Ameliorative Effect of Rice Husk Methanol Extract on Liver and Kidney Toxicities Induced by Subchronic Codeine Administration

Table 1

Effect of rice husk extract on liver markers in codeine-administered male albino Wistar rats.

Parameter	NC	COD. only	RHE only	COD.+250 mg RHE	COD.+500 mg RHE	COD.+1,000 mg RHE
AST (U/l)	^a	^b	^ab	^ab	^ab	^ab
ALT (U/l)	^a	^a	^a	^a	^a	^a
ALP (U/l)	^abc	^c	^a	^bc	^abc	^ab
Total protein (g/dl)	^bc	^a	^d	^b	^bc	^cd
Albumin (g/dl)	^b	^a	^d	^b	^bc	^c
Total bilirubin (μmol/l)	^b	^d	^a	^c	2^b	^b
Conjugated bilirubin (μmol/l)	^b	^d	^a	^c	^b	^b

Groups with different superscripts are significantly different at , while groups with same superscripts are not. Key: NC = normal control; COD. only = administered 10 mg codeine/kg b.w of rat; RHE only = administered 500 mg of rice husk extract/kg b.w of rats; COD.+250 mg RHE = administered 10 mg codeine/kg b.w of rats +250 mg rice husk extract; COD.+500 mg RHE = administered 10 mg codeine/kg b.w of rats +500 mg rice husk extract; COD.+1,000 mg RHE = administered 10 mg codeine/kg b.w of rats +1000 mg rice husk extract.