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International Journal of Cell Biology
Volume 2015, Article ID 563818, 8 pages
Review Article

Size Matters: Molecular Weight Specificity of Hyaluronan Effects in Cell Biology

Laboratory of Respiratory Biology, Department of Intramural Research, National Institute of Environmental Health Sciences, Research Triangle Park, NC 27709, USA

Received 7 October 2014; Accepted 5 January 2015

Academic Editor: Hans Hermann Gerdes

Copyright © 2015 Jaime M. Cyphert et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


Hyaluronan signaling properties are unique among other biologically active molecules, that they are apparently not influenced by postsynthetic molecular modification, but by hyaluronan fragment size. This review summarizes the current knowledge about the generation of hyaluronan fragments of different size and size-dependent differences in hyaluronan signaling as well as their downstream biological effects.