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International Journal of Endocrinology
Volume 2015, Article ID 439370, 11 pages
Research Article

Anaplastic Thyroid Carcinoma: A ceRNA Analysis Pointed to a Crosstalk between SOX2, TP53, and microRNA Biogenesis

1Section of Cardio-Respiratory and Endocrine-Metabolic Diseases, Biomedical Department of Internal and Specialist Medicine (Di.Bi.M.I.S.), University of Palermo, Piazza delle Cliniche 2, 90127 Palermo, Italy
2Istituto Ortopedico Rizzoli (IOR), Section of Biology and Genetics, Department of Pathobiology and Medical and Forensic Biotechnology (Di.Bi.Me.F.), University of Palermo, Via Divisi 83, 90100 Palermo, Italy

Received 30 May 2014; Revised 28 August 2014; Accepted 10 September 2014

Academic Editor: Giuliana Salvatore

Copyright © 2015 Walter Arancio et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Supplementary Material

In order to analyse the basal expression of SOX2 and the ceRNA genes in different specimens we analysed by RT-PCR the relative expression of SOX2 and SOX2 ceRNAs compared to β-ACTIN expression in: SW1736 ATC cell line, 8505C ATC cell line, C643 ATC cell line, FRO ATC cell line, BCPAP papillary thyroid carcinoma (PTC) cell line, TPC- 1 PTC cell line, WRO follicular thyroid carcinoma, a pool of normal thyroid tissues, a pool of limbal stem cells, and isolated lymphocytes from a male donor of 36 years old. These data have been used to thest theri correlation as reported in Table 9.

  1. Supplementary Material