International Journal of Alzheimer’s Disease

Novel Therapeutics in Alzheimer's Disease


Publishing date
01 Feb 2012
Status
Published
Submission deadline
01 Aug 2011

Lead Editor

1Banner Sun Health Research Institute, 10515 W. Santa Fe Dr, Sun City, AZ 85351, USA

2Memory Disorders Clinic, University of Rochester School of Medicine and Dentistry, 435 East Henrietta Road, Rochester, NY 14620, USA

3Alzheimer's Disease Center/Clinical Trials, 114 Whitwell St, Quincy, MA 02169, USA

4Department of Pharmacology and Therapeutics, Faculty of Medicine and Health Sciences, UAE University, Al Ain, UAE


Novel Therapeutics in Alzheimer's Disease

Description

The cholinesterase inhibitors (ChEIs) and memantine have become established as first steps in changing Alzheimer's disease (AD) from a disease for which there was no effective pharmacotherapy to a disease for which there is treatment. These agents provide detectable symptomatic improvement and have a modest impact on the progression of the disease from mild cognitive impairment (MCI) to disabling dementia and death. Nonetheless, the therapeutic limitations of the currently approved drugs, as well as the steadily increasing prevalence of the disease, have led to increased basic and clinical research aimed at developing better medications for the treatment of AD. Several drugs with widely differing targets are currently in development, some discovered serendipitously, some designed rationally based on evolving knowledge of the pathophysiology of AD, and some identified from epidemiologic research. To date, however, no novel agent has successfully cleared the gauntlet of all phases of the clinical development process. Much focus has been on amyloid-based approaches in recent years. Nevertheless, given the complexity of the disease, other therapeutic targets are being considered and developed.

We invite investigators to contribute original research articles as well as review articles that will stimulate the continuing efforts to describe and develop innovative and novel therapeutics for AD. We are particularly interested in articles describing the new and emerging treatments and targets for AD. Potential topics include, but are not limited to:

  • Beta secretase inhibitors
  • Gamma secretase inhibitors
  • Tangle and tau-based approaches
  • Novel anti-inflammatories
  • Amyloid clearance enhancers
  • Aggregation inhibitors
  • Gene therapies
  • Neurotransmitter-based approaches
  • Novel acetylcholinesterase inhibitors
  • Immunotherapies
  • sRAGE antagonists

Before submission authors should carefully read over the journal's Author Guidelines, which are located at http://www.hindawi.com/journals/ijad/guidelines/. Prospective authors should submit an electronic copy of their complete manuscript through the journal Manuscript Tracking System at http://mts.hindawi.com/ according to the following timetable:


Articles

  • Special Issue
  • - Volume 2012
  • - Article ID 207969
  • - Editorial

Novel Therapeutics in Alzheimer's Disease

Marwan Sabbagh | Anton P. Porsteinsson | ... | Abdu Adem
  • Special Issue
  • - Volume 2012
  • - Article ID 381974
  • - Research Article

Centella asiatica Extract Improves Behavioral Deficits in a Mouse Model of Alzheimer's Disease: Investigation of a Possible Mechanism of Action

Amala Soumyanath | Yong-Ping Zhong | ... | Joseph F. Quinn
  • Special Issue
  • - Volume 2012
  • - Article ID 947147
  • - Research Article

Silencing of Amyloid Precursor Protein Expression Using a New Engineered Delta Ribozyme

Manel Ben Aissa | Marie-Claude April | ... | Georges Levesque
  • Special Issue
  • - Volume 2012
  • - Article ID 109324
  • - Research Article

Simvastatin Blocks Blood-Brain Barrier Disruptions Induced by Elevated Cholesterol Both In Vivo and In Vitro

Xijuan Jiang | Maojuan Guo | ... | Yingchang Fan
  • Special Issue
  • - Volume 2012
  • - Article ID 628070
  • - Review Article

Targeting Beta Amyloid: A Clinical Review of Immunotherapeutic Approaches in Alzheimer's Disease

Kasia Lobello | J. Michael Ryan | ... | Ronald Black
  • Special Issue
  • - Volume 2012
  • - Article ID 594137
  • - Review Article

Leptin: A Novel Therapeutic Target in Alzheimer's Disease?

Dayne Beccano-Kelly | Jenni Harvey
  • Special Issue
  • - Volume 2012
  • - Article ID 728983
  • - Research Article

New Acetylcholinesterase Inhibitors for Alzheimer's Disease

Mona Mehta | Abdu Adem | Marwan Sabbagh
  • Special Issue
  • - Volume 2012
  • - Article ID 707468
  • - Review Article

Broader Considerations of Higher Doses of Donepezil in the Treatment of Mild, Moderate, and Severe Alzheimer's Disease

Camryn Berk | Marwan Sabbagh
  • Special Issue
  • - Volume 2012
  • - Article ID 687909
  • - Review Article

Effect of Transcranial Brain Stimulation for the Treatment of Alzheimer Disease: A Review

Raffaele Nardone | Jürgen Bergmann | ... | Stefan Golaszewski
International Journal of Alzheimer’s Disease
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