Meta-Analysis of the Association between Vitamin D Receptor Polymorphisms and the Risk of Autoimmune Thyroid Disease

Table 4

The association between VDR rs2228570 polymorphism and AITD risk.

Comparison model	Subgroup	The number of studies	Sample size (cases/controls)	I^2		Effect model	OR (95% CI)
Homozygote comparison (TT versus CC)	AITD	14	1713/1474	64%	<0.001	Random	0.76 [0.55, 1.04]	0.09
	HT	7	509/440	27%	0.22	Fixed	0.77 [0.55, 1.07]	0.11
	GD	9	1204/1224	73%	<0.001	Random	0.79 [0.54, 1.15]	0.22
	European	6	819/907	72%	0.003	Random	0.93 [0.58, 1.49]	0.76
	Asian	8	894/567	45%	0.08	Random	0.63 [0.42, 0.93]	0.02
		11	1409/1301	71%	<0.001	Random	0.78 [0.53, 1.14]	0.20
		3	304/173	0%	0.89	Fixed	0.65 [0.42, 1.00]	0.05
Heterozygote comparison (CT versus CC)	AITD	14	2478/2123	72%	<0.001	Random	0.73 [0.56, 0.95]	0.02
	HT	7	665/600	77%	0.001	Random	0.61 [0.35, 1.06]	0.08
	GD	9	1813/1832	65%	0.004	Random	0.83 [0.64, 1.07]	0.14
	European	6	1145/1315	77%	<0.001	Random	0.78 [0.52, 1.16]	0.22
	Asian	8	1333/808	70%	0.001	Random	0.68 [0.47, 1.00]	0.05
		11	2008/1762	66%	0.001	Random	0.84 [0.64, 1.10]	0.21
		3	470/361	32%	0.23	Fixed	0.48 [0.36, 0.65]	<0.001
Dominant model (TT + CT versus CC)	AITD	14	3174/2836	76%	<0.001	Random	0.71 [0.54, 0.93]	<0.001
	HT	7	839/788	77%	<0.001	Random	0.60 [0.35, 1.02]	0.06
	GD	9	2335/2425	72%	<0.001	Random	0.81 [0.62, 1.06]	0.12
	European	6	1562/1795	80%	<0.001	Random	0.78 [0.52, 1.18]	0.24
	Asian	8	1612/1041	72%	<0.001	Random	0.65 [0.45, 0.95]	0.02
		11	2616/2416	74%	<0.001	Random	0.81 [0.60, 1.08]	0.14
		3	558/420	36%	0.21	Fixed	0.51 [0.38, 0.68]	<0.001
Recessive model (TT versus CT + CC)	AITD	14	3174/2836	54%	0.008	Random	0.87 [0.68, 1.10]	0.23
	HT	7	839/788	0%	0.46	Fixed	0.79 [0.59, 1.06]	0.11
	GD	9	2335/2425	64%	0.004	Random	0.90 [0.68, 1.19]	0.46
	European	6	1562/1795	60%	0.03	Random	1.05 [0.76, 1.45]	0.79
	Asian	8	1612/1041	23%	0.24	Fixed	0.72 [0.58, 0.91]	0.005
		11	2616/2416	64%	0.002	Random	0.83 [0.62, 1.11]	0.20
		3	558/420	0%	0.89	Fixed	1.02 [0.71, 1.48]	0.91
Allele comparison (T versus C)	AITD	15	3274/2936	75%	<0.001	Random	0.80 [0.68, 0.95]	0.01
	HT	7	839/788	72%	0.001	Random	0.69 [0.50, 0.97]	0.03
	GD	9	2335/2425	76%	<0.001	Random	0.87 [0.73, 1.05]	0.15
	European	6	1562/1795	79%	<0.001	Random	0.90 [0.70, 1.16]	0.41
	Asian	8	1612/1041	69%	0.002	Random	0.72 [0.56, 0.92]	0.008
	African	1	100/100	—	—	—	0.86 [0.53, 1.39]	0.54
		11	2716/2516	77%	<0.001	Random	0.83 [0.68, 1.01]	0.06
		3	558/420	38%	0.20	Fixed	0.72 [0.55, 0.93]	0.01

P_H: value of heterogeneity test; P_Z: value of Z test.