Table of Contents Author Guidelines Submit a Manuscript
International Journal of Endocrinology
Volume 2015, Article ID 439370, 11 pages
http://dx.doi.org/10.1155/2015/439370
Research Article

Anaplastic Thyroid Carcinoma: A ceRNA Analysis Pointed to a Crosstalk between SOX2, TP53, and microRNA Biogenesis

1Section of Cardio-Respiratory and Endocrine-Metabolic Diseases, Biomedical Department of Internal and Specialist Medicine (Di.Bi.M.I.S.), University of Palermo, Piazza delle Cliniche 2, 90127 Palermo, Italy
2Istituto Ortopedico Rizzoli (IOR), Section of Biology and Genetics, Department of Pathobiology and Medical and Forensic Biotechnology (Di.Bi.Me.F.), University of Palermo, Via Divisi 83, 90100 Palermo, Italy

Received 30 May 2014; Revised 28 August 2014; Accepted 10 September 2014

Academic Editor: Giuliana Salvatore

Copyright © 2015 Walter Arancio et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Linked References

  1. M. L. O'Connor, D. Xiang, S. Shigdar et al., “Cancer stem cells: a contentious hypothesis now moving forward,” Cancer Letters, vol. 344, no. 2, pp. 180–187, 2014. View at Publisher · View at Google Scholar · View at Scopus
  2. W. M. ElShamy and R. J. Duhé, “Overview: cellular plasticity, cancer stem cells and metastasis,” Cancer Letters, vol. 341, no. 1, pp. 2–8, 2013. View at Publisher · View at Google Scholar · View at Scopus
  3. E. Sugihara and H. Saya, “Complexity of cancer stem cells,” International Journal of Cancer, vol. 132, no. 6, pp. 1249–1259, 2013. View at Publisher · View at Google Scholar · View at Scopus
  4. Z. Yu, T. G. Pestell, M. P. Lisanti, and R. G. Pestell, “Cancer stem cells,” International Journal of Biochemistry and Cell Biology, vol. 44, no. 12, pp. 2144–2151, 2012. View at Publisher · View at Google Scholar · View at Scopus
  5. R. Lloyd, Z. Guo, and H. Hardin, “Cancer stem-like cells and thyroid cancer,” Endocrine-Related Cancer, 2014. View at Google Scholar
  6. J. Y. Yun, Y. A. Kim, J.-Y. Choe et al., “Expression of cancer stem cell markers is more frequent in anaplastic thyroid carcinoma compared to papillary thyroid carcinoma and is related to adverse clinical outcome,” Journal of Clinical Pathology, vol. 67, no. 2, pp. 125–133, 2014. View at Publisher · View at Google Scholar · View at Scopus
  7. H. Hardin, C. Montemayor-Garcia, and R. V. Lloyd, “Thyroid cancer stem-like cells and epithelial-mesenchymal transition in thyroid cancers,” Human Pathology, vol. 44, no. 9, pp. 1707–1713, 2013. View at Publisher · View at Google Scholar · View at Scopus
  8. V. Carina, G. Zito, G. Pizzolanti et al., “Multiple pluripotent stem cell markers in human anaplastic thyroid cancer: the putative upstream role of SOX2,” Thyroid, vol. 23, no. 7, pp. 829–837, 2013. View at Publisher · View at Google Scholar · View at Scopus
  9. L. Salmena, L. Poliseno, Y. Tay, L. Kats, and P. P. Pandolfi, “A ceRNA hypothesis: the rosetta stone of a hidden RNA language?” Cell, vol. 146, no. 3, pp. 353–358, 2011. View at Publisher · View at Google Scholar · View at Scopus
  10. R. Sen, S. Ghosal, S. Das, S. Balti, and J. Chakrabarti, “Competing endogenous RNA: the key to posttranscriptional regulation,” The Scientific World Journal, vol. 2014, Article ID 896206, 6 pages, 2014. View at Publisher · View at Google Scholar · View at Scopus
  11. F. A. Karreth and P. P. Pandolfi, “CeRNA cross-talk in cancer: when ce-bling rivalries go awry,” Cancer Discovery, vol. 3, no. 10, pp. 1113–1121, 2013. View at Publisher · View at Google Scholar · View at Scopus
  12. A. de Giorgioa, J. Krell, V. Harding, J. Stebbing, and L. Castellano, “Emerging roles of competing endogenous RNAs in cancer: insights from the regulation of PTEN,” Molecular & Cellular Biology, vol. 33, no. 20, pp. 3976–3982, 2013. View at Publisher · View at Google Scholar · View at Scopus
  13. X. Su, J. Xing, Z. Wang, L. Chen, M. Cui, and B. Jiang, “MicroRNAs and ceRNAs: RNA networks in pathogenesis of cancer,” Chinese Journal of Cancer Research, vol. 25, no. 2, pp. 235–239, 2013. View at Publisher · View at Google Scholar · View at Scopus
  14. X. Song, G. Cao, L. Jing et al., “Analysing the relationship between lncRNA and protein-coding gene and the role of lncRNA as ceRNA in pulmonary fibrosis,” Journal of Cellular and Molecular Medicine, vol. 18, no. 6, pp. 991–1003, 2014. View at Publisher · View at Google Scholar · View at Scopus
  15. X. Guo, M. Lin, S. Rockowitz, H. M. Lachman, and D. Zheng, “Characterization of human pseudogene-derived non-coding RNAs for functional potential,” PLoS ONE, vol. 9, no. 4, Article ID e93972, 2014. View at Publisher · View at Google Scholar · View at Scopus
  16. M. S. Kumar, E. Armenteros-Monterroso, P. East et al., “HMGA2 functions as a competing endogenous RNA to promote lung cancer progression,” Nature, vol. 505, no. 7482, pp. 212–217, 2014. View at Publisher · View at Google Scholar · View at Scopus
  17. W. Arancio, G. Pizzolanti, S. I. Genovese, C. Baiamonte, and C. Giordano, “Competing endogenous RNA and interactome bioinformatic analyses on human telomerase,” Rejuvenation Research, vol. 17, no. 2, pp. 161–167, 2014. View at Publisher · View at Google Scholar · View at Scopus
  18. W. Arancio, C. Giordano, and G. Pizzolanti, “A ceRNA analysis on LMNA gene focusing on the Hutchinson-Gilford progeria syndrome,” Journal of Clinical Bioinformatics, vol. 3, no. 1, article 2, 2013. View at Publisher · View at Google Scholar · View at Scopus
  19. W. Arancio, “A bioinformatics analysis of lamin—a regulatory network: a perspective on epigenetic involvement in hutchinson-gilford progeria syndrome,” Rejuvenation Research, vol. 15, no. 2, pp. 123–127, 2012. View at Publisher · View at Google Scholar · View at Scopus
  20. H. Dweep, C. Sticht, P. Pandey, and N. Gretz, “MiRWalk-database: prediction of possible miRNA binding sites by “walking” the genes of 3 genomes,” Journal of Biomedical Informatics, vol. 44, no. 5, pp. 839–847, 2011. View at Publisher · View at Google Scholar · View at Scopus
  21. D. Warde-Farley, S. L. Donaldson, O. Comes et al., “The GeneMANIA prediction server: biological network integration for gene prioritization and predicting gene function,” Nucleic Acids Research, vol. 38, supplement 2, pp. W214–W220, 2010. View at Publisher · View at Google Scholar · View at Scopus
  22. M. W. Pfaffl, G. W. Horgan, and L. Dempfle, “Relative expression software tool (REST) for group-wise comparison and statistical analysis of relative expression results in real-time PCR,” Nucleic acids research, vol. 30, no. 9, article e36, 2002. View at Publisher · View at Google Scholar · View at Scopus
  23. A. Bommarito, P. Richiusa, E. Carissimi et al., “BRAFV600E mutation, TIMP-1 upregulation, and NF-κB activation: closing the loop on the papillary thyroid cancer trilogy,” Endocrine-Related Cancer, vol. 18, no. 6, pp. 669–685, 2011. View at Publisher · View at Google Scholar · View at Scopus
  24. A. Criscimanna, G. Zito, A. Taddeo et al., “In vitro generation of pancreatic endocrine cells from human adult fibroblast-like limbal stem cells,” Cell Transplantation, vol. 21, no. 1, pp. 73–90, 2012. View at Publisher · View at Google Scholar · View at Scopus
  25. E. Doxakis, “Principles of miRNA-target regulation in metazoan models,” International Journal of Molecular Sciences, vol. 14, no. 8, pp. 16280–16302, 2013. View at Publisher · View at Google Scholar · View at Scopus
  26. C.-P. Lin, Y. J. Choi, G. G. Hicks, and L. He, “The emerging functions of the p53-miRNA network in stem cell biology,” Cell Cycle, vol. 11, no. 11, pp. 2063–2072, 2012. View at Publisher · View at Google Scholar · View at Scopus
  27. D. M. Popović, “Current advances in research of cytochrome c oxidase,” Amino Acids, vol. 45, no. 5, pp. 1073–1087, 2013. View at Publisher · View at Google Scholar · View at Scopus
  28. R. G. Pestell, “New roles of cyclin D1,” American Journal of Pathology, vol. 183, no. 1, pp. 3–9, 2013. View at Publisher · View at Google Scholar · View at Scopus
  29. E. Choi and K. C. Hwang, “MicroRNAs as novel regulators of stem cell fate,” World Journal of Stem Cells, vol. 5, no. 4, pp. 172–187, 2013. View at Google Scholar
  30. J. Jia, P. Yao, A. Arif, and P. L. Fox, “Regulation and dysregulation of 3′UTR-mediated translational control,” Current Opinion in Genetics and Development, vol. 23, no. 1, pp. 29–34, 2013. View at Publisher · View at Google Scholar · View at Scopus
  31. J. T. Huang, J. Wang, V. Srivastava, S. Sen, and S. M. Liu, “MicroRNA machinery genes as novel biomarkers for cancer,” Frontiers in Oncology, vol. 4, article 113, 2014. View at Publisher · View at Google Scholar
  32. P. A. Muller and K. H. Vousden, “Mutant p53 in cancer: new functions and therapeutic opportunities,” Cancer Cell, vol. 25, no. 3, pp. 304–317, 2014. View at Google Scholar
  33. V. G. Antico Arciuch, M. A. Russo, M. Dima et al., “Thyrocyte-specific inactivation of p53 and Pten results in anaplastic thyroid carcinomas faithfully recapitulating human tumors,” Oncotarget, vol. 2, no. 12, pp. 1109–1126, 2011. View at Google Scholar · View at Scopus
  34. L. Boominathan, “The tumor suppressors p53, p63, and p73 are regulators of microRNA processing complex,” PLoS ONE, vol. 5, no. 5, Article ID e10615, 2010. View at Publisher · View at Google Scholar · View at Scopus
  35. Z. Yu, L. Wang, C. Wang et al., “Cyclin D1 induction of dicer governs microRNA processing and expression in breast cancer,” Nature Communications, vol. 4, article 2812, 2013. View at Publisher · View at Google Scholar · View at Scopus
  36. X. Xu, S. Duan, F. Yi, A. Ocampo, G.-H. Liu, and J. C. Izpisua Belmonte, “Mitochondrial regulation in pluripotent stem cells,” Cell Metabolism, vol. 18, no. 3, pp. 325–332, 2013. View at Publisher · View at Google Scholar · View at Scopus