-Cuello, F. Toledo, I. Tunez, O. Blin, R. Bordet, J. C. Richardson, E. Fernandez-Villalba, and M. T. Herrero, “Cognitive Impairment After Sleep Deprivation Rescued by Transcranial Magnetic Stimulation Application in Octodon degus,” Neurotoxicity Research, vol. 28, no. 4, pp. 361–371, 2015. View at Publisher · View at Google Scholar
  • Steven A. Connor, and Peter V. Nguyenpp. 173–196, 2015. View at Publisher · View at Google Scholar
  • Anna Poleszczyk, “Transcranial magnetic stimulation in treatment of various psychiatric disorders - Review of the most prominent studies and the latest news,” Psychiatria Polska, vol. 49, no. 4, pp. 779–789, 2015. View at Publisher · View at Google Scholar
  • Fabio Guerriero, Emanuele Botarelli, Gianni Mele, Lorenzo Polo, Daniele Zoncu, Paolo Renati, Carmelo Sgarlata, Marco Rollone, Giovanni Ricevuti, Niccolo Maurizi, Matthew Francis, Mariangela Rondanelli, Simone Perna, Davide Guido, and Piero Mannu, “An innovative intervention for the treatment of cognitive impairment-Emisymmetric bilateral stimulation improves cognitive functions in Alzheimer's di,” Neuropsychiatric Disease And Treatment, vol. 11, pp. 2391–2404, 2015. View at Publisher · View at Google Scholar
  • Grant Rutherford, Brian Lithgow, and Zahra Moussavi, “Short and long-term effects of rTMS treatment on Alzheimer's disease at different stages: A pilot study,” Journal of Experimental Neuroscience, vol. 2015, no. 9, pp. 43–51, 2015. View at Publisher · View at Google Scholar
  • Hatem Bouladour, Eloi Magnin, Magali Nicolier, Elfried Dariel, Géraldine Sylvestre, Julie Monnin, Gilles Chopard, Matthieu Bereau, Pierre Vandel, Emmanuel Haffen, Louis Berthet, and Sabrina Ferreira, “Left Prefrontal Repetitive Transcranial Magnetic Stimulation in a Logopenic Variant of Primary Progressive Aphasia: A Case Report,” European Neurology, vol. 76, no. 1-2, pp. 12–18, 2016. View at Publisher · View at Google Scholar
  • Yu Tian Wang, and Steven A. Connor, “A Place at the Table: LTD as a Mediator of Memory Genesis,” Neuroscientist, vol. 22, no. 4, pp. 359–371, 2016. View at Publisher · View at Google Scholar
  • Keren Avirame, Jimmy Stehberg, and Doron Todder, “Benefits of Deep Transcranial Magnetic Stimulation in Alzheimer Disease Case Series,” Journal Of Ect, vol. 32, no. 2, pp. 127–133, 2016. View at Publisher · View at Google Scholar
  • Martin Bystad, Ole Gronli, Ingrid Daae Rasmussen, Nina Gundersen, Lene Nordvang, Henrik Wang-Iversen, and Per M. Aslaksen, “Transcranial direct current stimulation as a memory enhancer in patients with Alzheimer's disease: a randomized, placebo-controlled trial,” Alzheimers Research & Therapy, vol. 8, 2016. View at Publisher · View at Google Scholar
  • Sanjeev Kumar, Benoit H. Mulsant, Angela Y. Liu, Daniel M. Blumberger, Zafiris J. Daskalakis, and Tarek K. Rajji, “A Systematic Review of Cognitive Effects of Electroconvulsive Therapy in Late-Life Depression,” The American Journal of Geriatric Psychiatry, 2016. View at Publisher · View at Google Scholar
  • Maria Vittoria Podda, Sara Cocco, Alessia Mastrodonato, Salvatore Fusco, Lucia Leone, Saviana Antonella Barbati, Claudia Colussi, Cristian Ripoli, and Claudio Grassi, “Anodal transcranial direct current stimulation boosts synaptic plasticity and memory in mice via epigenetic regulation of Bdnf expression,” Scientific Reports, vol. 6, 2016. View at Publisher · View at Google Scholar
  • Willem de Haan, Elisabeth C. W. van Straaten, Alida A. Gouw, and Cornelis J. Stam, “Altering neuronal excitability to preserve network connectivity in a computational model of Alzheimer's disease,” PLOS Computational Biology, vol. 13, no. 9, pp. e1005707, 2017. View at Publisher · View at Google Scholar
  • Haichao Zhao, Lei Qiao, Dongqiong Fan, Shuyue Zhang, Ofir Turel, Yonghui Li, Jun Li, Gui Xue, Antao Chen, and Qinghua He, “Modulation of Brain Activity with Noninvasive Transcranial Direct Current Stimulation (tDCS): Clinical Applications and Safety Concerns,” Frontiers in Psychology, vol. 8, 2017. View at Publisher · View at Google Scholar
  • Roey Baror, Emiliano Santarnecchi, Alvaro Pascual-Leone, Irene Gonsalvez, and Peter Fried, “Therapeutic noninvasive brain stimulation in Alzheimer’s disease,” Current Alzheimer Research, vol. 14, no. 4, pp. 362–376, 2017. View at Publisher · View at Google Scholar
  • Sherrard, Nouhaud, and Belmin, “Repetitive transcranial magnetic stimulation: A potential therapy for cognitive disorders?,” Revue de Medecine Interne, vol. 38, no. 3, pp. 188–194, 2017. View at Publisher · View at Google Scholar
  • Joshua Hendrikse, Murat Yücel, Aaron Kandola, James Coxon, and Nigel Rogasch, “Combining aerobic exercise and repetitive transcranial magnetic stimulation to improve brain function in health and disease,” Neuroscience and Biobehavioral Reviews, vol. 83, pp. 11–20, 2017. View at Publisher · View at Google Scholar
  • Filipe B. Rodrigues, André M. Travessa, Tiago A. Mestre, and Joaquim J. Ferreira, “Fifteen years of clinical trials in Huntington's disease: A very low clinical drug development success rate,” Journal of Huntington's Disease, vol. 6, no. 2, pp. 157–163, 2017. View at Publisher · View at Google Scholar
  • Erik Daniel Morelos Santana, Orely Osorio Rojas, Ruth Alcalá Lozano, and Jorge Julio González Olvera, “An overview of repetitive transcranial magnetic stimulation (rTMS) in Alzheimer's disease,” Salud Mental, vol. 40, no. 4, pp. 171–178, 2017. View at Publisher · View at Google Scholar
  • Mo Li, Ji-hui Lyu, Yi Zhang, Mao-long Gao, Ya-nan Gao, and Meng-nan Cui, “Efficacy and safety of infra-low-frequency transcranial magnetic stimulation in Alzheimer's disease patients with behavioral and psychological symptoms of dementia: study protocol for a randomized parallel-design controlled trial,” Asia Pacific Journal of Clinical Trials: Nervous System Diseases, vol. 2, no. 3, pp. 99, 2017. View at Publisher · View at Google Scholar
  • Jing Zhang, Jia Liu, Jie Li, Canfei Zhang, and Miao Qu, “Non-invasive brain stimulation for improving cognitive function in people with dementia and mild cognitive impairment,” Cochrane Database of Systematic Reviews, vol. 2018, no. 7, 2018. View at Publisher · View at Google Scholar
  • Yi-Cong Lin, and Yu-Ping Wang, “Status of noninvasive brain stimulation in the therapy of Alzheimer's disease,” Chinese Medical Journal, vol. 131, no. 24, pp. 2899–2903, 2018. View at Publisher · View at Google Scholar
  • Bin Shi, Li-zhuang Yang, Ying Liu, and Xiaochu Zhang, “Neural mechanism by which transcranial direct current stimulation reduces cigarette cravings: study protocol for a randomized controlled crossover trial,” Asia Pacific Journal of Clinical Trials: Nervous System Diseases, vol. 3, no. 1, pp. 17, 2018. View at Publisher · View at Google Scholar
  • Eugen Kvašňák, and Richard Rokyta, “Brain stimulation methods for pain treatment,” General Physiology and Biophysics, vol. 37, no. 5, pp. 477–494, 2018. View at Publisher · View at Google Scholar
  • Blake J. Lawrence, Natalie Gasson, Andrew R. Johnson, Leon Booth, and Andrea M. Loftus, “Cognitive Training and Transcranial Direct Current Stimulation for Mild Cognitive Impairment in Parkinson’s Disease: A Randomized Controlled Trial,” Parkinson's Disease, vol. 2018, pp. 1–12, 2018. View at Publisher · View at Google Scholar
  • Min Wu, Yamei Yu, Lunjie Luo, Yuehao Wu, Jian Gao, Xiangming Ye, and Benyan Luo, “Efficiency of Repetitive Transcranial Direct Current Stimulation of the Dorsolateral Prefrontal Cortex in Disorders of Consciousness: A Randomized Sham-Controlled Study,” Neural Plasticity, vol. 2019, pp. 1–11, 2019. View at Publisher · View at Google Scholar