International Journal of Alzheimer’s Disease

Aß Behavior on Neuronal Membranes: Aggregation and Toxicities


Publishing date
15 Apr 2011
Status
Published
Submission deadline
15 Oct 2010

1Research Institute, National Center for Geriatrics and Gerontology, Obu, Aichi 474-8522, Japan

2Centre de Recherche en Neurobiologie et Neurophysiologie de Marseille (CRN2M), Université de la Méditerranée Aix-Marseille II et Université Paul Cézanne Aix-Marseille III, CNRS UMR 6231, INRA USC 2027, France

3Department of Medical Biophysics, Ontario Cancer Institute, University of Toronto, TMDT 4-305, 101 College Street, Toronto, ON, Canada M5G 1L7

4Neurobiology Laboratory for Brain Aging and Mental Health, Psychiatric University Clinics, University of Basel, 4025 Basel, Switzerland


Aß Behavior on Neuronal Membranes: Aggregation and Toxicities

Description

Aggregation and deposition of amyloid β-protein (Aβ) in brain is an invariable and initial event in the pathological process of Alzheimer's disease. Thus, one of the fundamental challenges regarding pathogenesis of Alzheimer's disease is to elucidate how Aβ starts to aggregate and how aggregated Aβ causes its toxicities against neurons. Recently, a body of evidence is growing that Aβ aggregation is facilitated in the presence of particular membranes lipids such as gangliosides and cholesterol and furthermore, that Aβ toxicities emerge through interaction with specific neuronal membrane microdomains such as lipid rafts.

We invite investigators to contribute original research articles as well as review articles that will provide novel information on this research area and stimulate research activities to understand the basic mechanism underlying early pathogenesis of Alzheimer's disease.

Potential topics include, but are not limited to:

  • Aβ interaction with cholesterol and sphingolipids
  • Effect of cholesterol on Aβ-membrane interaction
  • Aβ conformational changes on neuronal membranes (lipid rafts)
  • Aβ aggregation/oligomerization on neuronal membranes (lipid rafts)
  • Aβ toxicities on neuronal or intraneuronal membranes/organelles (e.g., mitochondria and ER)
  • Aβ-induced ion channel formation
  • Structure of Aβ oligomers in membranes: theoretical and experimental studies
  • Internalization of Aβ in neuronal cells

Before submission authors should carefully read over the journal's Author Guidelines, which are located at http://www.hindawi.com/journals/ijad/guidelines/. Prospective authors should submit an electronic copy of their complete manuscript through the journal Manuscript Tracking System at http://mts.hindawi.com/ according to the following timetable:


Articles

  • Special Issue
  • - Volume 2011
  • - Article ID 286536
  • - Editorial

Aβ Behavior on Neuronal Membranes: Aggregation and Toxicities

Katsuhiko Yanagisawa | Jacques Fantini | ... | Anne Eckert
  • Special Issue
  • - Volume 2011
  • - Article ID 695413
  • - Research Article

Intracellular APP Domain Regulates Serine-Palmitoyl-CoA Transferase Expression and Is Affected in Alzheimer's Disease

Marcus O. W. Grimm | Sven Grösgen | ... | Tobias Hartmann
  • Special Issue
  • - Volume 2011
  • - Article ID 304583
  • - Review Article

Membrane Incorporation, Channel Formation, and Disruption of Calcium Homeostasis by Alzheimer's β-Amyloid Protein

Masahiro Kawahara | Isao Ohtsuka | ... | Yutaka Sadakane
  • Special Issue
  • - Volume 2011
  • - Article ID 134971
  • - Review Article

Impacts of Membrane Biophysics in Alzheimer's Disease: From Amyloid Precursor Protein Processing to Aβ Peptide-Induced Membrane Changes

Sholpan Askarova | Xiaoguang Yang | James C.-M. Lee
  • Special Issue
  • - Volume 2011
  • - Article ID 925050
  • - Review Article

Amyloid-Beta Interaction with Mitochondria

Lucia Pagani | Anne Eckert
  • Special Issue
  • - Volume 2011
  • - Article ID 502386
  • - Research Article

Conjugated Quantum Dots Inhibit the Amyloid β (1–42) Fibrillation Process

Garima Thakur | Miodrag Micic | ... | Roger M. Leblanc
  • Special Issue
  • - Volume 2011
  • - Article ID 127984
  • - Review Article

Aβ Internalization by Neurons and Glia

Amany Mohamed | Elena Posse de Chaves
  • Special Issue
  • - Volume 2011
  • - Article ID 792070
  • - Research Article

ApoE4-Driven Accumulation of Intraneuronal Oligomerized Aβ42 following Activation of the Amyloid Cascade In Vivo Is Mediated by a Gain of Function

Lia Zepa | Moran Frenkel | ... | Daniel M. Michaelson
  • Special Issue
  • - Volume 2011
  • - Article ID 906964
  • - Review Article

Amyloid Oligomer Neurotoxicity, Calcium Dysregulation, and Lipid Rafts

Fiorella Malchiodi-Albedi | Silvia Paradisi | ... | Marco Diociaiuti
  • Special Issue
  • - Volume 2011
  • - Article ID 962352
  • - Research Article

Cell Surface Binding and Internalization of Aβ Modulated by Degree of Aggregation

David A. Bateman | Avijit Chakrabartty
International Journal of Alzheimer’s Disease
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