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International Journal of Alzheimer’s Disease
Volume 2012, Article ID 728983, 8 pages
http://dx.doi.org/10.1155/2012/728983
Research Article

New Acetylcholinesterase Inhibitors for Alzheimer's Disease

1The Cleo Roberts Center for Clinical Research, Banner Sun Health Research Institute, 10515 W Santa Fe Dr, Sun City, AZ 85351, USA
2Department of Pharmacology and Therapeutics, United Arab Emirates University, Al Ain, UAE

Received 31 July 2011; Revised 6 November 2011; Accepted 7 November 2011

Academic Editor: Anton P. Porsteinsson

Copyright © 2012 Mona Mehta et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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  • Jessica M. Curtis, Wendy S. Hahn, Eric K. Long, Joel S. Burrill, Edgar A. Arriaga, and David A. Bernlohr, “Protein carbonylation and metabolic control systems,” Trends in Endocrinology and Metabolism, vol. 23, no. 8, pp. 399–406, 2012. View at Publisher · View at Google Scholar
  • Malte Gersch, Johannes Kreuzer, and Stephan A. Sieber, “Electrophilic natural products and their biological targets,” Natural Product Reports, vol. 29, no. 6, pp. 659–682, 2012. View at Publisher · View at Google Scholar
  • Jonah Cheung, Michael J. Rudolph, Fiana Burshteyn, Michael S. Cassidy, Ebony N. Gary, James Love, Matthew C. Franklin, and Jude J. Height, “Structures of Human Acetylcholinesterase in Complex with Pharmacologically Important Ligands,” Journal Of Medicinal Chemistry, vol. 55, no. 22, pp. 10282–10286, 2012. View at Publisher · View at Google Scholar
  • Sabine Pompeia, Juliana Ramos Gouveia, and José Carlos Fernandes Galduróz, “Acute mood effect of donepezil in young, healthy volunteers,” Human Psychopharmacology: Clinical and Experimental, 2013. View at Publisher · View at Google Scholar
  • Dongli Liao, Jian Chen, Huipeng Zhou, Yan Wang, Yongxin Li, and Cong Yu, “In Situ Formation of Metal Coordination Polymer: A Strategy for Fluorescence Turn-On Assay of Acetylcholinesterase Activity and Inhibitor Screening,” Analytical Chemistry, vol. 85, no. 5, pp. 2667–2672, 2013. View at Publisher · View at Google Scholar
  • Jill R. Turner, Allison Gold, Robert Schnoll, and Julie A. Blendy, “Translational research in nicotine dependence,” Cold Spring Harbor Perspectives in Medicine, vol. 3, no. 3, 2013. View at Publisher · View at Google Scholar
  • Xm Qiang Xiaoming, W Yuan Wen, Zp Sang Zhipei, and Y Deng Yong, “Synthesis and Biological Evaluation of Genistein Carbamate Derivatives,” Chinese Journal of Organic Chemistry, vol. 33, no. 3, pp. 621–629, 2013. View at Publisher · View at Google Scholar
  • Wei-Na Han, Christian Hölscher, Li Yuan, Wei Yang, Xiao-Hui Wang, Mei-Na Wu, and Jin-Shun Qi, “Liraglutide protects against amyloid-β protein-induced impairment of spatial learning and memory in rats,” Neurobiology of Aging, vol. 34, no. 2, pp. 576–588, 2013. View at Publisher · View at Google Scholar
  • Luísa Custódio, João Patarra, Fernando Alberício, Nuno Rosa Neng, José Manuel Florêncio Nogueira, and Anabela Romano, “Extracts from Quercus sp. acorns exhibit in vitro neuroprotective features through inhibition of cholinesterase and protection of the human dopaminergic cell line SH-SY5Y from hydrogen peroxide-induced cytotoxicity,” Industrial Crops and Products, vol. 45, pp. 114–120, 2013. View at Publisher · View at Google Scholar
  • Wen Yuan, Zhipei Shang, Xiaoming Qiang, Zhenghuai Tan, and Yong Deng, “Synthesis of pterostilbene and resveratrol carbamate derivatives as potential dual cholinesterase inhibitors and neuroprotective agents,” Research on Chemical Intermediates, 2013. View at Publisher · View at Google Scholar
  • S. K. Singh, D. N. Mishra, and Kalpana Nagpal, “Optimization of brain targeted chitosan nanoparticles of Rivastigmine for improved efficacy and safety,” International Journal Of Biological Macromolecules, vol. 59, pp. 72–83, 2013. View at Publisher · View at Google Scholar
  • Nichole M. Neugebauer, Yann S. Mineur, Emily B. Einstein, Maria B. Lopez, Tristan D. McClure-Begley, and Marina R. Picciotto, “Morphine dependence and withdrawal induced changes in cholinergic signaling,” Pharmacology Biochemistry And Behavior, vol. 109, pp. 77–83, 2013. View at Publisher · View at Google Scholar
  • Ilkay Erdogan Orhan, “Nature: A Substantial Source of Auspicious Substances with Acetylcholinesterase Inhibitory Action,” Current Neuropharmacology, vol. 11, no. 4, pp. 379–387, 2013. View at Publisher · View at Google Scholar
  • Wolfgang Froestl, Andreas Muhs, and Andrea Pfeifer, “Cognitive enhancers (nootropics). Part 2: Drugs interacting with enzymes,” Journal of Alzheimer's Disease, vol. 33, no. 3, pp. 547–658, 2013. View at Publisher · View at Google Scholar
  • Seyed Mohsen Mortazavian, Heydar Parsaee, Seyed Hadi Mousavi, Zahra Tayarani-Najaran, Ahmad Ghorbani, and Hamid Reza Sadeghnia, “Acetylcholinesterase Inhibitors Promote Angiogenesis in Chick Chorioallantoic Membrane and Inhibit Apoptosis of Endothelial Cells,” International Journal of Alzheimer's Disease, vol. 2013, pp. 1–7, 2013. View at Publisher · View at Google Scholar
  • Todd J. Eckroat, Keith D. Green, Abdelrahman S. Mayhoub, Mi Hee Lim, Akiko Kochi, and Sylvie Garneau-Tsodikova, “A novel hybrid of 6-chlorotacrine and metal-amyloid-β modulator for inhibition of acetylcholinesterase and metal-induced amyloid-β aggregation,” Chemical Science, vol. 4, no. 11, pp. 4137–4145, 2013. View at Publisher · View at Google Scholar
  • Maha M. Soltan, Usama M. Hegazy, Esameldin E. Elgorashi, Shereen K. Ali, Ahmed A. Hussein, Ahmed R. Hamed, and Ibrahim A. El-Garf, “In-vitro evaluation of selected Egyptian traditional herbal medicines for treatment of alzheimer disease,” Bmc Complementary And Alternative Medicine, vol. 13, 2013. View at Publisher · View at Google Scholar
  • Marie Vandeput, Cobra Parsajoo, Jérôme Vanheuverzwijn, Stéphanie Patris, Yavuz Yardim, Alexandre le Jeune, Ahmad Sarakbi, Dominique Mertens, and Jean-Michel Kauffmann, “Flow-through enzyme immobilized amperometric detector for the rapid screening of acetylcholinesterase inhibitors by flow injection analysis,” Journal of Pharmaceutical and Biomedical Analysis, 2014. View at Publisher · View at Google Scholar
  • Hayrettin Ozan Gulcan, Serdar Unlu, İlker Esiringu, Tugba Ercetin, Yasemin Sahin, Demet Oz, and Mustafa Fethi Sahin, “Design, synthesis and biological evaluation of novel 6H-benzo[c]chromen-6-one, and 7,8,9,10-tetrahydro-benzo[c]chromen-6-one derivatives as potential cholinesterase inhibitors,” Bioorganic & Medicinal Chemistry, 2014. View at Publisher · View at Google Scholar
  • Alexey Yu. Sukhorukov, Anilkumar C. Nirvanappa, Jagadish Swamy, Sema L. Ioffe, Shivananju Nanjunda Swamy, Basappa Basappa, and Kanchugarakoppal S. Rangappa, “Synthesis and characterization of novel 1,2-oxazine-based small molecules that targets acetylcholinesterase,” Bioorganic & Medicinal Chemistry Letters, vol. 24, no. 15, pp. 3618–3621, 2014. View at Publisher · View at Google Scholar
  • Gudrun Hefner, Anne Brueckner, Christoph Hiemke, and Andreas Fellgiebel, “Therapeutic drug monitoring for patients with alzheimer dementia to improve treatment with donepezil,” Therapeutic Drug Monitoring, vol. 37, no. 3, pp. 353–361, 2014. View at Publisher · View at Google Scholar
  • Ayokunle Olubode Ademosun, and Ganiyu Oboh, “Anticholinesterase and antioxidative properties of water-extractable phytochemicals from some citrus peels,” Journal of Basic and Clinical Physiology and Pharmacology, vol. 25, no. 2, pp. 199–204, 2014. View at Publisher · View at Google Scholar
  • Jin Bae Weon, Bohyoung Lee, Bo-Ra Yun, Jiwoo Lee, Jin Yeul Ma, and Choong Je Ma, “Neuroprotective and cognitive enhancing activity of the fermented Bozhougyiqi-Tang,” Pharmacognosy Magazine, vol. 10, no. 38, pp. 249–255, 2014. View at Publisher · View at Google Scholar
  • Tiago Silva, Joana Reis, José Teixeira, and Fernanda Borges, “Alzheimer's disease, enzyme targets and drug discovery struggles: from natural products to drug prototypes,” Ageing Research Reviews, 2014. View at Publisher · View at Google Scholar
  • Marc Pudlo, Vincent Luzet, Lhassane Ismaili, Isabelle Tomassoli, Anne Iutzeler, and Bernard Refouvelet, “Quinolone-benzylpiperidine derivatives as novel acetylcholinesterase inhibitor and antioxidant hybrids for Alzheimer Disease,” Bioorganic & Medicinal Chemistry, vol. 22, no. 8, pp. 2496–2507, 2014. View at Publisher · View at Google Scholar
  • Yingling Wei, Ai-Yun Peng, Bo Wang, Lin Ma, Guoping Peng, Yidan Du, and Jingming Tang, “Synthesis and biological evaluation of phosphorylated flavonoids as potent and selective inhibitors of cholesterol esterase,” European Journal of Medicinal Chemistry, vol. 74, pp. 751–758, 2014. View at Publisher · View at Google Scholar
  • Shuai Qian, Lisi He, Marvin Mak, Yifan Han, Chun-Yu Ho, and Zhong Zuo, “Synthesis, biological activity, and biopharmaceutical characterization of tacrine dimers as acetylcholinesterase inhibitors,” International Journal Of Pharmaceutics, vol. 477, no. 1-2, pp. 442–453, 2014. View at Publisher · View at Google Scholar
  • Diego A. Cifuente, Mariana G. Vallejo, Maria G. Ortega, José L. Cabrera, Víctor S. Martín, Carlos E. Tonn, Alicia M. Agnese, and Carlos E. Ardanaz, “ Mass spectrometry studies of lycodine-type Lycopodium alkaloids: sauroxine and N -demethylsauroxine ,” Rapid Communications in Mass Spectrometry, vol. 28, no. 24, pp. 2690–2694, 2014. View at Publisher · View at Google Scholar
  • Maya Mathew, and Sarada Subramanian, “In Vitro Screening for Anti-Cholinesterase and Antioxidant Activity of Methanolic Extracts of Ayurvedic Medicinal Plants Used for Cognitive Disorders,” Plos One, vol. 9, no. 1, 2014. View at Publisher · View at Google Scholar
  • Katselou, Matralis, and Kourounakis, “Multi-target drug design approaches for multifactorial diseases: From neurodegenerative to cardiovascular applications,” Current Medicinal Chemistry, vol. 21, no. 24, pp. 2743–2787, 2014. View at Publisher · View at Google Scholar
  • Raju Dash, Talha Bin Emran, Mir Muhammad Nasir Uddin, Ashekul Islam, and Md Junaid, “Molecular docking of fisetin with AD associated AChE, ABAD and BACE1 proteins.,” Bioinformation, vol. 10, no. 9, pp. 562–8, 2014. View at Publisher · View at Google Scholar
  • Adel Mohammad Abuzenadah, Shams Tabrez, Nasimudeen R. Jabir, Mohammad A. Kamal, Siew Hua Gan, Mohammed Nabil Alama, and Saleh S. Baeesa, “Alzheimer's and type 2 diabetes treatment via common enzyme targeting,” CNS and Neurological Disorders - Drug Targets, vol. 13, no. 2, pp. 299–304, 2014. View at Publisher · View at Google Scholar
  • Aftab Alam, Sibhghatulla Shaikh, Mohammad A. Ansari, Shahnawaz Shakil, Syed M.D. Rizvi, Syed S. Ahmad, Mohammad Imran, Mohammad Haneef, Adel M. Abuzenadah, Mohammad A. Kamal, and Shazi Shakil, “Molecular interaction of human brain acetylcholinesterase with a natural inhibitor Huperzine-B: An enzoinformatics approach,” CNS and Neurological Disorders - Drug Targets, vol. 13, no. 3, pp. 487–490, 2014. View at Publisher · View at Google Scholar
  • Shahnawaz Shakil, Mohammad A. Kamal, Anupriya Verma, Divya Singh, Mohmmad H. Siddiqui, Sibhghatulla Shaikh, Shams Tabrez, Saimeen Siddiqui, Syed S. Ahmad, Syed M.D. Rizvi, Shazi Shakil, and Deboshree Biswas, “Current acetylcholinesterase-inhibitors: A neuroinformatics perspective,” CNS and Neurological Disorders - Drug Targets, vol. 13, no. 3, pp. 391–401, 2014. View at Publisher · View at Google Scholar
  • Mauricio Alcolea-Palafox, Paloma Posada-Moreno, Ismael Ortuño-Soriano, José L. Pacheco-del-Cerro, Carmen Martínez-Rincón, Dolores Rodríguez-Martínez, and Lara Pacheco-Cuevas, “Research Strategies Developed for the Treatment of Alzheimer’s Disease. Reversible and Pseudo-Irreversible Inhibitors of Acetylcholinesterase: Structure-Activity Relationships and Drug Design,” Drug Design and Discovery in Alzheimer's Disease, pp. 426–477, 2014. View at Publisher · View at Google Scholar
  • Lucie Cahlíková, Kateřina Macáková, Nina Benešová, Jakub Chlebek, Anna Hošťálková, and Lubomír Opletal, “Natural Compounds (Small Molecules) as Potential and Real Drugs of Alzheimer's Disease,” vol. 42, pp. 153–194, 2014. View at Publisher · View at Google Scholar
  • Lucie Cahlíková, Kateřina Macáková, Nina Benešová, Jakub Chlebek, Anna Hošťálková, and Lubomír Opletal, “Natural compounds (Small molecules) as potential and real drugs of Alzheimer's disease: A critical review,” Studies in Natural Products Chemistry, vol. 42, no. 1, pp. 153–194, 2014. View at Publisher · View at Google Scholar
  • Marian Valko, Klaudia Jomova, Christopher J. Rhodes, Kamil Kuča, and Kamil Musílek, “Redox- and non-redox-metal-induced formation of free radicals and their role in human disease,” Archives of Toxicology, 2015. View at Publisher · View at Google Scholar
  • Jing Li, Wei Zhou, Xiaoli Wu, and Kin Tam, “Chemical and physical approaches for the treatment of Alzheimer's disease,” ADMET and DMPK, vol. 3, no. 3, pp. 216–234, 2015. View at Publisher · View at Google Scholar
  • Khorshid, Fatma Hassan, A. M. Mona Abd El-Gawad, and Enab, “Effect of some plants and pesticides on acetylcholinesterase,” American Journal of Food Technology, vol. 10, no. 3, pp. 93–99, 2015. View at Publisher · View at Google Scholar
  • Damijan Knez, Boris Brus, Nicolas Coquelle, Izidor Sosič, Xavier Brazzolotto, Stanislav Gobec, Roman Šink, Janez Mravljak, and Jacques-Philippe Colletier, “Structure-based development of nitroxoline derivatives as potential multifunctional anti-Alzheimer agents,” Bioorganic and Medicinal Chemistry, vol. 23, no. 15, pp. 4442–4452, 2015. View at Publisher · View at Google Scholar
  • Yaghoub Pourshojaei, Ali Gouranourimi, Shohre Hekmat, Ali Asadipour, Samira Rahmani-Nezhad, Alireza Moradi, Hamid Nadri, Farshad Homayouni Moghadam, Saeed Emami, Alireza Foroumadi, and Abbas Shafiee, “Design, synthesis and anticholinesterase activity of novel benzylidenechroman-4-ones bearing cyclic amine side chain,” European Journal Of Medicinal Chemistry, vol. 96, pp. 181–189, 2015. View at Publisher · View at Google Scholar
  • Martin Nimczick, and Michael Decker, “New Approaches in the Design and Development of Cannabinoid Receptor Ligands: Multifunctional and Bivalent Compounds,” ChemMedChem, vol. 10, no. 5, pp. 773–786, 2015. View at Publisher · View at Google Scholar
  • Saeed Sadigh-Eteghad, Mahnaz Talebi, Javad Mahmoudi, Shirin Babri, and Dariush Shanehbandi, “Selective activation of alpha 7 nicotinic acetylcholine receptor by pha-543613 improves beta-amyloid 25–35 mediated cognitive deficits in mice,” Neuroscience, 2015. View at Publisher · View at Google Scholar
  • Saeed Sadigh-Eteghad, Alireza Majdi, Mahnaz Talebi, Javad Mahmoudi, and Shirin Babri, “Regulation of nicotinic acetylcholine receptors in Alzheimer's disease: Apossible role of chaperones,” European Journal of Pharmacology, 2015. View at Publisher · View at Google Scholar
  • Dong-Young Choi, and Hyukjae Choi, “Natural products from marine organisms with neuroprotective activity in the experimental models of Alzheimer's disease, Parkinson's disease and ischem,” Archives Of Pharmacal Research, vol. 38, no. 2, pp. 139–170, 2015. View at Publisher · View at Google Scholar
  • Jan Misik, Jan Korabecny, Eugenie Nepovimova, Pavla Cabelova, and Jiri Kassa, “The effects of novel 7-MEOTA-donepezil like hybrids and N-alkylated tacrine analogues in the treatment of quinuclidinyl benzilate-induced behavioural deficits in rats performing the multiple T-maze test,” Biomedical Papers, 2015. View at Publisher · View at Google Scholar
  • Melissa D'Ascenzio, Stefano Alcaro, Matilde Yáñez, Simone Carradori, Paola Chimenti, Maria Concetta Gidaro, Celeste De Monte, Daniela De Vita, Arianna Granese, Luigi Scipione, Roberto Di Santo, and Giosuè Costa, “(Thiazol-2-yl)hydrazone derivatives from acetylpyridines as dual inhibitors of MAO and AChE: Synthesis, biological evaluation and molecular modeling studies,” Journal of Enzyme Inhibition and Medicinal Chemistry, vol. 30, no. 6, pp. 908–919, 2015. View at Publisher · View at Google Scholar
  • Zhengping Zhang, Rong Chen, Wenji An, Chunmei Wang, Gaoyong Liao, Xiaoliang Dong, Aijing Bi, Zhimin Yin, and Lan Luo, “A novel acetylcholinesterase inhibitor and calcium channel blocker SCR-1693 improves Aβ25–35-impaired mouse cognitive function,” Psychopharmacology, 2015. View at Publisher · View at Google Scholar
  • Gyeo-Re Han, and Chang-Hyun Jang, “Liquid crystal sensor for the detection of acetylcholine using acetylcholinesterase immobilized on a nanostructured polymeric surface,” Colloid And Polymer Science, vol. 293, no. 10, pp. 2771–2779, 2015. View at Publisher · View at Google Scholar
  • Alexandra Gaspar, Nuno Milhazes, Lourdes Santana, Eugenio Uriarte, Fernanda Borges, and Maria Joao Matos, “Oxidative Stress and Neurodegenerative Diseases: Looking for a Therapeutic Solution Inspired on Benzopyran Chemistry,” Current Topics In Medicinal Chemistry, vol. 15, no. 5, pp. 432–445, 2015. View at Publisher · View at Google Scholar
  • Bruno Fonseca-Santos, Maria Palmira Daflon Gremiao, and Marlus Chorilli, “Nanotechnology-based drug delivery systems for the treatment of Alzheimer's disease,” International Journal Of Nanomedicine, vol. 10, 2015. View at Publisher · View at Google Scholar
  • Shreesh Raj Sammi, Shalini Trivedi, Srikanta Kumar Rath, Abhishek Nagar, Sudeep Tandon, Alok Kalra, and Rakesh Pandey, “1-Methyl-4-propan-2-ylbenzene from Thymus vulgaris Attenuates Cholinergic Dysfunction,” Molecular Neurobiology, 2016. View at Publisher · View at Google Scholar
  • Liao-Bin Dong, Xing-De Wu, Xin Shi, Zhi-Jun Zhang, Jing Yang, and Qin-Shi Zhao, “ Phleghenrines A–D and Neophleghenrine A, Bioactive and Structurally Rigid Lycopodium Alkaloids from Phlegmariurus henryi ,” Organic Letters, 2016. View at Publisher · View at Google Scholar
  • Patrícia Bacalhau, Amor A. San Juan, Anthony J. Burke, Albertino Goth, A. Teresa Caldeira, and Rosário Martins, “Insights into (S)-rivastigmine inhibition of butyrylcholinesterase (BuChE): Molecular docking and saturation transfer difference NMR (STD-NMR),” Bioorganic Chemistry, vol. 67, pp. 105–109, 2016. View at Publisher · View at Google Scholar
  • Jane Totobenazara, Patrícia Bacalhau, Amor A. San Juan, Carolina S. Marques, Luís Fernandes, Albertino Goth, A. Teresa Caldeira, Rosário Martins, and Anthony J. Burke, “Design, Synthesis and Bioassays of 3-Substituted-3-Hydroxyoxindoles for Cholinesterase Inhibition,” ChemistrySelect, vol. 1, no. 13, pp. 3580–3588, 2016. View at Publisher · View at Google Scholar
  • Ming Shiuan Soh, and Gursimran Chandhok, “Presynaptic deficits at neuromuscular junctions: A specific cause and potential target of axonal neuropathy in type 2 Charcot–Marie–Tooth disease,” Journal of Neuroscience, vol. 36, no. 31, pp. 8067–8069, 2016. View at Publisher · View at Google Scholar
  • Arun Bahadur Gurung, Kripamoy Aguan, Sivaprasad Mitra, and Atanu Bhattacharjee, “Identification of molecular descriptors for design of novel Isoalloxazine derivatives as potential Acetylcholinesterase inhibitors against Alzheimer’s disease,” Journal of Biomolecular Structure and Dynamics, pp. 1–14, 2016. View at Publisher · View at Google Scholar
  • Wannee Jiraungkoorskul, “Review of neuro-nutrition used as anti-Alzheimer plant, spinach Spinacia oleracea,” Pharmacognosy Reviews, vol. 10, no. 20, pp. 105–108, 2016. View at Publisher · View at Google Scholar
  • Masuri Kama Kamaruddin Shah, Hasnah Mohd Sirat, and Shajarahtunnur Jamil, “Cholinesterase inhibitors from heartwood of artocarpus fulvicortex F. M. Jarret (Moraceae),” Jurnal Teknologi, vol. 78, no. 6, pp. 185–189, 2016. View at Publisher · View at Google Scholar
  • Cengiz Sarikurkcu, Mehmet Cemil Uren, Mehmet Sefa Kocak, Mustafa Cengiz, and Bektas Tepe, “Chemical composition, antioxidant, and enzyme inhibitory activities of the essential oils of three Phlomis species as well as their fatty acid compositions,” Food Science and Biotechnology, vol. 25, no. 3, pp. 687–693, 2016. View at Publisher · View at Google Scholar
  • Natarajan Suganthy, Dicson Sheeja Malar, and Kasi Pandima Devi, “Rhizophora mucronata attenuates beta-amyloid induced cognitive dysfunction, oxidative stress and cholinergic deficit in Alzheimer’s disease animal model,” Metabolic Brain Disease, 2016. View at Publisher · View at Google Scholar
  • Makhaeva, Boltneva, Serebryakova, Rudakova, Trofimova, Proshin, and Bachurin, “Synthesis and studies of biological activity of N-(4-tert-butylbenzyl)-N-(pyridin-3-ylmethyl)-2-aminothiazolines as potential multifunctional agents for treatment of neurodegenerative diseases,” Russian Chemical Bulletin, vol. 65, no. 5, pp. 1341–1345, 2016. View at Publisher · View at Google Scholar
  • Luana G. de Souza, Magdalena N. Rennó, and Jose D. Figueroa-Villar, “Coumarins as cholinesterase inhibitors: A review,” Chemico-Biological Interactions, 2016. View at Publisher · View at Google Scholar
  • Rabya Munawar, Nousheen Mushtaq, Sadia Arif, Ahsaan Ahmed, Shamim Akhtar, Sumaira Ansari, Sadia Meer, Zafar S. Saify, and Muhammad Arif, “Synthesis of 9-Aminoacridine Derivatives as Anti-Alzheimer Agents,” American Journal Of Alzheimers Disease And Other Dementias, vol. 31, no. 3, pp. 263–269, 2016. View at Publisher · View at Google Scholar
  • Claire Shoemake, and Sara Bonavia, “Design and optimisation of novel Huperzine A analogues capable of modulating the acetylcholinesterase receptor for the management of alzheimer’s disease,” Journal of Pharmacognosy and Phytotherapy, vol. 8, no. 5, pp. 99–108, 2016. View at Publisher · View at Google Scholar
  • Rosaliana Libro, Sabrina Giacoppo, Thangavelu Soundara Rajan, Placido Bramanti, and Emanuela Mazzon, “Natural Phytochemicals in the Treatment and Prevention of Dementia: An Overview,” Molecules, vol. 21, no. 4, pp. 518, 2016. View at Publisher · View at Google Scholar
  • Jee Hyun Yi, Hey Jin Park, Seungheon Lee, Ji Wook Jung, Byeong C. Kim, Young Choon Lee, Jong Hoon Ryu, and Dong Hyun Kim, “Cassia obtusifolia seed ameliorates amyloid β-induced synaptic dysfunction through anti-inflammatory and Akt/GSK-3β pathways,” Journal of Ethnopharmacology, vol. 178, pp. 50–57, 2016. View at Publisher · View at Google Scholar
  • Mullah Muhaiminul Islam, Arun Bahadur Gurung, Atanu Bhattacharjee, Kripamoy Aguan, and Sivaprasad Mitra, “Human serum albumin reduces the potency of acetylcholinesterase inhibitor based drugs for Alzheimer's disease,” Chemico-Biological Interactions, 2016. View at Publisher · View at Google Scholar
  • Ruchi Malik, Bhanwar Singh Choudhary, Shubham Srivastava, Pakhuri Mehta, and Manish Sharma, “Identification of novel acetylcholinesterase inhibitors through e-pharmacophore-based virtual screening and molecular dynamics simulations,” Journal of Biomolecular Structure and Dynamics, pp. 1–17, 2016. View at Publisher · View at Google Scholar
  • Ayokunle O. Ademosun, Ganiyu Oboh, Fatai Bello, and Peluola O. Ayeni, “Antioxidative Properties and Effect of Quercetin and Its Glycosylated Form (Rutin) on Acetylcholinesterase and Butyrylcholinesterase Activities,” Journal of Evidence-Based Complementary & Alternative Medicine, vol. 21, no. 4, pp. NP11–NP17, 2016. View at Publisher · View at Google Scholar
  • Rafael Carlos Lajmanovich, Andrés Maximiliano Attademo, Paola Mariela Peltzer, Celina María Junges, and Candela Soledad Martinuzzi, “ Acute toxicity of apple snail Pomacea canaliculata ’s eggs on Rhinella arenarum tadpoles ,” Toxin Reviews, pp. 1–7, 2016. View at Publisher · View at Google Scholar
  • Mullah Muhaiminul Islam, and Sivaprasad Mitra, “Cholinergic inhibitors replace thioflavin-T from acetylcholinesterase binding pocket: A potential fluorescence based molecular switch,” Chemical Physics Letters, 2016. View at Publisher · View at Google Scholar
  • Jan Misik, Jan Korabecny, Eugenie Nepovimova, Alzbeta Kracmarova, and Jiri Kassa, “Effects of novel tacrine-related cholinesterase inhibitors in the reversal of 3-quinuclidinyl benzilate-induced cognitive deficit in rats-Is there a potential for Alzheimer's disease treatment?,” Neuroscience Letters, vol. 612, pp. 261–268, 2016. View at Publisher · View at Google Scholar
  • N. Suganthy, and K. Pandima Devi, “In vitro antioxidant and anti-cholinesterase activities of Rhizophora mucronata,” Pharmaceutical Biology, vol. 54, no. 1, pp. 118–129, 2016. View at Publisher · View at Google Scholar
  • Khong Heng Yen, Wan Mohd Nuzul Hakimi Wan Salleh, Farediah Ahmad, and Razauden Mohamed Zulkifli, “Anticholinesterase and anti-inflammatory constituents from Beilschmiedia pulverulenta kosterm,” Natural Product Sciences, vol. 22, no. 4, pp. 225–230, 2016. View at Publisher · View at Google Scholar
  • Eric Siemers, Karen L. Sundell, Hong Liu-Seifert, and Karen Chilcott Holdridge, “Function and clinical meaningfulness of treatments for mild Alzheimer's disease,” Alzheimer's and Dementia: Diagnosis, Assessment and Disease Monitoring, vol. 2, pp. 105–112, 2016. View at Publisher · View at Google Scholar
  • Ruben Vardanyan, and Victor Hruby, “Cholinomimetics,” Synthesis of Best-Seller Drugs, pp. 215–225, 2016. View at Publisher · View at Google Scholar
  • Chong Zhang, Lindsay M. Lueptow, Han-Ting Zhang, James M. O’Donnell, and Ying Xu, “The Role of Phosphodiesterase-2 in Psychiatric and Neurodegenerative Disorders,” Phosphodiesterases: CNS Functions and Diseases, vol. 17, pp. 307–347, 2017. View at Publisher · View at Google Scholar
  • Shikha Lohan, Bhupinder Singh, Kaisar Raza, Mehta, Gurjit Kaur Bhatti, and Sumant Saini, “Anti-Alzheimer's potential of berberine using surface decorated multi-walled carbon nanotubes: A preclinical evidence,” International Journal of Pharmaceutics, vol. 530, no. 1-2, pp. 263–278, 2017. View at Publisher · View at Google Scholar
  • Abhinav Anand, Puneet Khurana, Jasneet Chawla, Neha Sharma, and Navneet Khurana, “Emerging treatments for the behavioral and psychological symptoms of dementia,” CNS Spectrums, vol. 23, no. 6, pp. 361–369, 2017. View at Publisher · View at Google Scholar
  • Mullah Muhaiminul Islam, Mostofa Ataur Rohman, Arun Bahadur Gurung, Atanu Bhattacharjee, Kripamoy Aguan, and Sivaprasad Mitra, “Correlation of cholinergic drug induced quenching of acetylcholinesterase bound thioflavin-T fluorescence with their inhibition activity,” Spectrochimica Acta Part A: Molecular and Biomolecular Spectroscopy, 2017. View at Publisher · View at Google Scholar
  • Taiwo Olayemi Elufioye, Joseph M Agbedahunsi, Efere M Obuotor, and Saburi A Adesanya, “Anticholinesterase constituents from the leaves of Spondias mombin L. (Anacardiaceae),” Biologics: Targets and Therapy, vol. 11, pp. 107–114, 2017. View at Publisher · View at Google Scholar
  • Fatma Gonca Kocanci, Buket Hamamcioglu, and Belma Aslim, “The anti-AChE and anti-proliferative Activities of Glaucium acutidentatum and Glaucium corniculatum Alkaloid Extracts,” Journal of Applied Pharmaceutical Science, vol. 7, no. 8, pp. 191–200, 2017. View at Publisher · View at Google Scholar
  • Rona Ramsay, and Keith Tipton, “Assessment of Enzyme Inhibition: A Review with Examples from the Development of Monoamine Oxidase and Cholinesterase Inhibitory Drugs,” Molecules, vol. 22, no. 7, pp. 1192, 2017. View at Publisher · View at Google Scholar
  • Joana Henriques, Pedro Luis Falé, Rita Pacheco, Maria Helena Florêncio, and Maria Luísa Serralheiro, “Phenolic compounds from Actinidia deliciosa leaves: Caco-2 permeability, enzyme inhibitory activity and cell protein profile studies,” Journal of King Saud University - Science, 2017. View at Publisher · View at Google Scholar
  • Zeynep Özdemir, Hayriye Yılmaz, Suat Sarı, Arzu Karakurt, Fatma Sezer Şenol, and Mehtap Uysal, “Design, synthesis, and molecular modeling of new 3(2H)-pyridazinone derivatives as acetylcholinesterase/butyrylcholinesterase inhibitors,” Medicinal Chemistry Research, 2017. View at Publisher · View at Google Scholar
  • Bilqees Sameem, Mina Saeedi, Mohammad Mahdavi, Hamid Nadri, Farshad Homayouni Moghadam, Najmeh Edraki, Muhammad Imran Khan, and Mohsen Amini, “Synthesis, docking study and neuroprotective effects of some novel pyrano[3,2- c ]chromene derivatives bearing morpholine/phenylpiperazine moiety,” Bioorganic & Medicinal Chemistry, 2017. View at Publisher · View at Google Scholar
  • Marcin Ozarowski, Przemyslaw L. Mikolajczak, Anna Piasecka, Radoslaw Kujawski, Joanna Bartkowiak-Wieczorek, Anna Bogacz, Michal Szulc, Ewa Kaminska, Malgorzata Kujawska, Agnieszka Gryszczynska, Piotr Kachlicki, Waldemar Buchwald, Andrzej Klejewski, and Agnieszka Seremak- Mrozikiewicz, “Effect of Salvia miltiorrhiza root extract on brain acetylcholinesterase and butyrylcholinesterase activities, their mRNA levels and memory evaluation in rats,” Physiology & Behavior, vol. 173, pp. 223–230, 2017. View at Publisher · View at Google Scholar
  • Nargis Sultana, Muhammad Sarfraz, Saba Tahir, Muhammad SafwanAkram, Abdul Sadiq, Umer Rashid, and Muhammad Ilyas Tariq, “Synthesis, Crystal structure determination, biological screening and docking studies of N 1 -substituted derivatives of 2,3-dihydroquinazolin-4( 1H )-one as inhibitors of cholinesterases,” Bioorganic Chemistry, 2017. View at Publisher · View at Google Scholar
  • Patrycja Michalska, Izaskun Buendia, Laura del Barrio, and Rafael León, “Novel multitarget hybrid compounds for the treatment of alzheimer’s disease,” Current Topics in Medicinal Chemistry, vol. 17, no. 9, pp. 1027–1043, 2017. View at Publisher · View at Google Scholar
  • Severina Pacifico, Simona Piccolella, Annamaria Lettieri, Paola Nocera, Flavia Bollino, and Michelina Catauro, “A metabolic profiling approach to an Italian sage leaf extract (SoA541) defines its antioxidant and anti-acetylcholinesterase properties,” Journal of Functional Foods, vol. 29, pp. 1–9, 2017. View at Publisher · View at Google Scholar
  • Seong Min Hong, Kyong Hee Soe, Taek Hwan Lee, In Sook Kim, Young Min Lee, and Beong Ou Lim, “ Cognitive Improving Effects by Highbush Blueberry ( Vaccinium crymbosum L.) Vinegar on Scopolamine-Induced Amnesia Mice Model ,” Journal of Agricultural and Food Chemistry, 2017. View at Publisher · View at Google Scholar
  • Jiwon Baek, Eun Bee Jung, Ki Sung Kang, Seulah Lee, Dahae Lee, Ji Yun Baek, Il Kyun Lee, Tae Su Jang, and Ki Hyun Kim, “In vitro assessment of selected Korean plants for antioxidant and antiacetylcholinesterase activities,” Pharmaceutical Biology, vol. 55, no. 1, pp. 2205–2210, 2017. View at Publisher · View at Google Scholar
  • Abhinav Anand, Albert Anosi Patience, Neha Sharma, and Navneet Khurana, “The present and future of pharmacotherapy of Alzheimer’s disease: a comprehensive review,” European Journal of Pharmacology, 2017. View at Publisher · View at Google Scholar
  • Muhammad Sarfraz, Nargis Sultana, Umer Rashid, Muhammad Safwan Akram, Abdul Sadiq, and Muhammad Ilyas Tariq, “Synthesis, biological evaluation and docking studies of 2,3-dihydroquinazolin-4(1H)-one derivatives as inhibitors of cholinesterases,” Bioorganic Chemistry, 2017. View at Publisher · View at Google Scholar
  • Mari Paz Serrano, Raquel Herrero-Labrador, Julia Serrano, Alejandro Romero, Abdelouahid Samadi, Ricardo Martínez-Murillo, Hunter S. Futch, Ana Patricia Fernandez, Mercedes Unzeta, and Jose Marco-Contelles, “The proof-of-concept of ASS234: Peripherally administered ASS234 enters the central nervous system and reduces pathology in a male mouse model of Alzheimer disease,” Journal of Psychiatry and Neuroscience, vol. 42, no. 1, pp. 59–69, 2017. View at Publisher · View at Google Scholar
  • Sravan Sreenivasmurthy, Jing-Yi Liu, Ju-Xian Song, Chuan-Bin Yang, Sandeep Malampati, Zi-Ying Wang, Ying-Yu Huang, and Min Li, “Neurogenic Traditional Chinese Medicine as a Promising Strategy for the Treatment of Alzheimer’s Disease,” International Journal of Molecular Sciences, vol. 18, no. 2, pp. 272, 2017. View at Publisher · View at Google Scholar
  • Zübeyde Erbayraktar, Görsev Yener, N. Nuray Ulusu, and Ahmet Evlice, “Effects of donepezil on liver and kidney functions for the treatment of Alzheimer's disease,” Journal of Integrative Neuroscience, vol. 16, no. 3, pp. 335–346, 2017. View at Publisher · View at Google Scholar
  • MohamedAsik Rajmohamed, Suganthy Natarajan, Premkumar Palanisamy, AkbarshaMohammad Abdulkader, and Archunan Govindaraju, “Antioxidant and cholinesterase inhibitory activities of ethyl acetate extract of Terminalia chebula: Cell-free In vitro and In silico studies,” Pharmacognosy Magazine, vol. 13, no. 51, pp. 437, 2017. View at Publisher · View at Google Scholar
  • Shraddha Sriraman, Sujata Roy, and Nanda Gopal Saha, “Interaction of curcumin with different target proteins of Alzheimer's disease: Docking and MD simulation studies,” International Journal of Computational Biology and Drug Design, vol. 10, no. 4, pp. 315–330, 2017. View at Publisher · View at Google Scholar
  • Adolfo Toledano, Arantxa Rodriguez-Casado, and Adolfo Toledano-Díaz, “Defective insulin signalling, mediated by inflammation, connects obesity to Alzheimer disease; relevant pharmacological therapies and preventive dietary interventions,” Current Alzheimer Research, vol. 14, no. 8, pp. 894–911, 2017. View at Publisher · View at Google Scholar
  • Denise Cristian Ferreira Neto, Marcelle de Souza Ferreira, Elaine da Conceição Petronilho, Josélia Alencar Lima, Sirlene Oliveira Francisco de Azeredo, Juliana de Oliveira Carneiro Brum, Claudia Jorge do Nascimento, and José Daniel Figueroa Villar, “A new guanylhydrazone derivative as a potential acetylcholinesterase inhibitor for Alzheimer's disease: synthesis, molecular docking, biological evaluation and kinetic studies by nuclear magnetic resonance,” RSC Adv., vol. 7, no. 54, pp. 33944–33952, 2017. View at Publisher · View at Google Scholar
  • Marcelli, Ficulle, Piccolo, Feligioni, and Corbo, “An overview of the possible therapeutic role of SUMOylation in the treatment of Alzheimer's disease,” Pharmacological Research, 2017. View at Publisher · View at Google Scholar
  • Hinawi A.M. Hassanin, Marwa Koko, Mohammed Abdalla, Wanmeng Mu, and Bo Jiang, “: a novel source of nutrition and medicine: a review,” Food Chemistry, 2018. View at Publisher · View at Google Scholar
  • Ji Sun Lee, Jang Hoon Kim, Yoo Kyong Han, Jin Yeul Ma, Young Ho Kim, Wei Li, and Seo Young Yang, “Cholinesterases inhibition studies of biological active compounds from the rhizomes of Alpinia officinarum Hance and in silico molecular dynamics,” International Journal of Biological Macromolecules, 2018. View at Publisher · View at Google Scholar
  • Xiaoming Xu, Jiang Wang, Naresh Pavurala, Yellela S. R. Krishnaiah, and Patrick J. Faustino, “Development and validation of a UPLC–MS method for the determination of galantamine in guinea pig plasma and its application to a pre-clinical bioavailability study of novel galantamine formulations,” Biomedical Chromatography, vol. 32, no. 9, 2018. View at Publisher · View at Google Scholar
  • Hoi Suk Kim, Min Chul Gim, Youn-Jung Kim, Cho Rong Kim, Soo Jung Choi, Jae Kyeom Kim, and Dong-Hoon Shin, “Erucamide from radish leaves has an inhibitory effect against acetylcholinesterase and prevents memory deficit induced by trimethyltin,” Journal of Medicinal Food, vol. 21, no. 8, pp. 769–776, 2018. View at Publisher · View at Google Scholar
  • Lukashenko, L. Ya. Zakharova, Sinyashin, Mirgorodskaya, Kushnazarova, and Kashapov, “Amphiphilic Compounds Containing a Carbamate Fragment: Synthesis, Aggregation, and Solubilizing Effect,” Russian Journal of Organic Chemistry, vol. 54, no. 7, pp. 987–991, 2018. View at Publisher · View at Google Scholar
  • Lucky Nwidu, Ekramy Elmorsy, Jonah Aprioku, Iyeopu Siminialayi, and Wayne Carter, “In Vitro Anti-Cholinesterase and Antioxidant Activity of Extracts of Moringa oleifera Plants from Rivers State, Niger Delta, Nigeria,” Medicines, vol. 5, no. 3, pp. 71, 2018. View at Publisher · View at Google Scholar
  • Mubashir Hassan, Sung-Yum Seo, Zeeshan Iqbal, Qamar Abbas, Saba Shahzadi, Hany Al Ashwal, Nazar Zaki, and Ahmed A. Moustafa, “Computational modeling and biomarker studies of pharmacological treatment of Alzheimer's disease (Review),” Molecular Medicine Reports, vol. 18, no. 1, pp. 639–655, 2018. View at Publisher · View at Google Scholar
  • Ji-Won Kim, Sungbin Im, Inil Lee, Kwan Joong Kim, Ha-Ram Jeong, Young Sung Jung, Seung Kook Park, and Dae-Ok Kim, “Neuroprotective effects of korean red pine (Pinus densiflora) bark extract and its phenolics,” Journal of Microbiology and Biotechnology, vol. 28, no. 5, pp. 679–687, 2018. View at Publisher · View at Google Scholar
  • Prayasee Baruah, Grace Basumatary, Semen O. Yesylevskyy, Kripamoy Aguan, Ghanashyam Bez, and Sivaprasad Mitra, “Novel coumarin derivatives as potent acetylcholinesterase inhibitors: insight into efficacy, mode and site of inhibition,” Journal of Biomolecular Structure and Dynamics, pp. 1–16, 2018. View at Publisher · View at Google Scholar
  • Fereshteh Shiri, Somayeh Pirhadi, and Jahan B. Ghasemi, “Dynamic structure based pharmacophore modeling of the Acetylcholinesterase reveals several potential inhibitors,” Journal of Biomolecular Structure and Dynamics, pp. 1–13, 2018. View at Publisher · View at Google Scholar
  • Jan Misik, Eugenie Nepovimova, Jaroslav Pejchal, Jiri Kassa, Jan Korabecny, and Ondrej Soukup, “Cholinesterase inhibitor 6-chlorotacrine -in vivo toxicological profile and behavioural effects,” Current Alzheimer Research, vol. 15, no. 6, pp. 552–560, 2018. View at Publisher · View at Google Scholar
  • Bilqees Sameem, Mina Saeedi, Mohammad Mahdavi, Hamid Nadri, Fahimeh Vafadarnejad, and Mohsen Amini, “ Synthesis and Characterization of Novel Phthalimide-pyrano[3,2- c ]chromene and Phthalimide-pyrano-2-one Hybrids ,” Journal of Heterocyclic Chemistry, 2018. View at Publisher · View at Google Scholar
  • Wakawa Ibrahim Abdu, Adebola Sodipo Olufunke, Adamu Mshelia Ibrahim, and Kundi Machina Babagana, “Hormone replacement therapy and Alzheimers disease in older women: A systematic review of literature,” Journal of Neuroscience and Behavioral Health, vol. 10, no. 1, pp. 1–8, 2018. View at Publisher · View at Google Scholar
  • Arunabha Ray, Harikesh Dubey, and Kavita Gulati, “Recent studies on cellular and molecular mechanisms in Alzheimer's disease: Focus on epigenetic factors and histone deacetylase,” Reviews in the Neurosciences, vol. 29, no. 3, pp. 241–260, 2018. View at Publisher · View at Google Scholar
  • Felipe Moraga-Nicolás, Claudia Jara, Ricardo Godoy, Patricio Iturriaga-Vásquez, Herbert Venthur, Andrés Quiroz, José Becerra, Ana Mutis, and Emilio Hormazábal, “Rhodolirium andicola : a new renewable source of alkaloids with acetylcholinesterase inhibitory activity, a study from nature to molecular docking,” Revista Brasileira de Farmacognosia, 2018. View at Publisher · View at Google Scholar
  • Thao Quyen Cao, Quynh-Mai Thi Ngo, Su Hui Seong, Ui Joung Youn, Jeong Ah Kim, Junheon Kim, Jin-Cheol Kim, Mi Hee Woo, Jae Sue Choi, and Byung Sun Min, “Cholinesterase inhibitory alkaloids from the rhizomes of Coptis chinensis,” Bioorganic Chemistry, 2018. View at Publisher · View at Google Scholar
  • Piyoosh Sharma, Pavan Srivastava, Ankit Seth, Prabhash Nath Tripathi, Anupam G. Banerjee, and Sushant K. Shrivastava, “Comprehensive review of mechanisms of pathogenesis involved in Alzheimer’s disease and potential therapeutic strategies,” Progress in Neurobiology, 2018. View at Publisher · View at Google Scholar
  • Daniela Volpato, and Ulrike Holzgrabe, “Designing Hybrids Targeting the Cholinergic System by Modulating the Muscarinic and Nicotinic Receptors: A Concept to Treat Alzheimer’s Disease,” Molecules, vol. 23, no. 12, pp. 3230, 2018. View at Publisher · View at Google Scholar
  • Svetlana S. Lukashenko, Alexandra D. Voloshina, Oxana A. Lenina, Alla B. Mirgorodskaya, Rushana A. Kushnazarova, Lucia Ya. Zakharova, and Oleg G. Sinyashin, “Carbamate-bearing surfactants: Micellization, solubilization, and biological activity,” Journal of Molecular Liquids, vol. 269, pp. 203–210, 2018. View at Publisher · View at Google Scholar
  • James T. Brewster, Simone Dell’Acqua, Danny Q. Thach, and Jonathan L. Sessler, “Classics in Chemical Neuroscience: Donepezil,” ACS Chemical Neuroscience, 2018. View at Publisher · View at Google Scholar
  • Thaiane Coelho dos Santos, Thaís Mota Gomes, Bruno Araújo Serra Pinto, Adriana Leandro Camara, and Antonio Marcus de Andrade Paes, “Naturally Occurring Acetylcholinesterase Inhibitors and Their Potential Use for Alzheimer's Disease Therapy,” Frontiers in Pharmacology, vol. 9, 2018. View at Publisher · View at Google Scholar
  • Fahimeh Vafadarnejad, Mohammad Mahdavi, Elahe Karimpour-Razkenari, Najmeh Edraki, Bilqees Sameem, Mahnaz Khanavi, Mina Saeedi, and Tahmineh Akbarzadeh, “Design and synthesis of novel coumarin-pyridinium hybrids: in vitro cholinesterase inhibitory activity,” Bioorganic Chemistry, 2018. View at Publisher · View at Google Scholar
  • Nashia Stellenboom, Murat Senturk, Kani Zilbeyaz, Murat Guney, and Aykut Oztekin, “Effects of aryl methanesulfonate derivatives on acetylcholinesterase and butyrylcholinesterase,” Journal of Biochemical and Molecular Toxicology, 2018. View at Publisher · View at Google Scholar
  • Thangavelu Lakshmi, Priyadarshini, and Roy Anitha, “Acetylcholinesterase inhibitory effect of capsicum oleoresins – An in vitro study,” International Journal of Research in Pharmaceutical Sciences, vol. 9, no. 4, pp. 1137–1140, 2018. View at Publisher · View at Google Scholar
  • Tejas Agnihotri, Gaurav Gupta, Sunil Kumar Dubey, Gautam Singhvi, Kowthavarapu Venkata Krishna, and Ranendra Narayan Saha, “Herbal medicines in neurodegenerative disorders: An evolutionary approach through novel drug delivery system,” Journal of Environmental Pathology, Toxicology and Oncology, vol. 37, no. 3, pp. 199–208, 2018. View at Publisher · View at Google Scholar
  • Mohammad Mahdavi, Roshanak Hariri, Seyedeh Sara Mirfazli, Hania Lotfian, Arezoo Rastergari, Omidreza Firuzi, Najmeh Edraki, Bagher Larijani, Tahmineh Akbarzadeh, and Mina Saeedi, “Synthesis and Biological Activity of Some Benzochromenoquinolinones: Tacrine Analogs as Potent Anti‐Alzheimer's Agents,” Chemistry & Biodiversity, 2019. View at Publisher · View at Google Scholar
  • Pavan Srivastava, Piyoosh Sharma, Avanish Tripathi, Surya Pratap Singh, Prabhash Nath Tripathi, Manish Kumar Tripathi, Ankit Seth, Sachchida Nand Rai, and Sushant K. Shrivastava, “Biphenyl-3-oxo-1,2,4-triazine linked piperazine derivatives as potential cholinesterase inhibitors with anti-oxidant property to improve the learning and memory,” Bioorganic Chemistry, vol. 85, pp. 82–96, 2019. View at Publisher · View at Google Scholar
  • Antonio Maia de Jesus Chaves Neto, Raul Nunes de Carvalho, Jorddy Neves da Cruz, Wanessa Almeida da Costa, Sérgio Henrique Brabo de Sousa, Fernanda Wariss Figueiredo Bezerra, Edinaldo Teixeira, Eloisa Helena de Aguiar Andrade, Mozaniel Santana de Oliveira, Sebastião Gomes Silva, and Nayara Janaína Neves da Silva, “Phytochemical profile, antioxidant activity, inhibition of acetylcholinesterase and interaction mechanism of the major components of the Piper divaricatum essential oil obtained by supercritical CO2,” Journal of Supercritical Fluids, pp. 74–84, 2019. View at Publisher · View at Google Scholar
  • Mohamad Fawzi Mahomoodally, Gokhan Zengin, Stefano Dall'Acqua, Karel Šmejkal, Ahmet Dogan, Mehmet Zeki Haznedaroglu, Stefania Sut, Filippo Maggi, Markéta Gazdová, Gizem Bulut, and Muhammad Zakariyyah Aumeeruddy, “Paeonia arietina and Paeonia kesrounansis bioactive constituents: NMR, LC-DAD-MS fingerprinting and in vitro assays,” Journal of Pharmaceutical and Biomedical Analysis, vol. 165, pp. 1–11, 2019. View at Publisher · View at Google Scholar
  • Yongfeng Wan, Shanshan Guan, Mengdan Qian, Houhou Huang, Fei Han, Song Wang, and Hao Zhang, “Structural Basis of Fullerene Derivatives as Novel Potent Inhibitors of Protein Acetylcholinesterase without Catalytic Active Site Interaction: Insight into the Inhibitory Mechanism through Molecular Modeling Studies,” Journal of Biomolecular Structure and Dynamics, pp. 1–21, 2019. View at Publisher · View at Google Scholar
  • Sumonto Mitra, Homira Behbahani, and Maria Eriksdotter, “Innovative Therapy for Alzheimer’s Disease-With Focus on Biodelivery of NGF,” Frontiers in Neuroscience, vol. 13, 2019. View at Publisher · View at Google Scholar
  • Mubashir Hassan, Hussain Raza, Muhammad Athar Abbasi, Ahmed A. Moustafa, and Sung-Yum Seo, “The exploration of novel Alzheimer’s therapeutic agents from the pool of FDA approved medicines using drug repositioning, enzyme inhibition and kinetic mechanism approaches,” Biomedicine & Pharmacotherapy, vol. 109, pp. 2513–2526, 2019. View at Publisher · View at Google Scholar
  • Lindon W. K. Moodie, Kristina Sepčić, Tom Turk, Robert Frangež, and Johan Svenson, “Natural cholinesterase inhibitors from marine organisms,” Natural Product Reports, 2019. View at Publisher · View at Google Scholar