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International Journal of Endocrinology
Volume 2017, Article ID 7938216, 9 pages
https://doi.org/10.1155/2017/7938216
Research Article

Metabolomic Signature of Coronary Artery Disease in Type 2 Diabetes Mellitus

1Herz- und Diabeteszentrum NRW, Ruhr-Universitaet Bochum, Diabeteszentrum, 32545 Bad Oeynhausen, Germany
2Research Unit of Molecular Epidemiology, Helmholtz Zentrum München, 85764 Neuherberg, Germany
3Institute of Epidemiology II, Helmholtz Zentrum München, 85764 Neuherberg, Germany
4Institute of Experimental Genetics, Genome Analysis Center, Helmholtz Zentrum München, 85764 Neuherberg, Germany
5Institute of Experimental Genetics, Life and Food Science Center Weihenstephan, Technische Universität München, 85354 Freising, Germany
6German Center for Diabetes Research (DZD), 85764 Neuherberg, Germany

Correspondence should be addressed to Bernd Stratmann; ed.wrn-zdh@nnamtartsb

Received 9 August 2016; Revised 1 December 2016; Accepted 20 December 2016; Published 1 March 2017

Academic Editor: Qian Li

Copyright © 2017 Bernd Stratmann et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Supplementary Material

Table S1 Mean values ± SD for metabolite concentrations (stratified for CAD cases (CAD) and controls (non-CAD)) and ORs ratios for all metabolites being significantly associated with CAD (p<0.05) using logistic regression analysis (with age and gender used as covariates). Table S2 ORs ratios for metabolites being significantly associated with CAD (p<0.05) using logistic regression analysis stratified for CAD class ~ metabolite + age + sex + BMI + HbA1c + Diabetes duration + triglycerides + LDL/HDL-ratio + Albumin + antihypertensive therapy + SBP + DBP + lipid lowering agents + eGFR. Table S3 Coefficients, Standard errors (SEs) and p-values for metabolites being significantly associated with CAD (p<0.05) using logistic regression analysis stratified for CAD class ~ metabolite + age + sex + BMI + HbA1c + Diabetes duration + triglycerides + LDL/HDL-ratio + Albumin + antihypertensive therapy + SBP + DBP + lipid lowering agents + eGFR.

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