Verification That Mouse Chromosome 14 Is Responsible for Susceptibility to Streptozotocin in NSY Mice

Figure 4

STZ sensitivity at 12 weeks of age in R0 (; black circles), C3H (; white squares), R1 (; white circles), and R2 mice (; black triangles). Glucose concentrations and body weight are measured ad lib at days 0, 1, 2, 4, 5, 7, 8, and 14 days after STZ injection. Data are expressed as the mean ± SEM. (a) Blood glucose concentrations. The values of glucose in the R0 were reported as shown in Figure 3 legend. , compared with R1 (one-way ANOVA with post hoc test (Dunnett’s multiple comparison tests)). (b) The percentage of animals free of hyperglycemia. Mice with glycemia higher than 16.7 mmol/l were considered hyperglycemic. compared with R1 (log-rank test). (c) Body weight changes. The values of body weight in R0 were reported as shown in Figure 3 legend. compared with the basal body weight of R0 (Mann–Whitney U test).

(a)

(b)

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