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International Journal of Cell Biology
Volume 2017, Article ID 5312951, 13 pages
https://doi.org/10.1155/2017/5312951
Review Article

Regeneration and Regrowth Potentials of Digit Tips in Amphibians and Mammals

1Department of Pediatric Surgery, University of Texas McGovern Medical School, Houston, TX 77030, USA
2Center for Stem Cell and Regenerative Medicine, The Brown Foundation Institute of Molecular Medicine for the Prevention of Human Diseases (IMM), The University of Texas Health Science Center at Houston (UT Health), Houston, TX 77030, USA
3Department of Orthopaedic Surgery, University of Texas McGovern Medical School, Houston, TX 77030, USA
4Center for Tissue Engineering and Aging Research, The IMM, The University of Texas Health Science Center at Houston (UT Health), Houston, TX 77030, USA
5Center for Regenerative Sports Medicine, Steadman Philippon Research Institute, Vail, CO, USA

Correspondence should be addressed to Yong Li; ude.cmt.htu@1.il.gnoy

Received 2 January 2017; Accepted 9 March 2017; Published 10 April 2017

Academic Editor: Michael Peter Sarras

Copyright © 2017 Yohan Choi et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Tissue regeneration and repair have received much attention in the medical field over the years. The study of amphibians, such as newts and salamanders, has uncovered many of the processes that occur in these animals during full-limb/digit regeneration, a process that is highly limited in mammals. Understanding these processes in amphibians could shed light on how to develop and improve this process in mammals. Amputation injuries in mammals usually result in the formation of scar tissue with limited regrowth of the limb/digit; however, it has been observed that the very tips of digits (fingers and toes) can partially regrow in humans and mice under certain conditions. This review will summarize and compare the processes involved in salamander limb regeneration, mammalian wound healing, and digit regeneration in mice and humans.