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International Journal of Breast Cancer
Volume 2012, Article ID 298623, 9 pages
http://dx.doi.org/10.1155/2012/298623
Review Article

The Hedgehog Pathway Conditions the Bone Microenvironment for Osteolytic Metastasis of Breast Cancer

Department of Oncologic Sciences, USA Mitchell Cancer Institute, Mobile, AL 36608, USA

Received 8 July 2011; Revised 6 September 2011; Accepted 8 September 2011

Academic Editor: Douglas R. Hurst

Copyright © 2012 Shamik Das et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Citations to this Article [14 citations]

The following is the list of published articles that have cited the current article.

  • Soyoung Im, Hyun Joo Choi, Changyoung Yoo, Ji-Han Jung, Ye-Won Jeon, Young Jin Suh, and Chang Suk Kang, “Hedgehog Related Protein Expression in Breast Cancer: Gli-2 Is Associated with Poor Overall Survival,” Korean Journal Of Pathology, vol. 47, no. 2, pp. 116–123, 2013. View at Publisher · View at Google Scholar
  • Shiwen Luo, Qi Chen, and Guolan Gao, “Hedgehog signaling pathway and ovarian cancer,” Chinese Journal Of Cancer Research, vol. 25, no. 3, pp. 346–353, 2013. View at Publisher · View at Google Scholar
  • Dimitrios Zardavas, and Jose Baselga, “Emerging targeted agents in metastatic breast cancer,” Nature Reviews Clinical Oncology, vol. 10, no. 4, pp. 191–210, 2013. View at Publisher · View at Google Scholar
  • Aamir Ahmad, “Pathways to breast cancer recurrence.,” ISRN oncology, vol. 2013, pp. 290568, 2013. View at Publisher · View at Google Scholar
  • Valentina Angeloni, Paola Tiberio, Valentina Appierto, and Maria Grazia Daidone, “Implications of stemness-related signaling pathways in breast cancer response to therapy,” Seminars in Cancer Biology, 2014. View at Publisher · View at Google Scholar
  • Thomas Tu, Magdalena A. Budzinska, Annette E. Maczurek, Robert Cheng, Anna Di Bartolomeo, Fiona J. Warner, Geoffrey W. McCaughan, Susan V. McLennan, and Nicholas A. Shackel, “Novel Aspects of the Liver Microenvironment in Hepatocellular Carcinoma Pathogenesis and Development,” International Journal of Molecular Sciences, vol. 15, no. 6, pp. 9422–9458, 2014. View at Publisher · View at Google Scholar
  • Michelle A. Hurchla, and Katherine N. Weilbaecher, “Hedgehog-targeted therapeutics uncouple the vicious cycle of bone metastasis,” OncoImmunology, vol. 1, no. 8, pp. 1411–1413, 2014. View at Publisher · View at Google Scholar
  • Se Young Park, Hyung Jeong Kim, Ki Rim Kim, Sun Kyoung Lee, Chang Ki Lee, Kwang-Kyun Park, and Won-Yoon Chung, “Betulinic acid, a bioactive pentacyclic triterpenoid, inhibits skeletal-related events induced by breast cancer bone metastases and treatment,” Toxicology and Applied Pharmacology, 2014. View at Publisher · View at Google Scholar
  • Md Shaifur Rahman, Naznin Akhtar, Hossen Mohammad Jamil, Rajat Suvra Banik, and Sikder M Asaduzzaman, “TGF-β/BMP signaling and other molecular events: regulation of osteoblastogenesis and bone formation,” Bone Research, vol. 3, pp. 15005, 2015. View at Publisher · View at Google Scholar
  • Deepika Raman, Chuan Han Jonathan Foo, Marie Veronique-Clement, and Shazib Pervaiz, “Breast Cancer: A Molecular and Redox Snapshot,” Antioxidants & Redox Signaling, 2016. View at Publisher · View at Google Scholar
  • Sheila Siqueira Andrade, Iuri Estrada Gouvea, Mariana Cristina C. Silva, Eloísa Dognani Castro, Cláudia A. A. de Paula, Debora Okamoto, Lilian Oliveira, Giovani Bravin Peres, Tatiana Ottaiano, Gil Facina, Afonso Celso Pinto Nazário, Antonio Hugo J. F. M. Campos, Edgar Julian Paredes-Gamero, Maria Juliano, Ismael D. C. G. da Silva, Maria Luiza V. Oliva, and Manoel J. B. C. Girão, “Cathepsin K induces platelet dysfunction and affects cell signaling in breast cancer - molecularly distinct behavior of cathepsin K in breast cancer,” BMC Cancer, vol. 16, no. 1, 2016. View at Publisher · View at Google Scholar
  • Tsuyoshi Shimo, Kenichi Matsumoto, Kiyofumi Takabatake, Eriko Aoyama, Yuichiro Takebe, Soichiro Ibaragi, Tatsuo Okui, Naito Kurio, Hiroyuki Takada, Kyoichi Obata, Pai Pang, Masahiro Iwamoto, Hitoshi Nagatsuka, and Akira Sasaki, “The Role of Sonic Hedgehog Signaling in Osteoclastogenesis and Jaw Bone Destruction,” Plos One, vol. 11, no. 3, 2016. View at Publisher · View at Google Scholar
  • Hyo Min Jeong, Sun Wook Cho, and Serk In Park, “Osteoblasts Are the Centerpiece of the Metastatic Bone Microenvironment,” Endocrinology and Metabolism, vol. 31, no. 4, pp. 485, 2016. View at Publisher · View at Google Scholar
  • Chuanqing Wu, Shaobo Hu, Ji Cheng, Guobin Wang, and Kaixiong Tao, “Smoothened antagonist GDC-0449 (Vismodegib) inhibits proliferation and triggers apoptosis in colon cancer cell lines,” Experimental and Therapeutic Medicine, vol. 13, no. 5, pp. 2529–2536, 2017. View at Publisher · View at Google Scholar