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International Journal of Cell Biology
Volume 2012 (2012), Article ID 516789, 7 pages
http://dx.doi.org/10.1155/2012/516789
Review Article

Integrin Trafficking and Tumor Progression

Department of Cancer and Cell Biology, College of Medicine, University of Cincinnati, Cincinnati, OH 45267, USA

Received 27 July 2011; Accepted 12 September 2011

Academic Editor: Jun Chung

Copyright © 2012 Sejeong Shin et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Integrins are major mediators of cancer cell adhesion to extracellular matrix. Through this interaction, integrins play critical roles in cell migration, invasion, metastasis, and resistance to apoptosis during tumor progression. Recent studies highlight the importance of integrin trafficking, endocytosis and recycling, for the functions of integrins in cancer cells. Understanding the molecular mechanisms of integrin trafficking is pivotal for understanding tumor progression and for the development of anticancer drugs.