Review Article
Antifibrotic Activity of Acylated and Unacylated Ghrelin
Table 1
Changes of acylated ghrelin, unacylated ghrelin, and obestatin blood concentrations in human pathological conditions leading to organ fibrosis.
| Pathological condition | Acylated ghrelin | Unacylated ghrelin | Obestatin | Notes | Reference |
| Chronic heart failure (CHF) | ↑ | nd | nd | | [46] | ↓ | nd | nd | Acylated ghrelin levels positively correlate with favorable prognosis | [47] |
| Chronic hepatitis C | ↓ | nd | nd | Acylated ghrelin levels negatively correlate with fibrosis severity | [48] |
| Alcoholic hepatitis | ↓ | nd | nd | Acylated ghrelin levels negatively correlate with fibrosis severity | [48] |
| Nonalcoholic fatty liver disease (NAFLD) | nd | nd | = | | [90] |
| Nonalcoholic steatohepatitis (NASH) | = | ↑ | = | NASH versus non-NASH (among NAFLD patients) |
[50] | ↑ | = | ↑ | Severe NASH (fibrosis index ≥2) versus not severe NASH (fibrosis index <2) |
| Chronic obstructive pulmonary disease (COPD) | ↑ | nd | nd | Acylated ghrelin levels positively correlate with inflammation | [51] |
| Systemic sclerosis | ↓ | ↓ | nd | | [52] |
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