International Journal of Endocrinology

International Journal of Endocrinology / 2015 / Article

Clinical Study | Open Access

Volume 2015 |Article ID 542641 |

Tae-Yon Sung, Yu-mi Lee, Jong Ho Yoon, Ki-Wook Chung, Suck Joon Hong, "Long-Term Effect of Surgery in Graves’ Disease: 20 Years Experience in a Single Institution", International Journal of Endocrinology, vol. 2015, Article ID 542641, 6 pages, 2015.

Long-Term Effect of Surgery in Graves’ Disease: 20 Years Experience in a Single Institution

Academic Editor: Constantinos Pantos
Received17 Feb 2015
Revised27 Apr 2015
Accepted30 Apr 2015
Published12 May 2015


The present study compared the long-term outcome of subtotal thyroidectomy (ST) to that of total thyroidectomy (TT) in Graves’ disease (GD). Patients with GD requiring surgery were divided between two groups: ST and TT. Postoperative thyroid function (PoTF) changes, including hypothyroidism, euthyroidism, and hyperthyroidism, and surgical complications were analyzed 3 months and 2 years after surgery. During the study period, 350 GD patients underwent surgery, of whom 254 underwent ST and 96 underwent TT. In the ST group, the rates of hypothyroidism, euthyroidism, and hyperthyroidism were 92.5%, 6.7%, and 0.4%, respectively, after 3 months, and 86.1%, 8.6%, and 5.3%, respectively, after 2 years. No difference in the rate of surgical complication was observed between the ST and TT groups . Most of the ST patients showed hypothyroidism after surgery, and euthyroidism was rare. The long-term outcome of ST included noticeable PoTF changes and recurrence of GD. These results suggest that TT should be considered as a treatment option in GD requiring surgery.

1. Introduction

The three main treatment modalities for Graves’ disease (GD) are antithyroid drug therapy, radioactive iodine therapy, and thyroid surgery [1]. Antithyroid drug therapy and radioactive iodine therapy are selected more frequently than surgery in early-stage GD [24]; however, in GD patients with symptomatic compression or large goiters, suspicion of malignancy, low uptake of radioactive iodine (RAI), a pregnancy planned within 6 months, or severe ophthalmopathy, thyroidectomy is the preferred modality despite the risks associated with surgery [57].

Thyroid surgery options for GD include subtotal thyroidectomy (ST) and total thyroidectomy (TT). In the past, ST, which preserves a functional thyroid remnant, was the standard choice, and many surgeons still prefer it. ST was also preferred because of its lower incidence of surgical complications than TT [8]. TT has been performed since the early 1960s [9] in limited cases including pediatric GD, serious side effects from antithyroid drugs, and suspicion of thyroid malignancy [10].

The advantages of ST include the maintenance of thyroid function, that is, euthyroidism, and the expectation of fewer surgical complications such as hypoparathyroidism and recurrent laryngeal nerve injury [5]; however, lack of complication after ST is not guaranteed by all surgeons, and hypothyroidism or hyperthyroidism recurrence rates differ between surgical techniques [8]. By contrast, TT prevents recurrence with certainty [11]. Recent studies showed that the incidence of surgical complications was not significantly different between ST and TT [1115]; hence, we compared long-term postoperative thyroid function (PoTF) between ST and TT.

2. Methods

Consecutive GD patients requiring surgery between December 1995 and December 2010 were included in the study. A retrospective review of the clinical data was performed, and the patients were divided into two groups: the ST and TT groups. Patients showing low compliance during follow-up, such as patients who missed appointments or changed institution after surgery, and patients for whom surgical data were not available or did not include the weight of the remnant thyroid after ST were excluded. The diagnosis of GD was made when clinically enlarged thyroid goiter was found with thyroid associated ophthalmopathy and the measurement of thyroid-stimulation hormone binding inhibitor immunoglobulin to distinguish the reason of hyperthyroidism from others such as toxic multinodular goiter. Thyroid scan uptake examination was performed when in need. Thyroidectomy was performed by a single experienced endocrine surgeon (SJH). The surgical procedure was processed in the same manner for ST and TT. The diagnosis of GD was mainly performed from medical department by the TFT examinations and was sent for surgery when in need.

Two ST procedures were used: bilateral ST in which remnant thyroid was left at both upper pole areas and ipsilateral total thyroidectomy with contralateral ST (Hartley-Dunhill procedure). In ST, the amount of remnant thyroid was estimated by measuring a portion of resected thyroid cut into similar size and shape. The weight of the recut thyroid specimen that mimics the remnant thyroid was measured and recorded during surgery after each ST. The measurement was made by the operating surgeon based on his experience, the degree of hyperthyroidism, and thyroid gross findings. TT was recommended and performed mostly in younger patients and in patients with severe Graves’ ophthalmopathy; however, the gradual change in surgical method preference from ST to TT over time was represented. Thyroid function tests (TFT) were performed after surgery in all cases, including T3 (98–180 ng/dL), thyroid-stimulating hormone (TSH) (0.4–5.0 μU/mL), free T4 (fT4) (0.8–1.9 ng/dL), thyroglobulin (1.0–23.3 ng/mL), and anti-thyroglobulin antibody (0.0–60.0 U/mL). In ST, PoTF was measured to assess the change in thyroid function, and in TT, it was measured to determine the dosage of thyroid hormone. The first PoTF was measured 3 months after surgery, the second 6 months after surgery, and the third after 1 year of follow-up. Thereafter, the PoTF was measured yearly. At each visit, the need for thyroid hormone administration was assessed based on the PoTF measurement and symptoms of abnormal thyroid function. The thyroid hormone drug (or antithyroid hormone drug) was administered at any point when hypothyroidism or hyperthyroidism was diagnosed. The definition of hypothyroidism, euthyroidism, and hyperthyroidism was as follows: hypothyroidism (TFT including TSH above and fT4 below the normal range), euthyroidism (TFT including TSH and fT4 within the normal range), and hyperthyroidism (TFT including TSH below and fT4 above the normal range). To further assess changes in PoTF in ST, hypothyroidism and hyperthyroidism were subdivided into subclinical and clinical. Subclinical hypothyroidism was defined as hypothyroidism in TFT without thyroid hormone therapy, and clinical hypothyroidism was defined as hypothyroidism in TFT with thyroid hormone therapy. Subclinical hyperthyroidism was defined as hyperthyroidism in TFT without antithyroid drug therapy, and clinical hyperthyroidism was defined as hyperthyroidism in TFT with antithyroid drug therapy. PoTF was assessed for more than 2 years in the out-patient department to determine the long-term effect of ST. Recurrence of GD after surgery was defined as postoperative clinical hyperthyroidism requiring treatment with antithyroid drug therapy or RAI therapy after 2 years of follow-up. Surgical complications were compared between ST and TT including postoperative bleeding, recurrent laryngeal nerve injury, hypoparathyroidism, and wound seroma.

Statistical analysis was performed using SPSS Statistics, version 21 (IBM). Variables were compared by chi-square test or Fisher’s exact test. A was considered significant. Data are reported as number (percentage), unless otherwise stated.

3. Results

Three hundred and sixty consecutive patients underwent thyroidectomy for GD, and 350 were enrolled in the study. Ten patients were excluded based on the criteria outlined in the methods. Of the 350 cases, 254 underwent ST and 96 underwent TT. In the TT group, six patients underwent initial ST and subsequent TT when final histopathology reported GD with occult thyroid carcinoma. The change in preferred surgical procedure from ST to TT that occurred over the years at the study institution shows a large increase in TT and a clear shift from ST to TT in 2010 (Figure 1).

The gender ratio showed a predominance of females over males (77.1 versus 22.9%). The median age at surgery was 30 years old. The median resected thyroid weight was 70.6 g, and the weight was larger in ST group than TT group, 84.9 g and 32.5 g, respectively, with statistical significance (). The median follow-up duration was 61.0 months. Ophthalmopathy was accompanied in 26.0% of the patients. The most frequent reasons for undergoing surgery for GD were resistance to antithyroid drug therapy (55.7%). The incidence of thyroid carcinoma presented in GD was 79 out of 350 patients (22.6%) of which 74 underwent TT. Of them, all presented as papillary thyroid carcinoma. The median size of papillary thyroid carcinoma was 0.83 cm (Table 1).

Clinical characteristicsAll Subtotal thyroidectomyTotal thyroidectomy
( = 350)( = 254)( = 96)

Age at surgery (year): median, IQR30(24, 39)28(23, 34)39(31.3, 50)
Resected thyroid weight (gram): median, range70.6(12.0–361.0)84.9(13.8–361.0)32.5(12.0–160.0)
Follow-up duration after surgery (month): median, IQR61(24, 103.3)57(23, 107)63.5(28.3, 91.8)
Reasons for surgery
 Resistance to ATD19555.7%17970.5%1616.7%
 Symptomatic large goiter246.9%228.7%22.1%
 Suspicious undetermined mass216.0%124.7%99.4%
 Suspicion of malignancy6719.1%06769.8%
 Patient’s desire339.4%3112.2%22.1%
 Others (not described)102.90%103.9%0
Incidence of thyroid carcinoma presented7922.6%52.0%7477.1%
Papillary thyroid carcinoma size (cm): median, range0.83(0.2–5.2)0.38(0.3–0.5)0.88(0.2–5.2)

IQR: interquartile range; ATD: antithyroid hormone drug.
All the thyroid carcinomas presented in Graves’ disease were papillary thyroid carcinomas.

The PoTF 3 months after ST showed hypothyroidism in 235 patients (92.5%), euthyroidism in 17 patients (6.7%), and hyperthyroidism in 1 patient (0.4%). The ST group was divided into three subgroups based on remnant thyroid weight: <4.0 g (73 patients; 28.7%), ≥4.0 g and <6.0 g (153 patients; 60.2%), and ≥6.0 g (28 patients; 11.1%). A close relationship was observed between the weight of the thyroid remnant and PoTF: hypothyroidism was associated with smaller remnant thyroid, and hyperthyroidism was associated with larger remnant thyroid; however, the difference was not significant () (Table 2). All TT patients showed hypothyroidism after surgery with no PoTF changes.

Postoperative thyroid functionRemnant thyroid weight
Subtotal thyroidectomy ( = 254)<4.0 g ≥4.0 g and <6.0 g ≥6.0 g
( = 73)( = 153)( = 28)

Hypothyroidism235 92.5%69 95.8%141 92.2%25 89.3%0.671
Euthyroidism17 6.7%3 4.2%11 7.2%3 10.7%
Hyperthyroidism1 0.4%0 1 0.7%0

Two hundred and nine ST patients came to the out-patient department for their scheduled follow-up for more than 2 years after surgery. In most of the patients with either hypothyroidism or hyperthyroidism, the change in PoTF over time was detected within the first 6 months of follow-up. After ST, hyperthyroidism developed gradually over time, while hypothyroidism, in most cases, was diagnosed within a year after surgery (Figure 2). In the ST group, 15 patients presented with euthyroidism at 3 months and, thereafter, nine of them evolved to clinical hypothyroidism, and one evolved to clinical hyperthyroidism. One hundred and ninety-three patients presented with hypothyroidism at 3 months, 13 of whom went on to develop euthyroidism and nine went on to develop clinical hyperthyroidism. Hyperthyroidism was present in one patient in whom no change in PoTF was observed during the 2 years of follow-up. No early subclinical hypothyroidism, early clinical hyperthyroidism, or late subclinical hyperthyroidism was detected during the study period (Table 3). Among the 209 ST patients who complied with the scheduled follow-up protocol, 11 (5.2%) developed clinical hyperthyroidism over time that qualified as GD recurrence requiring additional therapy such as antithyroid drug therapy () or RAI therapy (). By contrast, no recurrence was observed in the TT group. No significant difference in surgical complication rate was observed between the ST and TT groups (Table 4).

Follow-up: 2 years
Postoperative thyroid functionHypothyroidism Euthyroidism ( = 18)Hyperthyroidism 
Clinical ( = 11)
Subclinical ( = 9)Clinical ( = 171)

Follow-up: 3 monthsHypothyroidismClinical ( = 193)9 162 13 9
Euthyroidism ( = 15)0 9 5 1
HyperthyroidismSubclinical ( = 1)0 0 0 1

ComplicationsSubtotal thyroidectomy Total thyroidectomy
( = 254)( = 96)

Complications (total)0.089
 No222 87.4%90 93.8%
 Yes32 12.6%6 6.3%
Types of complication
 Postoperative bleeding requiring surgical exploration6 2.4%2 2.1%
 Transient hypoparathyroidism24 9.4%4 4.2%
 Permanent hypoparathyroidism1 0.4%0
 Recurrent laryngeal nerve injury0 0
 Wound seroma1 0.4%0

4. Discussion

The most acknowledged benefit of ST in GD is maintenance of PoTF in euthyroidism after surgery. Palit et al. [8] meta-analyzed 35 studies of ST in GD and reported that an average of 59.7% of the patients presented with euthyroidism after surgery; however, the rate of euthyroidism or postoperative thyroid dysfunction varies greatly, with hypothyroidism observed in 4.0–83.0% of the cases and recurrence in 1.0–14.6% of the cases [12, 14, 1619].

Thus, there are many reasons for the wide range of postoperative thyroid dysfunction after ST. First, the definition of dysfunction can differ based on PoTF range criteria. When hypothyroidism or hyperthyroidism is defined as abnormal TFT without being correlated with patient symptoms, the rate of dysfunction may increase. Secondly, the amount of remnant thyroid may differ between surgeons, and procedures for measuring the weight of remnant thyroid may vary between institutions; as a result, the PoTF may change even though the same amount of remnant thyroid weight is recorded. Thirdly, the iodine intake may differ between populations and could affect the PoTF. The rate of postoperative hypothyroidism is lower in regions with high intake of iodine [20]. Koreans take in high levels of iodine since the peninsula is surrounded by the ocean on three sides. Nonetheless, a high rate of hypothyroidism after ST was observed in this study.

Recent studies published in the 2000s reported increased rate of dysfunction after ST in GD more frequently than did earlier studies [12, 14]. Lal et al. [14] reported a high postoperative hypothyroidism rate, up to 83.0%, the reason for which could be the strict application of hypothyroidism criteria or an insufficient amount of remnant thyroid. Another important reason for thyroid dysfunction after surgery for GD is the duration of follow-up and level of compliance and how accurately those parameters were measured. The technical accuracy of TFT has increased over time, and results are now uniformly applied worldwide, which may have increased the detection of thyroid dysfunction after surgery [21]. Thyroid function changes over time, as long observation periods have shown [22].

In this study, most of the hypothyroidism occurred within several months after ST, and incidence decreased thereafter; by contrast, recurrence gradually increased over time although recurrence rates were low. As in the study by Noh et al. [18], most ST patients presented hypothyroidism in early postoperative TFT, and a gradual increase in the recurrence rate was observed upon long-term follow-up. Only few patients maintained euthyroidism after ST. Also, such results might have been derived from the condition that the patients after TT have received an adequate amount of thyroid hormone medication based on the generalized dosage protocol according to their body weight, and instead in ST, patients would have required adjustment duration to reach the adequate thyroid hormone levels. These results may suggest that TT is a better surgical option than ST in GD since no PoTF fluctuation or recurrence is observed after TT.

One may argue that TT presents a potentially high risk of surgical complications. Studies comparing surgical complications between ST and TT in GD showed a higher rate of transient complications but no significant differences in permanent complications. Previous reports showed that the surgical complication rate was higher after TT than after ST [1215]; however, in this study, the overall rate of complication was higher in ST than in TT, mostly of transient hypoparathyroidism, although no statistical significance was reached. This might be explained by the overall resected thyroid weight difference. The ST group median thyroid weight was measured larger than the TT group, maybe because one of the reasons for TT was suspicion of malignancy rather than the symptomatic large goiter. Fortunately, no recurrent laryngeal nerve injury was observed during the study period, likely a consequence of the fact that a single experienced surgeon performed the surgery even though routine laryngoscopy was not used. These findings, including that of a lower complication rate in TT than ST, could explain why preference for TT over ST has increased over time. Interestingly, even though severe ophthalmopathy was a TT indicator in our institution, the rate of ophthalmopathy was higher in ST group than TT group (29.1 versus 17.7%). Fortunately, none of the patients presented detectable progression of ophthalmopathy after the surgery. The limitation of this study may be that the number of patients who underwent ST was larger than the number who underwent TT, affecting the comparison of complication risk and the suggestion that complication risk explains the trend toward greater selection of TT over ST over time.

5. Conclusion

In ST performed for GD, the rate of hypothyroidism in early PoTF was very high with only few patients presenting with euthyroidism. Indeed, recent studies reported a higher rate of postoperative thyroid dysfunction in ST than in TT, with increased dysfunction over time. In addition, no significant difference in surgical complication rates was observed between ST and TT. Therefore, to reduce potential long-term dysfunction and GD recurrence after surgery, TT may be more beneficial than ST in GD requiring surgery in experienced endocrine surgeon.

Conflict of Interests

The authors declare that there is no conflict of interests regarding the publication of this paper.


  1. B. T. Muldoon, V. Q. Mai, and H. B. Burch, “Management of graves' disease: an overview and comparison of clinical practice guidelines with actual practice trends,” Endocrinology and Metabolism Clinics of North America, vol. 43, no. 2, pp. 495–516, 2014. View at: Publisher Site | Google Scholar
  2. R. S. Bahn, H. B. Burch, D. S. Cooper et al., “Hyperthyroidism and other causes of thyrotoxicosis: management guidelines of the American Thyroid Association and American Association of Clinical Endocrinologists,” Thyroid, vol. 21, no. 6, pp. 593–646, 2011. View at: Publisher Site | Google Scholar
  3. H. B. Burch, K. D. Burman, and D. S. Cooper, “A 2011 survey of clinical practice patterns in the management of graves' disease,” The Journal of Clinical Endocrinology & Metabolism, vol. 97, no. 12, pp. 4549–4558, 2012. View at: Publisher Site | Google Scholar
  4. B. Solomon, D. Glinoer, R. Lagasse, and L. Wartofsky, “Current trends in the management of Graves' disease,” Journal of Clinical Endocrinology and Metabolism, vol. 70, no. 6, pp. 1518–1524, 1990. View at: Publisher Site | Google Scholar
  5. R. S. Bahn, H. B. Burch, D. S. Cooper et al., “Hyperthyroidism and other causes of thyrotoxicosis: management guidelines of the American Thyroid Association and American Association of Clinical Endocrinoloigists,” Endocrine Practice, vol. 17, no. 3, pp. 456–520, 2011. View at: Publisher Site | Google Scholar
  6. J. Yip, B. H.-H. Lang, and C.-Y. Lo, “Changing trend in surgical indication and management for Graves' disease,” The American Journal of Surgery, vol. 203, no. 2, pp. 162–167, 2012. View at: Publisher Site | Google Scholar
  7. P. Werga-Kjellman, J. Zedenius, L. Tallstedt, F. Träisk, G. Lundell, and G. Wallin, “Surgical treatment of hyperthyroidism: a ten-year experience,” Thyroid, vol. 11, no. 2, pp. 187–192, 2001. View at: Publisher Site | Google Scholar
  8. T. K. Palit, C. C. Miller III, and D. M. Miltenburg, “The efficacy of thyroidectomy for Graves' disease: a meta-analysis,” Journal of Surgical Research, vol. 90, no. 2, pp. 161–165, 2000. View at: Publisher Site | Google Scholar
  9. S. L. Perzik and B. Catz, “The place of total thyroidectomy in the management of thyroid disease,” Surgery, vol. 62, no. 3, pp. 436–440, 1967. View at: Google Scholar
  10. H. Dralle, “Current status of total thyroidectomy in thyroid-associated orbitopathy,” Experimental and Clinical Endocrinology and Diabetes, vol. 107, supplement 5, pp. S195–S197, 1999. View at: Publisher Site | Google Scholar
  11. S. M. Wilhelm and C. R. McHenry, “Total thyroidectomy is superior to subtotal thyroidectomy for management of graves' disease in the United States,” World Journal of Surgery, vol. 34, no. 6, pp. 1261–1264, 2010. View at: Publisher Site | Google Scholar
  12. C.-F. Ku, C.-Y. Lo, W.-F. Chan, A. W. C. Kung, and K. S. L. Lam, “Total thyroidectomy replaces subtotal thyroidectomy as the preferred surgical treatment for Graves' disease,” ANZ Journal of Surgery, vol. 75, no. 7, pp. 528–531, 2005. View at: Publisher Site | Google Scholar
  13. P. Miccoli, P. Vitti, T. Rago et al., “Surgical treatment of Graves' disease: subtotal or total thyroidectomy?” Surgery, vol. 120, no. 6, pp. 1020–1025, 1996. View at: Publisher Site | Google Scholar
  14. G. Lal, P. Ituarte, E. Kebebew, A. Siperstein, Q.-Y. Duh, and O. H. Clark, “Should total thyroidectomy become the preferred procedure for surgical management of Graves' Disease?” Thyroid, vol. 15, no. 6, pp. 569–574, 2005. View at: Publisher Site | Google Scholar
  15. M. S. Barakate, G. Agarwal, T. S. Reeve, B. Barraclough, B. Robinson, and L. W. Delbridge, “Total thyroidectomy is now the preferred option for the surgical management of graves' disease,” ANZ Journal of Surgery, vol. 72, no. 5, pp. 321–324, 2002. View at: Publisher Site | Google Scholar
  16. M. B. Farnell, J. A. van Heerden, W. M. McConahey, H. A. Carpenter, and L. H. Wolff Jr., “Hypothyroidism after thyroidectomy for Graves' disease,” The American Journal of Surgery, vol. 142, no. 5, pp. 535–538, 1981. View at: Publisher Site | Google Scholar
  17. S. Noguchi, N. Murakami, and A. Noguchi, “Surgical treatment for Graves' disease: a long term follow-up of 325 patients,” British Journal of Surgery, vol. 68, no. 2, pp. 105–108, 1981. View at: Publisher Site | Google Scholar
  18. S. H. Noh, E. Y. Soh, C. S. Park, K. S. Lee, and K. B. Huh, “Evaluation of thyroid function after bilateral subtotal thyroidectomy for Graves' disease—a long term follow up of 100 patients,” Yonsei Medical Journal, vol. 35, no. 2, pp. 177–183, 1994. View at: Publisher Site | Google Scholar
  19. K. Sugino, T. Mimura, O. Ozaki et al., “Early recurrence of hyperthyroidism in patients with Graves' disease treated by subtotal thyroidectomy,” World Journal of Surgery, vol. 19, no. 4, pp. 648–652, 1995. View at: Publisher Site | Google Scholar
  20. B. Thjodleifsson, A. J. Hedley, D. Donald et al., “Outcome of sub-total thyroidectomy for thyrotoxicosis in Iceland and Northeast Scotland,” Clinical Endocrinology, vol. 7, no. 5, pp. 367–376, 1977. View at: Publisher Site | Google Scholar
  21. W. Michie, “Whither thyrotoxicosis?” British Journal of Surgery, vol. 62, no. 9, pp. 673–682, 1975. View at: Publisher Site | Google Scholar
  22. A. J. Hedley, P. D. Bewsher, S. J. Jones et al., “Late onset hypothyroidism after subtotal thyroidectomy for hyperthyroidism: implications for long term follow-up,” British Journal of Surgery, vol. 70, no. 12, pp. 740–743, 1983. View at: Publisher Site | Google Scholar

Copyright © 2015 Tae-Yon Sung et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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