Meta-Analysis of the Association between Vitamin D Receptor Polymorphisms and the Risk of Autoimmune Thyroid Disease

Table 5

The association between VDR rs7975232 polymorphism and AITD risk.

Comparison model	Subgroup	The number of studies	Sample size (cases/controls)	I^2		Effect model	OR (95% CI)
Homozygote comparison (CC versus AA)	AITD	16	1899/1606	76%	<0.001	Random	1.16 [0.84, 1.61]	0.37
	HT	6	396/434	33%	0.19	Fixed	1.11 [0.80, 1.55]	0.52
	GD	12	1503/1403	81%	<0.001	Random	1.22 [0.81, 1.83]	0.34
	European	9	983/1016	71%	<0.001	Random	1.10 [0.76, 1.60]	0.62
	Asian	6	876/561	80%	<0.001	Random	1.02 [0.55, 1.92]	0.94
	African	1	40/29	—	—	—	5.84 [2.00, 17.02]	0.001
		12	1714/1439	76%	<0.001	Random	1.14 [0.81, 1.61]	0.45
		4	185/167	82%	0.001	Random	1.19 [0.39, 3.64]	0.75
Heterozygote comparison (CA versus AA)	AITD	16	2436/2287	61%	<0.001	Random	1.04 [0.83, 1.31]	0.71
	HT	6	504/538	30%	0.21	Fixed	1.11 [0.84, 1.47]	0.45
	GD	12	1932/1926	67%	<0.001	Random	1.03 [0.79, 1.36]	0.81
	European	9	1468/1585	43%	0.08	Random	1.02 [0.82, 1.27]	0.86
	Asian	6	904/654	71%	0.004	Random	0.91 [0.56, 1.47]	0.70
	African	1	64/48	—	—	—	3.02 [1.33, 6.87]	0.008
		12	2152/1976	66%	<0.001	Random	1.06 [0.83, 1.37]	0.63
		4	284/311	55%	0.09	Random	0.96 [0.53, 1.75]	0.90
Dominant model (CC + CA versus AA)	AITD	16	3544/3117	73%	<0.001	Random	1.08 [0.84, 1.38]	0.56
	HT	6	757/812	37%	0.16	Fixed	1.08 [0.83, 1.40]	0.56
	GD	12	2787/2681	78%	<0.001	Random	1.09 [0.80, 1.49]	0.57
	European	9	1884/2011	61%	0.009	Random	1.04 [0.81, 1.34]	0.73
	Asian	6	1570/1051	79%	<0.001	Random	0.94 [0.55, 1.60]	0.81
	African	1	90/55	—	—	—	3.62 [1.65, 7.93]	0.001
		12	3159/2727	75%	<0.001	Random	1.10 [0.84, 1.45]	0.50
		4	385/390	71%	0.02	Random	0.97 [0.48, 1.96]	0.94
Recessive model (CC versus CA + AA)	AITD	16	3544/3117	59%	0.001	Random	1.10 [0.90, 1.33]	0.36
	HT	6	757/812	18%	0.29	Fixed	0.97 [0.77, 1.21]	0.78
	GD	12	2787/2681	67%	<0.001	Random	1.13 [0.89, 1.42]	0.31
	European	9	1884/2011	58%	0.02	Random	1.06 [0.81, 1.40]	0.65
	Asian	6	1570/1051	62%	0.02	Random	1.06 [0.79, 1.42]	0.71
	African	1	90/55	—	—	—	2.79 [1.12, 6.95]	0.03
		12	3159/2727	52%	0.02	Random	1.06 [0.87, 1.28]	0.57
		4	385/390	77%	0.005	Random	1.25 [0.58, 2.68]	0.57
Allele comparison (C versus A)	AITD	16	3544/3117	75%	<0.001	Random	1.06 [0.91, 1.24]	0.44
	HT	6	757/812	33%	0.19	Fixed	1.01 [0.87, 1.17]	0.88
	GD	12	2787/2681	81%	<0.001	Random	1.09 [0.90, 1.32]	0.37
	European	9	1884/2011	70%	<0.001	Random	1.04 [0.86, 1.25]	0.69
	Asian	6	1570/1051	78%	<0.001	Random	1.00 [0.77, 1.31]	0.98
	African	1	90/55	—	—	—	2.29 [1.41, 3.73]	<0.001
		12	3159/2727	76%	<0.001	Random	1.06 [0.90, 1.25]	0.47
		4	385/390	79%	0.002	Random	1.04 [0.65, 1.66]	0.88

P_H: value of heterogeneity test; P_Z: value of Z test.