Premenopausal Breast Cancer Risk Factors and Associations with Molecular Subtypes: A Case-Control Study

Table 4

Associations between risk factors and molecular subtypes.

Risk factor	Luminal A ()		Luminal B ()		HER2 enriched ()		Triple negative ()
	OR (95% CI)		OR (95% CI)		OR (95% CI)		OR (95% CI)
Sports activity
Yes	2.07 (0.44-9.74)	0.355	1.24 (0.25-6.03)	0.785	2.16 (0.26-17.4)	0.468	1.74 (0.31-9.62)	0.526
No
Alcohol intake
Yes	1.79 (0.87-3.70)	0.112	1.26 (0.49-3.19)	0.624	1.05 (0.44-2.51)	0.897	1.29 (0.50-3.36)	0.591
No
Obesity/overweight in past
Yes	1.25 (0.62-2.52)	0.527	0.47 (0.17-1.29)	0.146	0.74 (0.31-1.74)	0.495	2.35 (0.91-6.07)	0.077
No
Menstrual cycle regularity
Regular
Irregular	1.07 (0.54-2.13)	0.829	1.92 (0.74-4.99)	0.179	1.06 (0.45-2.49)	0.888	1.06 (0.41-2.73)	0.899
Menses quantity
Normal
Heavy	0.60 (0.25-1.42)	0.249	0.82 (0.30-2.27)	0.826	0.78 (0.30-2.04)	0.624	0.99 (0.32-3.01)	0.992
History of infertility
Yes	1.01 (0.30-3.35)	0.986	0.55 (0.14-2.16)	0.399	0.39 (0.04-3.10)	0.374	—
No
Nulliparity
Yes	1.2 (0.40-4.15)	0.666	2.12 (0.63-7.17)	0.224	1.78 (0.46-6.92)	0.399	1.08 (0.21-5.41)	0.921
No
Contraception use
Yes	1.98 (0.99-3.96)	0.052	1.01 (0.41-2.47)	0.987	240 (0.94-6.08)	0.066	1.05 (0.41-2.67)	0.914
No
History of benign breast disease
Yes	2.05 (0.56-7.41)	0.271	0.76 (0.20-2.88)	0.695	0.31 (0.10-0.91)	0.035	0.66 (0.13-3.22)	0.614
No
Family history of breast cancer
Yes	3.09 (1.02-9.37)	0.045	0.45 (0.16-1.23)	0.121	0.52 (0.14-1.86)	0.317	0.61 (0.19-1.19)	0.399
No