Alteration of Sarcoplasmic Reticulum Ca²⁺ Release in Skeletal Muscle from Calpain 3-Deficient Mice

Figure 5

Peak amplitude of [Ca²⁺]_i response of myoblasts and myotubes to caffeine and CPA. Bar diagrams summarize the response of the cell types shown in Figure 4. (a) myoblasts (+/+); (b) myotubes (+/+); (c) myoblasts (−/−): application of 20 mM caffeine followed by 10 𝜇M CPA; (d) myotubes (−/−):  2 successive applications of 20 mM caffeine followed by 10 𝜇M CPA. The number of cells tested is given in brackets.

(a)

(b)

(c)

(d)