Research Article
Premenopausal Breast Cancer Risk Factors and Associations with Molecular Subtypes: A Case-Control Study
Table 4
Associations between risk factors and molecular subtypes.
| Risk factor | Luminal A () | Luminal B () | HER2 enriched () | Triple negative () | OR (95% CI) | | OR (95% CI) | | OR (95% CI) | | OR (95% CI) | |
| Sports activity | Yes | 2.07 (0.44-9.74) | 0.355 | 1.24 (0.25-6.03) | 0.785 | 2.16 (0.26-17.4) | 0.468 | 1.74 (0.31-9.62) | 0.526 | No | | | | | Alcohol intake | Yes | 1.79 (0.87-3.70) | 0.112 | 1.26 (0.49-3.19) | 0.624 | 1.05 (0.44-2.51) | 0.897 | 1.29 (0.50-3.36) | 0.591 | No | | | | | Obesity/overweight in past | Yes | 1.25 (0.62-2.52) | 0.527 | 0.47 (0.17-1.29) | 0.146 | 0.74 (0.31-1.74) | 0.495 | 2.35 (0.91-6.07) | 0.077 | No | | | | | Menstrual cycle regularity | Regular | | | | | Irregular | 1.07 (0.54-2.13) | 0.829 | 1.92 (0.74-4.99) | 0.179 | 1.06 (0.45-2.49) | 0.888 | 1.06 (0.41-2.73) | 0.899 | Menses quantity | Normal | | | | | Heavy | 0.60 (0.25-1.42) | 0.249 | 0.82 (0.30-2.27) | 0.826 | 0.78 (0.30-2.04) | 0.624 | 0.99 (0.32-3.01) | 0.992 | History of infertility | Yes | 1.01 (0.30-3.35) | 0.986 | 0.55 (0.14-2.16) | 0.399 | 0.39 (0.04-3.10) | 0.374 | — | No | | | | | Nulliparity | Yes | 1.2 (0.40-4.15) | 0.666 | 2.12 (0.63-7.17) | 0.224 | 1.78 (0.46-6.92) | 0.399 | 1.08 (0.21-5.41) | 0.921 | No | | | | | Contraception use | Yes | 1.98 (0.99-3.96) | 0.052 | 1.01 (0.41-2.47) | 0.987 | 240 (0.94-6.08) | 0.066 | 1.05 (0.41-2.67) | 0.914 | No | | | | | History of benign breast disease | Yes | 2.05 (0.56-7.41) | 0.271 | 0.76 (0.20-2.88) | 0.695 | 0.31 (0.10-0.91) | 0.035 | 0.66 (0.13-3.22) | 0.614 | No | | | | | Family history of breast cancer | Yes | 3.09 (1.02-9.37) | 0.045 | 0.45 (0.16-1.23) | 0.121 | 0.52 (0.14-1.86) | 0.317 | 0.61 (0.19-1.19) | 0.399 | No | | | | |
|
|