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International Journal of Endocrinology
Volume 2014 (2014), Article ID 983016, 7 pages
http://dx.doi.org/10.1155/2014/983016
Research Article

Genetic Variations in the Kir6.2 Subunit (KCNJ11) of Pancreatic ATP-Sensitive Potassium Channel Gene Are Associated with Insulin Response to Glucose Loading and Early Onset of Type 2 Diabetes in Childhood and Adolescence in Taiwan

1Department of Internal Medicine, National Taiwan University Hospital, 7 Chung-Shan South Road, Taipei 10002, Taiwan
2Graduate Institute of Preventive Medicine, School of Public Health, National Taiwan University, Taipei 10002, Taiwan
3Division of Endocrinology and Metabolism, Department of Internal Medicine, Cardinal Tien Hospital, Xindian 23148, Taiwan
4Department of Pediatrics, Mackay General Hospital, Taipei 10449, Taiwan
5Chia Nan University of Pharmacy and Science, Tainan 71710, Taiwan
6Institute of Environmental Health, College of Public Health, China Medical University, Taichung 40447, Taiwan

Received 2 May 2014; Accepted 20 August 2014; Published 21 September 2014

Academic Editor: Jyuhn-Huarng Juang

Copyright © 2014 Yi-Der Jiang et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

To investigate the role of E23K polymorphism of the KCNJ11 gene on early onset of type 2 diabetes in school-aged children/adolescents in Taiwan, we recruited 38 subjects with type 2 diabetes (ages 18.6 ± 6.6 years; body mass index percentiles 83.3 ± 15.4) and 69 normal controls (ages 17.3 ± 3.8 years; body mass index percentiles 56.7 ± 29.0) from a national surveillance for childhood/adolescent diabetes in Taiwan. We searched for the E23K polymorphism of the KCNJ11 gene. We found that type 2 diabetic subjects had higher carrier rate of E23K polymorphism of KCNJ11 gene than control subjects (P = 0.044). After adjusting for age, gender, body mass index percentiles, and fasting plasma insulin, the E23K polymorphism contributed to an increased risk for type 2 diabetes (P = 0.047). K23-allele-containing genotypes conferring increased plasma insulin level during OGTT in normal subjects. However, the diabetic subjects with the K23-allele-containing genotypes had lower fasting plasma insulin levels after adjustment of age and BMI percentiles. In conclusion, the E23K variant of the KCNJ11 gene conferred higher susceptibility to type 2 diabetes in children/adolescents. Furthermore, in normal glucose-tolerant children/adolescents, K23 allele carriers had a higher insulin response to oral glucose loading.