The ANGPTL8 rs2278426 (C/T) Polymorphism Is Associated with Prediabetes and Type 2 Diabetes in a Han Chinese Population in Hebei Province
Table 1
Demographic and biochemical characteristics of participants in the healthy control, pre-DM, and T2DM patient groups.
Variables
Groups
All values
Pairwise comparisons
Controls (n = 524)
Pre-DM (n = 460)
T2DM (n = 460)
P1
P2
P3
Age (years)
46.02 ± 13.46
53.64 ± 11.94
59.10 ± 11.10
<0.001
<0.001
<0.001
<0.001
Male/female (n)
199/325
200/260
208/252
—
—
—
—
BMI (kg/m2)
25.32 ± 3.87
27.10 ± 3.98
27.04 ± 3.76
<0.001
<0.001
<0.001
1.000
SBP (mm/Hg)
122.80 ± 12.64
126.03 ± 12.01
130.92 ± 12.52
<0.001
<0.001
<0.001
<0.001
DBP (mm/Hg)
74.68 ± 9.09
76.41 ± 8.72
77.95 ± 8.57
<0.001
0.007
<0.001
0.025
TC (mmol/L)
4.62 ± 0.91
4.94 ± 0.95
5.01 ± 1.03
<0.001
<0.001
<0.001
0.803
TG (mmol/L)
1.27 ± 0.76
1.62 ± 1.06
1.88 ± 1.50
<0.001
<0.001
<0.001
0.001
HDL (mmol/L)
1.41 ± 0.31
1.30 ± 0.24
1.30 ± 0.31
<0.001
<0.001
<0.001
1.000
LDL (mmol/L)
2.85 ± 1.44
3.04 ± 0.77
2.90 ± 0.82
0.019
0.017
1.000
0.171
FPG (mmol/L)
5.00 ± 0.33
5.74 ± 0.58
7.86 ± 1.83
<0.001
<0.001
<0.001
<0.001
PBG (mmol/L)
5.54 ± 1.03
8.20 ± 1.31
12.52 ± 2.76
<0.001
<0.001
<0.001
<0.001
FINS (µU/mL)
9.66 ± 3.58
8.78 ± 3.11
7.82 ± 2.76
<0.001
<.001
<0.001
<0.001
Postprandial insulin (µU/m)
42.18 ± 21.44
63.85 ± 22.32
47.08 ± 15.89
<0.001
<0.001
0.001
<0.001
HbA1c (%)
5.52 ± 0.31
5.77 ± 0.40
7.34 ± 1.52
<0.001
<0.001
<0.001
<0.001
HOMA-IR
2.15 ± 0.83
2.24 ± 0.84
2.72 ± 1.13
<0.001
0.343
<0.001
<0.001
HOMA-B
136.00 ± 64.31
84.13 ± 39.40
42.93 ± 24.56
<0.001
<0.001
<0.001
<0.001
Values are shown as mean ± standard deviation. Each group was compared by one-way analysis of variance. values were corrected by a post hoc Bonferroni test. Pre-DM: prediabetes; T2DM: type 2 diabetes mellitus; BMI: body mass index; SBP: systolic blood pressure; DBP: diastolic blood pressure; TC: total cholesterol; TG: triglycerides; HDL: high-density lipoprotein; LDL: low-density lipoprotein; FPG: fasting plasma glucose; PBG: postprandial blood glucose; FINS: fasting insulin; HbA1c: glycosylated hemoglobin; HOMA-IR/B: homeostasis model assessment-insulin resistance/β-cell function. P1: pre-DM vs. controls; P2:T2DM vs. controls; P3:T2DM vs. pre-DM. Table 1 is reproduced from Hou et al. 2020 [48] (under the Creative Commons Attribution License).
