International Journal of Cell Biology

Cell Biology of Cysteine-Based Molecular Switches


Publishing date
27 Dec 2013
Status
Published
Submission deadline
09 Aug 2013

1Division of Molecular and Systems Toxicology, Department of Pharmaceutical Sciences, University of Basel, Basel, Switzerland

2Division of Protein Chemistry, Medical Institute of Bioregulation, Kyushu University, Japan

3CEA Life Sciences Division, Laboratoire Stress Oxydant et Cancers, CEA Saclay, Gif-sur-Yvette, France


Cell Biology of Cysteine-Based Molecular Switches

Description

Throughout biological kingdoms, the genetically encoded amino acids cysteine and selenocysteine fulfill many different functions. For instance, their ability to undergo reversible oxidation enables them to receive, carry, and propagate a variety of cellular signals. Alternatively, cysteine residues mediate protein folding, alter protein trafficking, or regulate protein activity. Depending on the context and the signal, oxidation of protein-bound cysteine results in cysteine sulfenic acid, S-nitrosocysteine, persulfide, or disulfide-bond formation. Importantly, cellular cysteine is also integrated into the abundant antioxidant molecule glutathione, which resides in all cell compartments and is fundamental for cell health.

In this special issue, we will present a collection of different cell biological outputs of cysteine/selenocysteine-centered switches. We invite authors to submit both original research and review articles. Potential topics include, but are not limited to:

Role of reversible cysteine/selenocysteine modifications in the following:

  • Signal transduction in health and disease
  • Redox regulation of interorganelle communication
  • Protein folding and secretion
  • Protein degradation and homeostasis
  • Membrane translocation and transport
  • Oxidative stress, DNA damage, and apoptosis
  • Redox homeostasis and antioxidant function
  • Metalloproteins and iron metabolism

Before submission authors should carefully read over the journal’s Author Guidelines, which are located at http://www.hindawi.com/journals/ijcb/guidelines/. Prospective authors should submit an electronic copy of their complete manuscript through the journal Manuscript Tracking System at http://mts.hindawi.com/submit/journals/ijcb/cyst/ according to the following timetable:


Articles

  • Special Issue
  • - Volume 2014
  • - Article ID 157038
  • - Editorial

Cell Biology of Cysteine-Based Molecular Switches

Christian Appenzeller-Herzog | Kenji Inaba | Agnès Delaunay-Moisan
  • Special Issue
  • - Volume 2014
  • - Article ID 715867
  • - Review Article

2-Cys Peroxiredoxins: Emerging Hubs Determining Redox Dependency of Mammalian Signaling Networks

Jinah Park | Sunmi Lee | ... | Sang Won Kang
  • Special Issue
  • - Volume 2014
  • - Article ID 913071
  • - Review Article

Linking Peroxiredoxin and Vacuolar-ATPase Functions in Calorie Restriction-Mediated Life Span Extension

Mikael Molin | Ayse Banu Demir
  • Special Issue
  • - Volume 2013
  • - Article ID 606703
  • - Review Article

Missing Links in Antibody Assembly Control

Tiziana Anelli | Eelco van Anken
  • Special Issue
  • - Volume 2013
  • - Article ID 797914
  • - Review Article

The Role of S-Nitrosylation and S-Glutathionylation of Protein Disulphide Isomerase in Protein Misfolding and Neurodegeneration

M. Halloran | S. Parakh | J. D. Atkin
  • Special Issue
  • - Volume 2013
  • - Article ID 769536
  • - Research Article

Cysteine-10 on 17β-Hydroxysteroid Dehydrogenase 1 Has Stabilizing Interactions in the Cofactor Binding Region and Renders Sensitivity to Sulfhydryl Modifying Chemicals

Lyubomir G. Nashev | Atanas G. Atanasov | ... | Alex Odermatt
  • Special Issue
  • - Volume 2013
  • - Article ID 742923
  • - Review Article

The Mitochondrial Disulfide Relay System: Roles in Oxidative Protein Folding and Beyond

Manuel Fischer | Jan Riemer
  • Special Issue
  • - Volume 2013
  • - Article ID 180906
  • - Review Article

Destroy and Exploit: Catalyzed Removal of Hydroperoxides from the Endoplasmic Reticulum

Thomas Ramming | Christian Appenzeller-Herzog
  • Special Issue
  • - Volume 2013
  • - Article ID 585431
  • - Review Article

Oxidative Protein-Folding Systems in Plant Cells

Yayoi Onda
  • Special Issue
  • - Volume 2013
  • - Article ID 898563
  • - Research Article

Quantifying Changes in the Cellular Thiol-Disulfide Status during Differentiation of B Cells into Antibody-Secreting Plasma Cells

Rosa E. Hansen | Mieko Otsu | ... | Jakob R. Winther
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