CSF-Targeted Proteomics Indicate Amyloid-Beta Ratios in Patients with Alzheimer’s Dementia Spectrum

Table 2

Demographics and clinical characteristics of the study population.

	CN	MCI	AD	value
Number	225	381	113
Age (years)				<0.001
Gender (F/M)	126/99	173/208	45/68	0.007
Education (years)				0.011
Cognitive assessments
CDR				<0.001
ADAS-11				<0.001
ADAS-13				<0.001
MMSE				<0.001
Amyloid β
Aβ1-42				<0.001
Aβ1-42/1-40				<0.001
Aβ1-42/1-38				<0.001
Targeted proteomics
IASNTQSR				<0.001
VAELEDEK				<0.001
VVSSIEQK				<0.001
GDSVVYGLR				0.001
EPVAGDAVPGPK				0.004
QETLPSK				<0.001

CN: cognitively normal; MCI: mild cognitive impairment; AD: Alzheimer’s disease.