Previously, for the treatment of tissue defect, autogenous tissue grafts or various biomaterials were used for the transplantation to fulfill the defect. However, various shortcomings have been pointed out: substantial surgical invasion, reduced quality of life, lower success rate, less biocompatibility of artificial materials, and so on. Under such background, various studies for tissue engineering have recently been conducted to explore a new era of tissue defect treatment. In these studies, for the success in tissue engineering, three essential factors were examined successfully, that is, cells to be transplanted, signaling molecules, and scaffold. Currently, undifferentiated mesenchymal stem cells (MSCs) and dental tissues stem cells or their differentiated forms are transplanted with the appropriate scaffolds, producing excellent tissue regeneration. In addition, such signaling molecules as basic FGF, BDNF, BMP, and TGF-beta are demonstrated to induce new tissue formation. We invite authors to submit original research and review articles that seek the nature of tissue regeneration and the above-mentioned three factors. We are thus interested in articles that explore in vitro and in vivo aspects of tissue regeneration which is applicable to dentistry. Potential topics include, but are not limited to:

• Proliferation and differentiation of MSCs or dental stem cells and the relevant factors
• Cellular responses to various signaling molecules
• Cellular responses to artificial biomaterials to be used as scaffolds
• Animal models for the experiment of tissue engineering
• In vivo studies for tissue regeneration in artificially created tissue defects
• Confirmation for the safety of tissue regeneration
• Ethical consideration for tissue engineering

Before submission authors should carefully read over the journal's Author Guidelines, which are located at http://www.hindawi.com/journals/ijd/guidelines/. Prospective authors should submit an electronic copy of their complete manuscript through the journal Manuscript Tracking System at http://mts.hindawi.com/ according to the following timetable: