The ADF/Cofilin-Pathway and Actin Dynamics in Podocyte Injury

Figure 1

Regulatory pathways modulating cofilin phosphorylation and dephosphorylation Rho-GTPases are the predominant regulator of cofilin kinases and phosphatases. Cofilin phosphorylation is mainly regulated by LIMK and TESK. SSH family is the most important phosphatase that dephosphorylates cofilin directly or via LIMK inactivation. Phosphorylated cofilin can no longer bind and regulate the F-actin dynamics via treadmilling, severing, or nucleation.